Abstract: The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.

Abstract: An article of footwear includes an upper and a U-shaped foamed ankle collar. The ankle collar may form the topmost region of the foot receiving shoe opening and the foamed ankle collar may extend at least partially around and over a foot receiving shoe opening. The ankle collar is capable of being compressed by the user's heel during foot insertion and the ankle collar may exert pressure on the user's ankle once the foot is inserted. The ankle collar may have a flattened region along its length forming a downward angle from the topmost region toward the front of the article of footwear. The ankle collar may be located along at least a portion of an inner surface of a heel cup and the heel cup may have a shoe-horn like configuration. The ankle collar may reduce the dimensions of the shoe opening when not compressed.

Abstract: An article of footwear includes a heel cup that is attached to the upper and extends from the sole structure to at least a portion of the rear heel collar of the upper. The heel cup may be uniformly molded with an upper portion, midportion, and lower portion and the upper portion has a smaller mediolateral length than the midportion, and the midportion and lower portion form a concave structure that receives the heel. The upper portion has a first configuration and is capable of distorting into a second configuration under a load of a user's foot when the user is donning the footwear. In the second configuration, at least part of the upper portion is lowered and is capable of returning to the first configuration after the load of the user's foot is removed. The midportion includes a peripheral portion that may be thicker than a central portion.

Abstract: An article of footwear includes a heel counter support situated on the upper and above the sole structure. The heel counter support may have at least two hollow receptacles with backward angles, a compressible component having two ends, and each one of the two hollow receptacles receives one end of the compressible component. The compressible component may have a first configuration and may be capable of distorting into a second configuration under a load of a user's foot when the user is donning the footwear. The compressible component may be capable of automatically returning to the first configuration after the user's foot in fully inserted into the footwear.

Abstract: A gimbal handle assembly including: an inner gimbal and an outer gimbal that are concentrically linked and have pivot axes that are orthogonal relative to each other, a spool coupled to and rotatable around the outer gimbal, and a plurality of draw lines attached to the spool in a circumferential configuration, wherein rotation of the spool and/or rotation of the spool and the outer and inner gimbals increases or reduces tension in the draw lines. Also disclosed are a transcatheter valve delivery assembly that includes the gimbal handle assembly, a multi-lumen catheter, a sleeve attached to a distal end of the multi-lumen catheter, and a transcatheter heart valve including an expandable valve frame. Methods of delivering the transcatheter valve to a subject are described, wherein pitch and yaw orientations of the transcatheter valve can be precisely controlled with enhanced degrees of freedom.

Abstract: The technology generally relates to tailoring a back pressure regulator in a chromatographic system to reduce unswept volume within the back pressure regulator to achieve better sample detection and a reduction in chromatographic band distortion effects.

Abstract: The disclosure relates to pharmaceutical compositions and methods of using pharmaceutical compositions comprising effective dosages of an adenoviral-based biological delivery and expression system for use in the treatment or prevention of osteoarthritis in human or mammalian joints by long-term inducible gene expression of human or mammalian interleukin-1 receptor antagonist (IL-1Ra) in synovial cells, comprising a helper-dependent adenoviral vector containing a nucleic acid sequence encoding for human or mammalian interleukin-1 receptor antagonist (IL-1Ra), left and right inverted terminal repeats (L ITR and R ITR), the adenoviral packaging signal and non-viral, non-coding stuffer nucleic acid sequences, wherein the expression of the human or mammalian interleukin-1 receptor antagonist (IL-1Ra) gene within synovial cells is regulated by an inflammation-sensitive promoter.

Abstract: The present disclosure provides compositions comprising a thermosensitive hydrogel formulation of funapide and a tri-block polymer, and methods of use and manufacture of the compositions for management of acute pain or pain associated with surgical procedure.

Abstract: Disclosed herein are systems, methods, and apparatuses for implementing an online map-based sports fantasy game competition.

Abstract: Various examples are described for operating system update management. In some examples, an OS update schedule is generated. The OS update schedule specifies an OS update for a plurality of client devices. A command to deploy the OS update is transmitted to a subset of the client devices. Behavior data is received from the client devices that have applied the OS update. An update incompatibility identified using the behavior data. Instructions to fix the update incompatibility are transmitted to certain client devices.

Abstract: Various examples are described for operating system update management. In some examples, an OS update schedule is generated. The OS update schedule specifies an OS update for a plurality of client devices. A command to deploy the OS update is transmitted to a subset of the client devices. Update behavior data is received from the client devices that have applied the OS update. An analysis of the update behavior data correlates an update incompatibility with the OS update. The OS update is prevented from being deployed to additional client devices specified in the OS update schedule.

Abstract: A catheter that comprises a sheath that is connected at opposing ends to concentric tubes that move relative to each other in a manner that alternatively covers and exposes a medical device loaded onto the catheter. A portion of the sheath is arranged so as to invert upon itself so that axial movement of one tube relative to the other simultaneously moves the inversion point over or away from the device, alternatively covering or exposing the device.

Abstract: Disclosed herein are systems, methods, and apparatuses for implementing an online map-based sports fantasy game competition.

Abstract: Described is an interface module for robotic loading and unloading of a liquid chromatography sample manager. The module includes a transfer drawer receiving apparatus having a device track and a drawer drive system configured to transport a transfer drawer along the device track into and out from a sample tray of a sample manager. The transfer drawer receives a sample-vial carrier that holds samples to be analyzed. The module further includes a window apparatus that has a window controllable to be in an open state or a closed state. When in the open state, transport of the transfer drawer through the window into or out from the sample manager permits loading of the sample-vial carrier into the sample tray and unloading of the sample-vial carrier from the sample tray. In the closed state, the window apparatus substantially seals the internal environment of the sample manager from the ambient environment.

Abstract: A needle for aspirating a sample from a sample source and injecting the sample into a liquid chromatography system, the needle including a needle body having a rough textured surface finish for at least a portion of the needle body, wherein the rough textured surface finish reduces a coefficient of friction of the needle body, is provided. Furthermore, an associated method is also provided.

Abstract: The technology generally relates to tailoring a back pressure regulator in a chromatographic system to reduce unswept volume within the back pressure regulator to achieve better sample detection and a reduction in chromatographic band distortion effects.

Abstract: A gimbal handle assembly including: an inner gimbal and an outer gimbal that are concentrically linked and have pivot axes that are orthogonal relative to each other, a spool coupled to and rotatable around the outer gimbal, and a plurality of draw lines attached to the spool in a circumferential configuration, wherein rotation of the spool and/or rotation of the spool and the outer and inner gimbals increases or reduces tension in the draw lines. Also disclosed are a transcatheter valve delivery assembly that includes the gimbal handle assembly, a multi-lumen catheter, a sleeve attached to a distal end of the multi-lumen catheter, and a transcatheter heart valve including an expandable valve frame. Methods of delivering the transcatheter valve to a subject are described, wherein pitch and yaw orientations of the transcatheter valve can be precisely controlled with enhanced degrees of freedom.

Abstract: Devices and methods for use in a hip replacement surgical procedure. One aspect includes methods and devices for reaming selective regions of the femoral canal. This may include reaming distal and proximal sections of the femoral canal prior to reaming a middle region of the canal. Another aspect includes a dummy implant and methods of use. The dummy implant is inserted into the femoral canal and may be used for one or more of retraction of the femur, gauging a space with the acetabulum, and further revising the femoral cut. The aspects may be used together in a single surgical procedure or separately in different surgical procedures.

Abstract: Various examples are described for operating system update management. In some examples, an OS update schedule is generated. The OS update schedule specifies an OS update for a plurality of client devices. A command to deploy the OS update is transmitted to a subset of the client devices. Update behavior data is received from the client devices that have applied the OS update. An analysis of the update behavior data correlates an update incompatibility with the OS update. The OS update is prevented from being deployed to additional client devices specified in the OS update schedule.