Abstract: Provided are 6-membered heteroaryl-containing aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.

Abstract: Provided are 5-membered heteroaryl-containing aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.

Abstract: A device for weight management includes a platform, a weight sensor configured to measure a weight of a user when the user is positioned on the platform, an input mechanism configured to receive input related to target weight of the user, a converter configured to convert the measured weight to a non-numerical output based upon the input, and a display configured to provide the non-numerical output to the user without providing the measured weight to the user.

Abstract: Apparatus, systems, methods, and related computer program products for managing demand-response programs and events. The systems disclosed include an energy management system in operation with an intelligent, network-connected thermostat located at a structure. The thermostat controls an HVAC system to cool the structure using a demand response event implementation profile over the demand response event period. The thermostat can also receive a requested change to the setpoint temperatures defined by the demand response event implementation profile and access a determination of an impact on energy shifting that would result if the requested change is incorporated into the demand response event implementation profile. This determination can be communicated to the energy consumer.

Abstract: The present invention is directed in part to soybean variety CW1660196, EE1803165, EE1762224, EE1762072, and/or EE1861244 breeding and development. The present invention particularly relates to soybean variety EE1803165, EE1762224, EE1762072, and/or EE1861244 and its seed, cells, germplasm, plant parts, and progeny, and methods of using EE1803165, EE1762224, EE1762072, and/or EE1861244, e.g., in a breeding program.

Abstract: This document relates to materials and methods for modulating ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.

Abstract: A system for implanting a flow modifying device in a heart comprises a flow modifying device comprising a tubular body comprising first and second openings located at first and second ends of the tubular body and a neck positioned between the first opening and the second opening, and a guide catheter comprising a flexible elongate shaft comprising a proximal portion comprising a fitting for receiving an insertion instrument and distal portion comprising an enlarged distal tip to prevent the flexible elongate shaft from passing through the flow modifying device. A guide catheter for cannulating a coronary sinus from a superior vena cava comprises a pre-formed distal portion comprising a proximal straight zone, a proximal curved zone extending along a first curved path, a distal straight zone extending along a straight path and a distal curved zone extending along a second curved path. The guide catheter can have different stiffnesses.

Abstract: A faulty meter socket detection system configured to detect faulty sockets as evidenced by series arcs in an input current waveform or an increased temperature of the meter is disclosed. The system includes a metering circuit configured to receive an input current waveform, and a controller including a power monitoring module. The meter may also include a temperature sensor. The power monitoring module is configured detect series arc currents input current waveform data by filtering the input current waveform data to produce filtered data, performing feature recognition on the filtered data, classifying the features of the filtered data, performing temporal processing on the filtered data, (optionally) scaling the temporal processing of the filtered data, and, scoring the input current waveform based on the temporal processing of the filtered data. The temperature sensor may detect an increased temperature of the meter, which may indicate a faulty socket.

Abstract: Systems and methods disclosed include identifying a topic and a perspective of an input text to be sent to a receiver, determining a receiver perspective based on the topic of the input text and a receiver persona associated with the receiver, determining, by comparing the perspective of the input text and the perspective of the receiver, whether the input text includes a language having an offensive probability beyond an offensive probability threshold, after determining that the input text includes the language having the offensive probability beyond the offensive probability threshold, providing an option to modify the input text on a user interface of the sender, and modifying the input text to have the offensive probability below the offensive probability threshold when the option is selected.

Abstract: The invention relates to a kit for refilling an implantable pump and, more particularly, to packaging and contents of a kit to improve the workflow of a user while adding medication to an implantable pump that has been surgically implanted in a patient. kit for refilling an implanted pump. The kit comprises a setup tray containing at least one needle, a fenestrated drape, a first syringe, a needle, a filter, and clampable tubing; and a medication tray containing a second syringe, at least one ampule of medication, an ampule opener, and aspiration tubing. The medication tray is molded to have a recess that securely holds the at least one ampule in both a horizontal position and in a vertical position.

Abstract: Vibration isolation can be provided for a vibration sensitive component to be bonded to electronic circuit boards or other surfaces by an assembly that includes two substrates with rigid portions that are electrically coupled to each other via a flexible interconnect. The rigid portions of the two substrates are bonded together via an elastic structure in a stacked arrangement with the first substrate above the second substrate. The flexible interconnect electrically couples the first substrate to the second substrate and the second substrate is configured to be bonded and electrically coupled to an electronic circuit board or other larger substrate via contacts on a surface of the rigid portion of the second substrate. The vibration sensitive component can be bonded to the rigid portion of the first substrate and couped to the flexible interconnect via the first substrate, thereby coupling it to the second substrate and the larger substrate.

Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

Abstract: Blood pump assemblies and methods of manufacturing and operating blood pump assemblies are provided. The blood pump assembly includes a pump and an impeller blade rotatably coupled to the pump. The blood pump assembly also includes a pump housing component sized for passage through a body lumen and coupled to the pump. The pump housing component includes a peripheral wall extending about a rotation axis of the impeller blade. The peripheral wall includes an inner peripheral wall surface and an outer peripheral wall surface. The peripheral wall also includes one or more blood exhaust apertures. Each blood exhaust aperture in the one or more blood exhaust apertures is defined by an inner aperture edge and an outer aperture edge. Each inner aperture edge is chamfered between the inner peripheral wall surface and the outer peripheral wall surface.

Abstract: Methods, systems, and devices for wireless communications are described. A user equipment (UE) may receive, from a network entity, one or more control signals indicating information associated with a set of occasions for a transmission time interval (TTI) corresponding to a low power operation mode of the UE. For example, the set of occasions may include one or more of a wake up signal (WUS) monitoring occasion, a synchronization signal block (SSB) occasion, a channel state information (CSI) reporting occasion, and a discontinuous reception (DRX) on duration occasion. The UE may determine whether to skip the WUS monitoring occasion based on a respective duration and a respective start time for each occasion of the set of occasions associated with the information indicated by the one or more control signals.

Abstract: Implants and instruments for providing an ideal trajectory for the insertion of instruments and screws during implantation of an interbody implant in a spinal surgery are disclosed.

Abstract: Vertical semiconductor devices with deep wells and associated fabrication methods are disclosed herein. A disclosed process for forming a semiconductor device includes forming, on a drift region having a first conductivity type, a deep well region for the semiconductor device. The deep well region can be formed by an implant. The deep well region has a second conductivity type. The deep well region of the second conductivity type leaves a portion of the surface of the drift region exposed. The process also includes epitaxially forming a semiconductor region that extends from the surface of the drift region to above the deep well region for the semiconductor device. The semiconductor region can be used as at least a part of the main operational current path of the semiconductor device when the semiconductor device is finished and is devoid of implant damage from the implant.

Abstract: According to one embodiment, a method, computer system, and computer program product for tracking positions and characteristics of one or more individuals in proximity to a user to dynamically assess a threat of physiological harm to the user is provided. The present invention may include identifying, by one or more sensors integrated into one or more wearable devices on the person of a user, one or more individuals in proximity to the user; generating a dynamic threshold corresponding to each of the one or more individuals; responsive to identifying one or more characteristics of the individual, updating the dynamic threshold; and responsive to a distance between an individual of the one or more individuals and the user falling below the dynamic threshold associated with the individual, transmitting an alert to the user.

Abstract: This disclosure relates to deep trench capacitors embedded in a package substrate on which an integrated circuit is mounted. In some aspects, a chip package includes an integrated circuit die that has a power distribution circuit for one or more circuits of the integrated circuit. The chip package also includes a substrate different from the integrated circuit and having a first surface on which the integrated circuit die is mounted and a second surface opposite the first surface. The substrate includes one or more cavities formed in at least one of the first surface or the second surface. The chip package also includes one or more deep trench capacitors disposed in at least one of the one or more cavities. Each deep trench capacitor is connected to the power distribution circuit by conductors.