Abstract: A system and method for determining a direction of travel of a vehicle and/or identifying a misplaced wayside device obtain location data from wayside devices. The location data are representative of locations of the wayside devices along a route being traveled by a vehicle. The system and method also determine whether the location data in a series of the wayside devices exhibit an increase or a decrease in the location data across the wayside devices in the series and, responsive to determining whether the location data in the series of the wayside devices does exhibit the increase or the decrease in the location data, the system and method determine a direction of travel of the vehicle along the route, determine a location of the vehicle along the route, and/or identify a misplaced wayside device.

Abstract: Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.

Abstract: A latch assembly for driving a closure panel from a closed panel position to an open panel position.

Abstract: Certain imidazopyridines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.

Abstract: A skate shield for use with ice skates. The skate shield includes a rigid shell made at least of outer and inner layers of fiber reinforced plastic or polymer (FRP), and a fastener assembly for releasably securing the shell to a boot portion of the ice skate. The shell includes a medial side portion interconnected to a lateral side section via a top portion. A reinforced section formed by reinforcing layers laminated between the outer and inner layers is provided in at least one of the medial side portion and the lateral side portion of the shell.

Abstract: Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in intro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: An electromagnetic system for a powered vehicle door for driving the door forward and/or backward between open and closed positions is provided. The electromagnetically driven sliding door includes a door panel with at least one permanent first magnet fixed to the door panel. A plurality of electromagnetic coils are operably mounted adjacent the door panel. The electromagnetic coils are configured in electrical communication with a source of electric current of alternating first and second polarities. The electromagnetic coils are energizable via the electric current to attract the at least one first permanent magnet in response to the first polarity electric current and to repel the at least one first permanent magnet in response to the second polarity electric current to drive the door panel between open and closed positions. Permanent pole magnets can be incorporated to facilitate supporting the door within a door track of the door.

Abstract: A variable resistance conductive rubber sensor and method of detecting an object/human touch therewith is provided. The sensor has a sensor body constructed from electrically conductive rubber. The sensor body extends between opposite first and second ends. A first wire is operably connected to the first end and a second wire may be operably connected to the second end, with the first and second wires being brought into electrical communication with one another by the intermediately extending electrically conductive rubber of the sensor body. A microcontroller is operably connected to the sensor body to detect the presence of an applied force or human touch on the sensor body.

Abstract: Certain pyrazolo[1,5-a]pyrimidines: or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.

Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein R1, R2, R3, and R4 are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk. In certain embodiments, also disclosed are methods for treating a cancer in a subject (e.g., a human) in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof, in combination with a vinca-alkaloid, or a pharmaceutically acceptable salt thereof.

Abstract: Certain imidazopyridines (I) and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.

Abstract: The invention relates to analyzing social media users, including their locations visited and behavioral information, based on social media content items posted from monitored locations, according to an implementation of the invention. The system may monitor a specified location and identify a user of interest who posts a social media content item from or in association with the specified location. Once the system identifies a user of interest, the system may aggregate other social media content items posted by the user of interest (e.g., from different locations and/or at different times). The system may also aggregate and analyze the behavior and interests of populations of users in order to develop customer “personas” that inform and inspire marketing and advertising professionals who tailor advertising and messaging to broad audiences.

Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein X1, X2, X3, R2, R3, R4, R5, and Y are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.

Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein R1, R2, R3, and R4 are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk. In certain embodiments, also disclosed are methods for treating a cancer in a subject (e.g., a human) in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof, in combination with a vinca-alkaloid, or a pharmaceutically acceptable salt thereof.

Abstract: Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: A system and method for determining a direction of travel of a vehicle and/or identifying a misplaced wayside device obtain location data from wayside devices. The location data are representative of locations of the wayside devices along a route being traveled by a vehicle. The system and method also determine whether the location data in a series of the wayside devices exhibit an increase or a decrease in the location data across the wayside devices in the series and, responsive to determining whether the location data in the series of the wayside devices does exhibit the increase or the decrease in the location data, the system and method determine a direction of travel of the vehicle along the route, determine a location of the vehicle along the route, and/or identify a misplaced wayside device.

Abstract: The invention relates to systems and methods of identifying social media influencers and providing location-based alerts based on social media content items posted to social media providers from monitored locations. The system may identify a user who visited a specified location based on a social media content item posted by the user from the specified location. The system may provide an alert to an entity such as a retailer whenever the user re-posts from the specified location. The system may further determine whether, to what extent, and identity of users over whom the user has influence based on one or more influence factors. An influencer is a user who is determined to have influenced the behavior of other users, as determined from the user's social media activity and/or the influenced users' social media activity.

Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein R1, R2, R3, and R4 are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts or co-crystals thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.

Abstract: A tire inflation apparatuses is provided for maintaining a predetermined inflation pressure of a pair of tires mounted a dual wheel unit of a vehicle. The apparatus includes a first and a second pump unit that are connected to a housing that includes a mounting structure for engaging a complementary mounting structure of the dual wheel unit. The first and second pump include first and second pump rods configured to translate in response to rotation of the dual wheel unit. A gearset and an eccentric drive mechanism are arranged to reciprocate the first and second pump rods.

Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein X1, X2, X3, R2, R3, R4, R5, and Y are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.