Abstract: Described herein are methods of treating various neurological disorders using electrical nerve conduction block (ENCB) without causing electrochemical damage. Examples of the various neurological disorders can include pain, muscle spasticity, hyperhidrosis, vertigo, sialorrhea, or the like. The methods can include placing an electrode contact in electrical communication with a nerve that transmits a signal related to the neurological disorder. The method also includes applying an ENCB to the nerve through the electrode contact. The electrode contact can include a high charge capacity material that prevents formation of damaging electrochemical reaction products at a charge delivered by the ENCB. The method also includes blocking transmission of the signal related to the neurological disorder through the nerve with the ENCB to treat the neurological disorder.

Abstract: One aspect of the present disclosure relates a method for determining effective stimulation parameters to apply to a patient in order to improve the patient's medical condition. The method can employ functional and/or structural imaging to determine the effective stimulation parameters. As such, the method includes programming a stimulation device with an initial stimulation parameter. An image can be received of at least a portion of the patient that is affected by a stimulation by the stimulation device. Based on the image, the efficacy of the stimulation with the at least one initial stimulation parameter can be assessed. The at least one initial stimulation parameter can be updated based on the assessed efficacy.

Abstract: One aspect of the present disclosure relates to lead assemblies for stimulating tissue. The lead assemblies can include lead bodies that are slid ably coupled to each other and include one or more contacts that are movably disposed within the slits of the lead bodies. The positions of the one or more contacts can be adjusted to change the direction of stimulation. For example, the positions of the one or more contacts can be adjusted based on theoretically-optimal positions determined from a patient-specific computer model. Parameters of the stimulation applied by the one or more contacts can also be optimized based on the patient-specific computer model.