Patents by Inventor Scott Kanner

Scott Kanner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR USING ENGINEERED DEUBIQUITINASES FOR PROBING UBIQUITIN-DEPENDENT CELLULAR PROCESSES
    Publication number: 20240067945
    Abstract: The present disclosure provides, inter alia, a recombinant engineered deubiquitinase (DUB) and methods for treating or ameliorating an inherited ion channelopathy, such as long QT syndrome, Brugada syndrome, or cystic fibrosis, in a subject. Further provided are methods for screening mutations causing such inherited ion channelopathies for a trafficking-deficient mutation that is treatable by the recombinant engineered DUB disclosed herein.
    Type: Application
    Filed: November 3, 2023
    Publication date: February 29, 2024
    Inventors: Henry M. Colecraft, Scott Kanner
  • COMPOSITIONS AND METHODS FOR USING ENGINEERED DEUBIQUITINASES FOR PROBING UBIQUITIN-DEPENDENT CELLULAR PROCESSES
    Publication number: 20240067946
    Abstract: The present disclosure provides, inter alia, a recombinant engineered deubiquitinase (DUB) and methods for treating or ameliorating an inherited ion channelopathy, such as long QT syndrome, Brugada syndrome, or cystic fibrosis, in a subject. Further provided are methods for screening mutations causing such inherited ion channelopathies for a trafficking-deficient mutation that is treatable by the recombinant engineered DUB disclosed herein.
    Type: Application
    Filed: November 3, 2023
    Publication date: February 29, 2024
    Inventors: Henry M. Colecraft, Scott Kanner
  • Compositions and methods for using engineered deubiquitinases for probing ubiquitin-dependent cellular processes
    Patent number: 11845967
    Abstract: The present disclosure provides, inter alia, a recombinant engineered deubiquitinase (DUB) and methods for treating or ameliorating an inherited ion channelopathy, such as long QT syndrome, Brugada syndrome, or cystic fibrosis, in a subject. Further provided are methods for screening mutations causing such inherited ion channelopathies for a trafficking-deficient mutation that is treatable by the recombinant engineered DUB disclosed herein.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: December 19, 2023
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Henry M. Colecraft, Scott Kanner
  • COMPOSITIONS AND METHODS FOR TARGETED PROTEIN STABILIZATION BY REDIRECTING ENDOGENOUS DEUBIQUITINASES
    Publication number: 20230235084
    Abstract: The present disclosure provides, inter alia, bivalent nanobody molecules and methods for treating or ameliorating the effects of a disease, such as long QT syndrome, or cystic fibrosis, in a subject, using the bivalent nanobody molecules disclosed herein. Also provided are methods of identifying and preparing nanobody binders that target proteins of interest.
    Type: Application
    Filed: July 13, 2022
    Publication date: July 27, 2023
    Inventors: Scott KANNER, Henry M. COLECRAFT
  • COMPOSITIONS AND METHODS FOR TARGETED PROTEIN STABILIZATION BY REDIRECTING ENDOGENOUS DEUBIQUITINASES
    Publication number: 20220370627
    Abstract: The present disclosure provides, inter alia, bivalent small molecules and methods for treating or ameliorating the effects of a disease, such as long QT syndrome, or cystic fibrosis, in a subject, using the bivalent small molecules disclosed herein. Also provided are methods of identifying and preparing small molecule binders that target proteins of interest.
    Type: Application
    Filed: July 13, 2022
    Publication date: November 24, 2022
    Inventors: Scott KANNER, Henry M. COLECRAFT
  • COMPOSITIONS AND METHODS FOR USING ENGINEERED DEUBIQUITINASES FOR PROBING UBIQUITIN-DEPENDENT CELLULAR PROCESSES
    Publication number: 20200263159
    Abstract: The present disclosure provides, inter alia, a recombinant engineered deubiquitinase (DUB) and methods for treating or ameliorating an inherited ion channelopathy, such as long QT syndrome, Brugada syndrome, or cystic fibrosis, in a subject. Further provided are methods for screening mutations causing such inherited ion channelopathies for a trafficking-deficient mutation that is treatable by the recombinant engineered DUB disclosed herein.
    Type: Application
    Filed: May 6, 2020
    Publication date: August 20, 2020
    Inventors: Henry M. Colecraft, Scott Kanner
  • Functional recovery of human lungs for transplantation
    Patent number: 9888680
    Abstract: The vasculature of a donor lung is perfused with a lung preserving fluid to preserve its structure. At the same time, a decellularization fluid is perfused through the airways, which strips away donor cells. The decellularized region is then seeded with pulmonary cells of the transplant recipient, which regenerate the lung. The pulmonary cells may be derived from stem cells, and the decellularization can be targeted to reduce the quantity of cells required.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: February 13, 2018
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Gordana Vunjak-Novakovic, Joshua Sonett, John O'Neill, Matthew Bacchetta, Donald O. Freytes, Gopal Singh, Scott A. Kanner
  • FUNCTIONAL RECOVERY OF HUMAN LUNGS FOR TRANSPLANTATION
    Publication number: 20140322696
    Abstract: The vasculature of a donor lung is perfused with a lung preserving fluid to preserve its structure. At the same time, a decellularization fluid is perfused through the airways, which strips away donor cells. The decellularized region is then seeded with pulmonary cells of the transplant recipient, which regenerate the lung. The pulmonary cells may be derived from stem cells, and the decellularization can be targeted to reduce the quantity of cells required.
    Type: Application
    Filed: April 4, 2014
    Publication date: October 30, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: GORDANA VUNJAK-NOVAKOVIC, JOSHUA SONETT, JOHN O'NEILL, MATTHEW BACCHETTA, DONALD O. FREYTES, GOPAL SINGH, SCOTT A. KANNER