Abstract: The present application provides novel heterocyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful for inhibiting ERK1/2. By administering to a patient in need a therapeutically effective amount of one or more of the compounds of formula (I), wherein X, Y, Z, J, M, and R1 to R8 are defined herein, these compounds are effective in treating conditions associated with dysregulation of the RAS/RAF/MEK/ERK pathway. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer.

Abstract: A portable cooler and tackle box provided in sizes from about 5 gallon to about 60 gallon capacity with at least one wheel affixed on or proximally to the bottom and at least one handle affixed exteriorly, and insulation, and a pivotally attached cover. Aprons are removably attached to the exterior and are fitted with pockets, holders, and pouches for holding accessories, and at least one horizontal partition wall is within the main body. At least one tray is slideably contained within the lower interior. The main body interior may contain at least one permanent or removable compartment.

Abstract: A pressure regulator that regulates the pressure at which carbon dioxide is introduced to water in a carbonated beverage system based on the temperature of the water. The regulator may be capable of operating in a first mode in which the carbon dioxide pressure varies substantially linearly over a first water temperature range, and a second mode in which the carbon dioxide pressure is substantially constant over a second water temperature range. A first flow path having a relatively small gas flow capacity may serve as a pilot to control the gas flow through a second flow path having a larger gas flow capacity.

Abstract: The present invention can generally relate to a pin for a dispenser comprising a rounded end formed integrally with a shaft terminating in a point and a bulbous protrusion is positioned between the rounded end and the point.

Abstract: The present invention relates to a dispenser for a plurality of articles, such as lids, for preferably dispensing the endmost article from a stack of articles.

Abstract: A dispenser for a lid from a plurality of nested lids can include at least one member for isolating at least one adjacent to an endmost lid whereby the endmost lid can separate from the adjacent lid and be dispensed.

Abstract: A dispenser for a lid from a plurality of nested lids can include at least one member for isolating at least one adjacent to an endmost lid whereby the endmost lid can separate from the adjacent lid and be dispensed.

Abstract: A dispenser for a lid from a plurality of nested lids can include at least one member for isolating at least one lid adjacent to an endmost lid whereby the endmost lid can separate from the adjacent lid and be dispensed.

Abstract: A method and apparatus as presented for monitoring the condition of oil in a transmission to present a service indicia prior to the time that the oil life has been spent. A thermosensor and a tachometer are associated with the transmission to present respective output signals correlated with operating temperature and transmission revolutions. The revolutions of the transmission are weighted as a function of the deviation of the temperature from a temperature standard. The resulting effective revolutions are then applied to a down counter which is initially loaded to the number of allowable effective revolutions when the transmission oil is changed or the transmission serviced. When the down counter has counted out, a message is displayed indicating the need for service.