Abstract: The present application provides TILs comprising agents that enhance activity and/or proliferative capacity of the TILs, methods of manufacturing such TILs. and methods of using such modified TILs for enhancing an immune response.

Abstract: A method and apparatus for automatically sensing the configuration of a damaged surface area and wherein the apparatus is provided with an arc gouging tool, a welding tool, and a grinding tool to gouge damaged areas and fill them with weld material to at least the surface profile of the surface in the working environment and to grind the filled areas flush with the surface of the working environment. A track is bent to a profile enabling the apparatus to work without any collision with its environment while keeping full access to the work area. The geometry of the track is generally unknown to the control circuit of the robot. A motor-actuated robot member is connected to the track and is displaceable on the track by a motorized element. A working arm is displaceably coupled to the robot member and has one or more working tools connected thereto. A control circuit displaces the robot and operates the working arm and tool.