Abstract: Disclosed herein is a package substrate and a method for fabricating the same. In one example, a package substrate includes a core having an outer edge and a first plurality of first interconnect layers disposed on the core. The first plurality of interconnect layers disposed on the core include an outermost dielectric layer disposed farthest from the core. The outermost dielectric layer has an edge that is recessed from the edge of the core.

Abstract: The present disclosure provides ketoreductase enzymes having improved enzymatic properties including the capability of reducing hydroxy indanones to provide diastereomerically pure 1,3-indane diols useful for the synthesis of belzutifan. Also provided are polynucleotides encoding the ketoreductase enzymes, and host cells capable of expressing the ketoreductase enzymes. A purification procedure for isolating the ketoreductase enzymes is also provided.

Abstract: In one example, a method includes providing a first side of a semiconductor substrate with a plurality of transistors, etching a second side of the substrate, opposite the first side, with a pattern of trenches, the trenches having a pre-defined depth and width, and providing the etched semiconductor substrate in a package. In one example, the predefined depth and width of the trenches is such so as to increase the surface area of the second side of the substrate by at least 20 percent. In one example, the method also includes providing a layer of a thermal interface material (TIM) on the second side of the substrate, including to fill at least a portion of the trenches.

Abstract: A multi-use ax may comprise a head and a handle, each comprising multiple functionalities. In various embodiments, the head and the handle may comprise functionalities such as an anchor and attachment point, or belay loop, to allow a user to bail out of a hazardous environment. In various embodiments the head and/or the handle may comprise functionalities to provide a means by which a user may shut off gas and/or water at various sources.

Abstract: Techniques for providing a multi-use hatchet are described herein. In some examples, the multi-use hatchet may comprise a head and a handle, each comprising multiple uses or functionalities. In some examples, the head may include an anchor point and an attachment point or hole to allow a user to bail out of a hazardous environment. In various examples, the handle may comprise one or more holes to serve as a belaying device, and a sharpened distal end for plying or other functions.

Abstract: A multi-use ax may comprise a head and a handle, each comprising multiple functionalities. In various embodiments, the head and the handle may comprise functionalities such as an anchor and attachment point, or belay loop, to allow a user to bail out of a hazardous environment. In various embodiments the head and/or the handle may comprise functionalities to provide a means by which a user may shut off gas and/or water at various sources.