Patents by Inventor Scott MYRAND

Scott MYRAND has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250084470
    Abstract: A method for detecting a gene fusion includes amplifying a nucleic acid sample in the presence of primer pool to produce a plurality of amplicons. The primer pool includes primers targeting a plurality of exon-exon junctions of a driver gene. The amplicons correspond to the exon-exon junctions. The amplicons are sequenced and aligned to a reference sequence. The number of reads corresponding to each amplicon is normalized to give a normalized read count. A baseline correction is applied to the normalized read counts for the amplicons to form corrected read counts. A binary segmentation score is calculated for each corrected read count. A predicted breakpoint for the gene fusion is determined based on the amplicon index corresponding to the maximum absolute binary segmentation score. Gene fusion events may be detected in a partner agnostic manner, i.e. without prior knowledge of the specific fusion partner genes or specific breakpoint information.
    Type: Application
    Filed: September 25, 2024
    Publication date: March 13, 2025
    Inventors: Rajesh Gottimukkala, Amir Marcovitz, Jeoffrey Schageman, Varun Bagai, Jian Gu, James Veitch, Kelli Bramlett, Scott Myrand, Fiona Hyland, Seth Sadis, Paul Williams
  • Patent number: 12139753
    Abstract: A method for detecting a gene fusion includes amplifying a nucleic acid sample in the presence of primer pool to produce a plurality of amplicons. The primer pool includes primers targeting a plurality of exon-exon junctions of a driver gene. The amplicons correspond to the exon-exon junctions. The amplicons are sequenced and aligned to a reference sequence. The number of reads corresponding to each amplicon is normalized to give a normalized read count. A baseline correction is applied to the normalized read counts for the amplicons to form corrected read counts. A binary segmentation score is calculated for each corrected read count. A predicted breakpoint for the gene fusion is determined based on the amplicon index corresponding to the maximum absolute binary segmentation score. Gene fusion events may be detected in a partner agnostic manner, i.e. without prior knowledge of the specific fusion partner genes or specific breakpoint information.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: November 12, 2024
    Assignee: Life Technologies Corporation
    Inventors: Rajesh Gottimukkala, Amir Marcovitz, Jeoffrey Schageman, Varun Bagai, Jian Gu, James Veitch, Kelli Bramlett, Scott Myrand, Fiona Hyland, Seth Sadis, Paul Williams
  • Publication number: 20200318175
    Abstract: A method for detecting a gene fusion includes amplifying a nucleic acid sample in the presence of primer pool to produce a plurality of amplicons. The primer pool includes primers targeting a plurality of exon-exon junctions of a driver gene. The amplicons correspond to the exon-exon junctions. The amplicons are sequenced and aligned to a reference sequence. The number of reads corresponding to each amplicon is normalized to give a normalized read count. A baseline correction is applied to the normalized read counts for the amplicons to form corrected read counts. A binary segmentation score is calculated for each corrected read count. A predicted breakpoint for the gene fusion is determined based on the amplicon index corresponding to the maximum absolute binary segmentation score. Gene fusion events may be detected in a partner agnostic manner, i.e. without prior knowledge of the specific fusion partner genes or specific breakpoint information.
    Type: Application
    Filed: March 20, 2020
    Publication date: October 8, 2020
    Inventors: Rajesh GOTTIMUKKALA, Amir MARCOVITZ, Jeoffrey SCHAGEMAN, Varun BAGAI, Jian GU, James VEITCH, Kelli BRAMLETT, Scott MYRAND, Fiona HYLAND, Seth SADIS, Paul WILLIAMS