Patents by Inventor Scott Lesley

Scott Lesley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced methods for crystallographic structure determination employing hydrogen exchange analysis
    Patent number: 7363171
    Abstract: The present invention provides methods for crystallographic structure determination employing hydrogen exchange analysis. Hydrogen exchange analysis is used to identify unstructured regions of a protein, and then hydrogen exchange analysis repeated after the protein is admixed with candidate agents and/or conditions that may induce structure in said identified unstructured regions. Agents that induce desired structure in the protein are then employed, admixed with the protein, in co-crystallization studies for structure determination. Hydrogen exchange analysis is performed by determining the quantity of isotope and/or rate of exchange of peptide amide hydrogen(s) with isotope on a labeled protein. Proteins with agent-induced decreases in unstructured regions, and thus improved hydrogen exchange structural maps, are optimal for high quality crystallization and structure determination.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: April 22, 2008
    Assignee: The Regents of the University of California
    Inventors: Virgil L. Woods, Jr., Scott Lesley
  • Enhanced methods for crystallographic structure determination employing hydrogen exchange analysis
    Publication number: 20060166273
    Abstract: The present invention provides methods for crystallographic structure determination employing hydrogen exchange analysis. Hydrogen exchange analysis is used to identify unstructured regions of a protein, and then hydrogen exchange analysis repeated after the protein is admixed with candidate agents and/or conditions that may induce structure in said identified unstructured regions. Agents that induce desired structure in the protein are then employed, admixed with the protein, in co-crystallization studies for structure determination. Hydrogen exchange analysis is performed by determining the quantity of isotope and/or rate of exchange of peptide amide hydrogen(s) with isotope on a labeled protein. Proteins with agent-induced decreases in unstructured regions, and thus improved hydrogen exchange structural maps, are optimal for high quality crystallization and structure determination.
    Type: Application
    Filed: November 24, 2004
    Publication date: July 27, 2006
    Inventors: Virgil Woods, Scott Lesley