Abstract: Devices, systems, and methods are provided for recognizing, diagnosing, mapping, sensing, monitoring and/or treating selected areas within a patient's body. The systems, devices and methods may be used to map, detect and/or quantify images and/or physiological parameters collected from the patient. One such system comprises an optical imaging device, such as an endoscope, and a processor coupled to the imaging device. The processor includes a software application configured to recognize the images captured by the optical imaging device and determine if the tissue contains a medical condition and may include an artificial neural network configured to develop at least one set of computer-executable rules useable to recognize the medical condition in the captured tissue images. The systems, devices and methods provided herein allow for a more objective and comprehensive inspection of the targeted areas within a patient so as to improve the diagnosis and ultimate treatment of patients.

Abstract: Lubricant compositions comprising an oil of lubricating viscosity and a viscosity modifier that is a hydrocarbon polymer having a number average molecular weight (Mn) of less than 10,000 Daltons (Da). The viscosity modifier is present at greater than 2 wt %, based on a total weight of the lubricant composition. Exemplary hydrocarbon polymers include, but are not limited to, olefin polymers, such as polyisobutylene polybutene, ethylene ?-olefin copolymers, or combinations thereof.

Abstract: Devices and methods for cleaning and/or drying endoscopic instruments, such as endoscopes, are provided. A drying device for use with an endoscopic instrument comprises an elongate member configured for advancement through an internal lumen within the endoscopic instrument and a drying member removably coupled to a portion of the elongate member. The drying element comprises a variable pressure region shaped and configured to increase the hydrodynamic fluid friction force and fluid pressure force applied to the wall of the internal lumen of the endoscope to more effectively remove all of the moisture and fluid from the internal surfaces of an endoscopic instrument.

Abstract: A pump and heater assembly can include an electric motor, a pump, an electric heater module, a control module, and a flowpath (F). The electric heater module can include a housing, a plurality of heater elements, and a plurality of heat exchange elements each having a primary heat transfer surface and projecting secondary heat transfer surfaces. The flowpath passes from an inlet to the pump, then to the electric heater module, and then to an outlet. The flowpath further passes through a first manifold and a second manifold that are fluidically connected to a plurality of fluidically parallel portions (F1 to Fn) of the flowpath, at least one of which passes along each of the heat exchange elements.

Abstract: Tools and systems for the delivery of medical devices or components, and more specifically, to tools and systems that assist or facilitate the delivery of one or more medical device or component over, onto, into, or against, another medical device or component are provided. More specifically, delivery tools and systems for the placement of an endoscopic device over, onto, into, or against, another instrument or endoscope are provided.

Abstract: Devices and methods for cleaning and/or drying endoscopic instruments, such as endoscopes, are provided. A drying device for use with an endoscopic instrument comprises an elongate member configured for advancement through an internal lumen within the endoscopic instrument and a drying member removably coupled to a portion of the elongate member. The drying element comprises a variable pressure region shaped and configured to increase the hydrodynamic fluid friction force and fluid pressure force applied to the wall of the internal lumen of the endoscope to more effectively remove all of the moisture and fluid from the internal surfaces of an endoscopic instrument.

Abstract: An endoscope accessory, such as a coupler device, is provided that includes a main body with a visualization section for allowing viewing of tissue by the endoscope and a proximal end configured for attachment to a distal end portion of the endoscope. The device includes a passage within the main body having an open distal end and a proximal end aligned with the working channel of the endoscope. A locking element on the coupler device secures an angle of exit of an instrument passing through the passage.

Abstract: The present disclosure relates to compositions comprising lipid nanoparticles for delivering nucleic acid molecules into cells. Also included are methods for producing and using such compositions.

Abstract: A coupler device for an endoscope that includes a main body having a proximal end configured to attach to the distal end portion of the endoscope, and a protective cover to reduce the ingress of debris, fluid, bacteria, or other unwanted matter from the working end of the endoscope which could lead to infection and decreased performance of the scope. The coupler device further includes a visualization section on the main body between the camera lens and light source of the endoscope and the target site within the patient. The visualization section includes one or more optical components configured to reduce an amount of reflected light from the surface and/or to inhibit condensation of water droplets on the surface. Reducing the glare and/or fogging of the visualization section significantly improves the surgeon's view of the target site through the optical coupler.

Abstract: A kit for use in an endoscopic procedure on a patient comprises a device for use in the endoscopic procedure, such as an external accessory device for an endoscope or an endoscopic device configured for advancement through an opening into a patient. The kit further includes a coupler device for an endoscope that comprises a main body having a proximal end configured to attach to the distal end portion of the endoscope, and a mechanism for articulating an instrument passing through the endoscope so that instruments can exit the endoscope at various angles. The coupler device also provides a protective cover to reduce the ingress of debris, fluid, bacteria, or other unwanted matter from the working end of the endoscope which could lead to infection and decreased performance of the scope.

Abstract: A corrugated fiberboard blank and container formed therefrom includes an interior portion and an exterior portion that are combined form a doubled-wall construction, in at least some portions of the container. In certain embodiments, the interior portion is hingedly coupled to the exterior portion, and a first front side wall comprises a first removable panel, a second front side wall comprises a second removable panel, and a first top section comprises a third removable panel.

Abstract: Devices and methods for cleaning and/or drying endoscopic instruments, such as endoscopes, are provided. A drying device for use with an endoscopic instrument comprises an elongate member configured for advancement through an internal lumen within the endoscopic instrument and a drying member removably coupled to a portion of the elongate member. The drying element comprises a variable pressure region shaped and configured to increase the hydrodynamic fluid friction force and fluid pressure force applied to the wall of the internal lumen of the endoscope to more effectively remove all of the moisture and fluid from the internal surfaces of an endoscopic instrument.

Abstract: A camera captures an image of a portion of a cart and accesses stored maps that map visual features of carts to a set of settings that are applied to an automatic fill control system. A map that matches visual features of the cart, in the captured image, is identified and the settings in that map are applied to the automatic fill control system.

Abstract: An endoscope accessory, such as a coupler device, is provided that includes a main body with a visualization section for allowing viewing of tissue by the endoscope and a proximal end configured for attachment to a distal end portion of the endoscope. The device includes a passage within the main body having an open distal end and a proximal end aligned with the working channel of the endoscope. A locking element on the coupler device secures an angle of exit of an instrument passing through the passage.

Abstract: Devices, systems, and methods for delivering therapeutic agents for nerve stimulation are used to administer a therapeutic agent to a patient, modulate one or more nerves of the patient, and optionally monitor patients' physiological parameters. The monitoring can inform the nerve modulation and/or administration of the therapeutic agent. Systems, apparatus, and methods deliver therapeutic agents for nerve stimulation. Devices administer therapeutic agents, modulate patients' nerve(s), and observe and track patient physiological parameters. Modulation can be performed during and/or after administration of a therapeutic to the patient. Targeted compounds activate peripheral nerves including via agonists of chemoreceptors or somatosensory receptors resulting in signaling in the cervical vagus nerve.

Abstract: A device having an optical element with a conductive coating. The device may include an optical element, a conductive material and at least one connector. The conductive material is disposed on at least a portion of the optical element. The optical element, for example, may be an object lens of an endoscope or an optical coupler. The connectors (acting as terminal(s)) are capable of providing energy (such as electrical energy) to the conductive material. In one aspect, the conductive material is an optically transparent material. Advantageously, the device may allow visualization of an object—such as body tissue or other matter—concurrent with the application of energy to the object via the conductive coating. This allows the user to observe the alteration of tissue and other matter in real time as the energy is delivered.

Abstract: A pump and heater assembly can include an electric motor, a pump, one or more resistive heater elements, a control module with switching electronics usable to control operation of the electric motor, and a flowpath through which a coolant fluid is flowable fluidically passing to a first manifold downstream of the pump, to both first and second flowpath segments branching from the first manifold, and to a second manifold downstream of both the first and second flowpath segments. The first flowpath segment passes proximate to the heater elements to enable heating of a portion of the coolant fluid present in the first flowpath segment. The second flowpath segment passes through the control module proximate to the switching electronics to enable cooling of the switching electronics by a portion of the coolant fluid present in the second flowpath segment. The first and second flowpath segments can be arranged fluidically in parallel.

Abstract: A coupler device for a forward viewing endoscope comprises a main body having a proximal end configured to attach to the distal end portion of the endoscope and a distal end portion that at least partially seals the distal end portion of the scope and allows for viewing of the surgical site. The coupler device may include a flexible working channel extension for attachment to the working channel of the endoscope. The coupler device provides a protective cover to reduce the ingress of debris, fluid, bacteria, or other unwanted matter from the working end of the endoscope which could lead to infection and decreased performance of the scope. A kit for use in an endoscopic procedure on a patient comprises the coupler device and an end viewing endoscope having a working channel, a light and a camera lens.

Abstract: A blank for use in forming a container, such as a corrugated fiberboard container, can include a reinforcement portion that provide improved structural integrity for a display ready container. The reinforcing portion can include at least a first front wall reinforcement portion and a second front wall reinforcement portion, with the first and second front wall reinforcement portions being spaced apart from one another. The front wall and a front top section can have removable panels when used as a display container.

Abstract: Disclosed is a navigation system with a remote visualization element for navigating in remote spaces in medical and non-medical applications using multiple imaging modalities, including direct visualization.