Abstract: A bone screw extension assembly for use in placing a connecting rod percutaneously into tissue of a patient comprises a multi-axial bone screw and a screw extension releasably coupled to yoke of the bone screw. The screw extension includes coaxially disposed outer sleeve and inner sleeves that are rotatable relative to each other. A screw engaging member projects radially from the distal end the inner sleeve and is configured to engage an extension coupling surface on the outer sleeve upon relative. A securement member including cooperative surfaces is defined adjacent the distal end of the inner and outer sleeves that is operable upon relative radially secure the sleeves together to thereby maintain the engagement of the screw engaging member and the bone screw.

Abstract: A method of attaching an extension to a bone anchor for use in percutaneous spinal surgery is provided that comprises the steps of: providing a bone anchor including a first portion for attachment to a vertebra and a second portion for attachment to a connecting element, the bone anchor including an extension coupling surface; providing an elongate hollow extension having a distal end and a proximal end, the extension having a rotationally movable anchor engaging member projecting radially from the distal end thereof; placing the distal end of the extension adjacent the bone anchor; and rotating the anchor engaging member to engage the extension coupling surface on the anchor and couple the extension and the bone anchor.

Abstract: An introducer is provided for inserting a connecting rod into tissue of a spine that comprises an outer sleeve with an actuatable rod attachment portion at a distal end thereof to releasably pivotally attach to a connecting rod, and an elongate inner shaft movable translationally within the outer sleeve. The proximal end of the shaft is coupled to an actuation mechanism for selectively translating the inner shaft. The distal end of the shaft includes a rod engagement surface that is movable y the actuation mechanism to a first position to engage a cooperative engagement surface on the rod to hold the rod in a selected locked orientation, to a second position to space the rod engagement surface from the cooperative engagement surface of the rod to allow pivoting of the rod, and to a third position to release the rod from the outer sleeve.

Abstract: A method of attaching a curved rod to a plurality of pedicle screws in the thoracic region of the spine is disclosed. Preferably, the method is practiced in a procedure for percutaneously fixing the rod to the pedicle screws through slots formed through a plurality of screw extensions releasably attached respectively to the pedicle screws. The method includes the steps of releasably and pivotally attaching the curved rod to a rod introducer having a handle and holding the rod initially in a fixed position. The rod is introduced in the fixed position through the slots in the extensions with the rod curvature defining a lordotic angle relative to the spine. The rod is released from the fixed position without separating the rod from the introducer. While the rod is in the released position the handle is rotated 180° thereby rotating the rod to a kyphotic angle relative to the thoracic region of the spine.

Abstract: An apparatus for detecting the presence of a connecting rod during percutaneous spinal surgery comprises a tubular member and an elongate strip extending therethrough. The strip has a flag at the proximal end and an elastically flexible rod detection tip projecting outwardly from the distal end for contacting a connecting rod. The strip is supported in the tubular member for pivoting movement relative to the longitudinal axis of the member. A biasing member biases the strip to a first position in which the flag is adjacent a first side of the tubular member and the detection tip at the distal end is adjacent an opposite second side. Upon application of a force to elastically flex the detection tip, in which the force is sufficient to overcome the bias, the flag is shifted to a second position adjacent the second side of the tubular member.

Abstract: A surgical instrument for the distraction or compression of bones or bone portions comprises a pair of elongate cross members pivotally coupled for relative movement having at one end a respective pair of handles and at the other end a respective pair of jaws. The jaws are generally parallel to each other and define a first plane within which the jaws are relatively movable, the space on both sides of the plane defining a work space between the jaws. The instrument further comprises a fulcrum supported by at least one of the cross members projecting into the work space and having an axis spaced from the jaws.

Abstract: A screwdriver for driving a multi-axial bone screw into a vertebra of the spine in one configuration includes an elongate shaft defining a driving tip at its distal end for engaging the head of the bone screw for joint rotational movement. The screw driver also includes an outer sleeve within which the inner shaft rotates freely. The outer retention sleeve releasably attaches to the yoke of the bone screw. Rotation of the inner shaft enables rotation of the bone screw threaded shank while the outer sleeve and yoke remain fixed. In another configuration, instead of the outer retention sleeve the screwdriver comprises a screw engagement member affixed to the shaft for joint rotational movement therewith, the screw engagement member comprising a stop sized to seat within a slot of the bone screw yoke, the stop being configured to rotate the yoke upon rotation shaft. A releasable retention member is provided on the screw engagement member for releasably attaching the screwdriver to the bone screw.

Abstract: Computer-based systems and methods for programmatically generating code, such as Structure Query Language (SQL) code, to perform an operation on a database. A code generation engine, referred to herein as an Alchemy engine, receives a request in a first language, such as an XML-based language, and translates the request into a second language, such as an SQL-based language. The translation process utilizes information stored in a metadata database.

Abstract: The present invention is a method for making a film cassette end plate and a film cassette comprises two end plates. The uncoated end plates are formed using one of several known plastic forming methods. The end plates are coated with an inorganic coating to impart smoothness and hardness to facilitate film handling and reduce wear. The end plates are mounted on a shaft to form a cassette.

Abstract: A cassette for supporting a film during a gaseous vapor deposition process includes a central shaft having first and second end plates. A rib on each end plate forms a spiral groove able to accept an edge of a film. Each rib has a cross sectional configuration having substantially linear major edges, a predetermined width dimension and a predetermined average thickness dimension, and a width-to-thickness aspect ratio of at least 2:1. The rib could be substantially rectangular with an optional flow spoiler at the free end or substantially wedge-shaped. The interspoke spacing between end plates is at least three hundred millimeters (300 mm) and is also greater than the width dimension of a film substrate at a gaseous deposition temperature. The width dimension of each rib is between about 0.5% to about 2.0% of the interspoke spacing.

Abstract: A vapor deposition apparatus includes an insert within which a material is deposited on the surface of a film. A cassette includes end plates each having a rib that edgewise receive a spiral wrapping of a film at least 300 mm wide. Spaces between turns of the wrapping define a gas flow channel and spaces between adjacent turns of one rib define inlet openings that communicate with the channel. Each rib has a predetermined width dimension, a predetermined average thickness dimension, and a width-to-thickness aspect ratio of at least 2:1. The spacing between end plates is at least 300 mm and is also greater than the film width at deposition temperature. The width dimension of each rib is between about 0.5% to about 2.0% of the end plate spacing. A diverging flow director contacts one end plate to directing gaseous fluid toward the inlet openings in that end plate.

Abstract: A cassette for supporting a film during a gaseous vapor deposition has first and second end plates. A rib on each end plate forms a spiral groove that edgewise receives a spiral wrapping of a film having a width greater than 300 mm. Spaces between turns of the film wrapping define a gas flow channel and spaces between adjacent turns of the rib define a plurality of inlet openings in one end plate that communicate with the channel. Each rib has a predetermined width dimension, a predetermined average thickness dimension, and a width-to-thickness aspect ratio of at least 2:1. The spacing between end plates is at least three hundred millimeters (300 mm) and is also greater than the width dimension of a film substrate at a gaseous deposition temperature. The width dimension of each rib is between about 0.5% to about 2.0% of the end plate spacing.

Abstract: A method and assembly is provided for linking an additional vertebral construct to an existing spinal construct having at least two bone screws engaged to corresponding vertebrae and connected by a connecting member. The assembly includes a fastener configured to engage a bone screw of the existing construct and to engage a connecting member connected to the bone screw. The assembly further includes a linking member having an elongated portion configured to connect to a bone screw of the additional construct and a mounting structure configured for mounting on the bone screw of the existing construct. A locking member fixes the orientation of the linking member relative to the bone screw and a clamping member locks the linking member and existing connecting member to the bone screw of the existing construct.

Abstract: An apparatus, a closed-loop system and method for measuring the resistance of inhalation systems and/or devices are disclosed.

Abstract: An apparatus for processing data 2 is provided with a time-to-digital converter 18 which serves to measure signal processing delay through one or more signal paths through a processing stage. This measured delay generates a delay value representing a plurality of instances of the signal processing delay which have been measured. Analysis is performed under software control to estimate a worst case signal processing delay through the processing stage based upon the delay values which have been generated. An adjustment of the operating parameters, such as supply voltage and clock frequency, of the apparatus is made to provide a timing margin through the processing stage sufficient to satisfy the worst case signal processing delay which has been estimated without an excessive margin.

Abstract: Described herein are interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The devices can be used in a wired or wireless communication mode to communicate with a display to assess the subject's usage of the inhalation system, to evaluate the performance of the inhalation system and/or to detect the characteristics profile of a dry powder formulation emitted from the inhalation system in use.

Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

Abstract: A new and distinct cultivar of Syzygium plant named ‘Big Red’, characterized by its upright to bushy to outwardly spreading plant habit; relatively large leaves that are initially greyed orange in color; developing stems are greyed purple in color; and good garden performance.