Abstract: The disclosure provides materials and methods for assessing the presence and level of polyanionic compounds in a sample that inhibit PCR reactions, including assays for the presence, and optionally the amount, of polyvinyl sulfonate, as well as materials and methods for the reduction or removal of such compounds from buffer solutions and from protein solutions using a variety of approaches, including titration-based techniques.

Abstract: The present disclosure describes a wireless microphone system that allows one or more microphones to wirelessly communicate with one or more wireless receivers. The wireless microphone system may allow for a plurality of microphones to be used interchangeably with the one or more receivers. The communications between the one or more wireless microphones and the one or more wireless receivers may utilize more than one wireless communication protocol, such as Bluetooth Low Energy (BLE) as well as a proprietary protocol such as a non-Bluetooth 2.4 GHz wireless communication protocol, and the system may switch between the wireless communication protocols. The one or more wireless microphones may further synchronize communications with the one or more receivers.

Abstract: The present disclosure describes a wireless microphone system that allows one or more microphones to wirelessly communicate with a receiver. Additionally, the wireless microphone system may allow for a plurality of microphones to be used interchangeably with the receiver. To ensure communication between the receiver and the one or more microphones, the receiver may occasionally transmit a synchronization signal to the one or more microphones. In response to receiving the synchronization signal, at least one of the one or more microphones may determine that a clock of the at least one microphone is drifting from the master audio clock of the receiver. The at least one microphone may then adjust the microphone's audio clock to re-synchronize the audio clock of the microphone with the master audio clock of the receiver.

Abstract: The present disclosure relates to aflibercept, in particular, attributes of aflibercept. Also provided herein are methods of characterizing and modifying the attributes of aflibercept and compositions comprising aflibercept with particular attributes.

Abstract: The present disclosure provides a method of controlling the Antibody Dependent Cellular Cytotoxicity (ADCC) activity of a glycosylated and afucosylated IgG1 antibody composition. In exemplary embodiments, the method includes (1) determining the ADCC activity of a glycosylated and afucosylated IgG1 antibody composition; and (2) increasing or decreasing the ADCC activity of the IgG1 antibody composition by increasing or decreasing the amount of terminal ?-galactose in the afucosylated glycan species at the consensus glycosylation site. Related methods of matching ADCC activity of a reference glycosylated and afucosylated IgG1 antibody composition and methods of engineering a specific target ADCC activity of a glycosylated and afucosylated IgG1 antibody composition are further provided herein.

Abstract: Provided herein are methods of modulating Antibody Dependent Cellular Phagocytosis (ADCP) activity of an antibody composition. In exemplary embodiments, the method comprises modulating the amount of (a) galactosylated glycans of the antibody, (b) afucosylated glycans of the antibody, (c) high mannose glycans of the antibody, or (d) a combination thereof, to modulate ADCP activity of the antibody, as further described herein.

Abstract: The present disclosure provides stable, solid protein formulations. The present disclosure also provides methods of using these formulations in protein detection kits that are stable over a variety of temperatures for extended time periods.

Abstract: An apparatus and method for determining the concentration of a medically significant component of a biological fluid comprise providing a cell supporting a chemistry which reacts with the medically significant component. Placement of first and second terminals of the cell in contact with first and second terminals, respectively, of an instrument permits the instrument to assess the reaction. The instrument determines a first response of the cell to a first signal, and determines based upon the first response whether to proceed with the determination of the concentration of the medically significant component of the biological fluid. If the determination is to proceed, the instrument determines the type of sample that has been applied.