Abstract: The present invention provides a method of treating depression disease in a treatment resistant patient comprising administering to a mucosal membrane of a patient an effective amount of a pharmaceutically acceptable composition comprising an effective amount of ketamine or dextromethorphan, wherein the mucosal administration of the ketamine or dextromethorphan containing composition allows for the mucosal absorption of the composition eliminating the digestive tract of the patient for effecting a rapid acting antidepressant treatment of the treatment resistant patient. This method includes administering the composition to a patient's mucosal membrane of a respiratory tract, a genitourinary tract, an oral tract, or rectal tract of the patient. A pharmaceutically acceptable composition comprising ketamine or dextromethorphan and a vehicle is disclosed. A biomarker for identifying a depressive disease is set forth.

Abstract: An execution environment accommodating object-based software transparently monitors interactions with software objects to generate operational management information for managing programs executing at plural computers. Notifications are directed to a software manager in the form of events, which can additionally be provided to applications or user programs. The software manager can group the events into sets and derive various operational management metrics from them to provide an overall picture of a program's performance, including availability. A hierarchical arrangement feature facilitates gathering information for programs scattered over plural computers. An alert feature provides warnings if metrics fall outside a specified threshold. In addition, the alert feature can automatically subscribe to additional sets of events to dynamically select the information collected by the software manager.

Abstract: An execution environment accommodating object-based software transparently monitors interactions with software objects to generate operational management information for managing programs executing at plural computers. Notifications are directed to a software manager in the form of events, which can additionally be provided to applications or user programs. The software manager can group the events into sets and derive various operational management metrics from them to provide an overall picture of a program's performance, including availability. A hierarchical arrangement feature facilitates gathering information for programs scattered over plural computers. An alert feature provides warnings if metrics fall outside a specified threshold. In addition, the alert feature can automatically subscribe to additional sets of events to dynamically select the information collected by the software manager.

Abstract: An execution environment accommodating object-based software transparently monitors interactions with software objects to generate operational management information for managing programs executing at plural computers. Notifications are directed to a software manager in the form of events, which can additionally be provided to applications or user programs. The software manager can group the events into sets and derive various operational management metrics from them to provide an overall picture of a program's performance, including availability. A hierarchical arrangement feature facilitates gathering information for programs scattered over plural computers. An alert feature provides warnings if metrics fall outside a specified threshold. In addition, the alert feature can automatically subscribe to additional sets of events to dynamically select the information collected by the software manager.

Abstract: Disclosed are methods and systems for constructing a model of transactional object middleware components. The system collects and derives metrics based on events generated by the middleware during operation. Event data are correlated with business model information to provide a real-time, business-based view of transaction throughput in e-commerce and other business-related computing systems.