Patents by Inventor Scott L. Weinrich
Scott L. Weinrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7585966Abstract: This invention provides inhibitory polynucleotides, such as antisense molecules, directed against accessible regions in the telomerase ribonucleoprotein. The polynucleotides are useful for inhibiting the activity of telomerase in cells and for treating cancer.Type: GrantFiled: November 8, 1999Date of Patent: September 8, 2009Assignee: Geron CorporationInventors: James T. Kealey, Ronald Pruzan, Scott L. Weinrich
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Patent number: 7067283Abstract: This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, intermediate-selectivity matrices, methods that separate molecules based on their size, shape, or buoyant density, and by affinity purification.Type: GrantFiled: March 26, 2004Date of Patent: June 27, 2006Assignee: Geron CorporationInventors: Scott L. Weinrich, Edward M. Atkinson, III, Serge P. Lichtsteiner, Alain P. Vasserot, Ronald A. Pruzan
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Patent number: 6787133Abstract: This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, intermediate-selectivity matrices, methods that separate molecules based on their size, shape, or buoyant density, and by affinity purification.Type: GrantFiled: December 24, 2002Date of Patent: September 7, 2004Assignee: Geron CorporationInventors: Scott L. Weinrich, Edward M. Atkinson, III, Serge P. Lichtsteiner, Alain P. Vasserot, Ronald A. Pruzan
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Publication number: 20030190638Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.Type: ApplicationFiled: August 29, 2002Publication date: October 9, 2003Applicant: Board of Regents, The University of Texas SystemInventors: Michael D. West, Calvin B. Harley, Scott L. Weinrich, Catherine M. Strahl, Michael J. McEachern, Jerry Shay, Woodring E. Wright, Elizabeth H. Blackburn, Nam Woo Kim, Homayoun Vaziri
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Publication number: 20030186282Abstract: This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, intermediate-selectivity matrices, methods that separate molecules based on their size, shape, or buoyant density, and by affinity purification.Type: ApplicationFiled: December 24, 2002Publication date: October 2, 2003Inventors: Scott L. Weinrich, Edward M. Atkinson, Serge P. Lichtsteiner, Alain P. Vasserot, Ronald A. Pruzan
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Patent number: 6551774Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.Type: GrantFiled: August 20, 1999Date of Patent: April 22, 2003Assignees: Board of Regents, The University of Texas System, The Regents of the University of California, Geron CorporationInventors: Michael D. West, Calvin B. Harley, Scott L. Weinrich, Catherine M. Strahl, Michael J. McEachern, Jerry Shay, Woodring E. Wright, Elizabeth H. Blackburn, Nam Woo Kim, Homayoun Vaziri
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Patent number: 6545133Abstract: This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, intermediate-selectivity matrices, methods that separate molecules based on their size, shape, or buoyant density, and by affinity purification.Type: GrantFiled: November 20, 2000Date of Patent: April 8, 2003Assignee: Geron CorporationInventors: Scott L. Weinrich, Edward M. Atkinson, III, Serge P. Lichtsteiner, Alain P. Vasserot, Ronald A. Pruzan
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Patent number: 6517834Abstract: This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, intermediate-selectivity matrices, methods that separate molecules based on their size, shape, or buoyant density, and by affinity purification.Type: GrantFiled: November 20, 2000Date of Patent: February 11, 2003Assignee: Geron CorporationInventors: Scott L. Weinrich, Edward M. Atkinson, III, Serge P. Lichtsteiner, Alain P. Vasserot, Ronald A. Pruzan
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Patent number: 6391554Abstract: Methods and kits are provided for diagnosis of specific cancerous conditions. The invention features a method for diagnosis of a condition in a patient associated with an elevated level of telomerase activity within a cell. The method involves determining the presence or amount of telomerase within the cells in the patient, e.g. by the use of the polymerase chain reaction. In one embodiment of the invention, the condition associated with elevated telomerase activity is chosen from prostate cancer, breast cancer, colon cancer, renal cancer, ovarian/cervical cancer, lung cancer, and leukemia. The invention allows cancer to be detected even in tissues and cells which are not positive by pathology.Type: GrantFiled: November 23, 1999Date of Patent: May 21, 2002Assignees: Geron Corporation and Board of Regents, The University of Texas SystemsInventors: Michael D. West, Jerry W. Shay, Woodring E. Wright, Nam Woo Kim, Calvin B. Harley, Scott L. Weinrich
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Patent number: 6261556Abstract: This invention provides purified human telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of a first matrix that binds molecules bearing negative charges, a matrix that binds molecules bearing positive charges, a second matrix that binds molecules bearing negative charges, an affinity purification step and a matrix that separates molecules according to their size.Type: GrantFiled: October 18, 1999Date of Patent: July 17, 2001Assignee: Geron CorporationInventors: Scott L. Weinrich, Edward M. Atkinson, III, Serge P. Lichtsteiner, Alain P. Vasserot, Ronald A. Pruzan, James T. Kealey
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Patent number: 6007989Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.Type: GrantFiled: March 14, 1997Date of Patent: December 28, 1999Assignees: Board of Regents, The University of Texas System, The Regents of the University of California, Geron CorporationInventors: Michael D. West, Calvin B. Harley, Scott L. Weinrich, Catherine M. Strahl, Michael J. McEachern, Jerry Shay, Woodring E. Wright, Elizabeth H. Blackburn, Nam Woo Kim, Homayoun Vaziri
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Patent number: 5989807Abstract: Methods and kits are provided for diagnosis of specific cancerous conditions. The invention features a method for diagnosis of a condition in a patient associated with an elevated level of telomerase activity within a cell. The method involves determining the presence or amount of telomerase within the cells in the patient, e.g. by the use of the polymerase chain reaction. In one embodiment of the invention, the condition associated with elevated telomerase activity is chosen from prostate cancer, breast cancer, colon cancer, renal cancer, ovarian/cervical cancer, lung cancer, and leukemia. The invention allows cancer to be detected even in tissues and cells which are not positive by pathology.Type: GrantFiled: June 7, 1994Date of Patent: November 23, 1999Assignees: Geron Corporation & Board of Regents, The University of Texas SystemInventors: Michael D. West, Jerry Shay, Woodring E. Wright, Nam Woo Kim, Calvin B. Harley, Scott L. Weinrich
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Patent number: 5968506Abstract: This invention provides purified human telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of a first matrix that binds molecules bearing negative charges, a matrix that binds molecules bearing positive charges, a second matrix that binds molecules bearing negative charges, an affinity purification step and a matrix that separates molecules according to their size.Type: GrantFiled: April 4, 1997Date of Patent: October 19, 1999Assignee: Geron CorporationInventors: Scott L. Weinrich, Edward M. Atkinson, III, Serge P. Lichtsteiner, Alain P. Vasserot, Ronald A. Pruzan, James T. Kealey
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Patent number: 5846723Abstract: Methods of detecting the RNA component of telomerase, diagnosing cancer, and determining its prognosis using polynucleotides that hybridize to the RNA component of mammalian telomerase in a sample.Type: GrantFiled: December 20, 1996Date of Patent: December 8, 1998Assignee: Geron CorporationInventors: Nam Woo Kim, Fred Wu, James T. Kealey, Ronald Pruzan, Scott L. Weinrich
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Patent number: 5629154Abstract: Telomerase activity in a sample can be measured using a two reaction protocol involving telomerase substrate and primer extension steps.Type: GrantFiled: September 28, 1994Date of Patent: May 13, 1997Assignee: Geron CorporationInventors: Nam W. Kim, Calvin B. Harley, Scott L. Weinrich