Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.

Abstract: Oxidase-based sensors and methods of using the sensors are provided.

Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.

Abstract: A golf mat that has a natural feel and mitigates injury during mat striking includes: a base, the base including a main structure with an upper surface and an open topped cavity in the upper surface; and an insert sized to be accommodated in the cavity, the insert including a layer of solid polymeric material selected to have shock absorption properties greater than the main structure; and artificial turf installed on the base and overlying at least a portion of the main structure and the insert.

Abstract: A method comprises reacting an aluminum feedstock with an acid in the presence of water to provide an aluminum salt solution comprising an aluminum salt in water, wherein the aluminum salt comprises a reaction product of the acid and aluminum, and spray roasting the aluminum salt solution at a temperature of at least about 450° C. to provide an aluminum oxide powder, wherein the spray roasting is performed in a furnace lined with a refractory comprising alumina that is at least about 99.2% purity alumina, and wherein the aluminum oxide powder is 99.2% pure aluminum oxide or greater.

Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.

Abstract: A golf practise mat including a stance section and a ball strike section. The stance section is segmented into a plurality of planar components so that the golf may can be disassembled for shipping and storage. A kit is disclosed including the components and instructions for assembly. A golf practise mat may also have one or more swing training devices for installation of golf training rods.

Abstract: Oxidase-based sensors and methods of using the sensors are provided.

Abstract: Layered implantable sensors are described herein. Layered sensors described herein may include one or more analyte sensing populations. The one or more analyte sensing populations may detect different analytes, or different concentrations of the same analyte, for example. The layered sensors may include a reference population. The reference population may, or may not, be analyte sensing. As described herein, the first sensing population may be separated from a second sensing population (and/or a reference population) by a passive layer.

Abstract: A golf mat that has a natural feel and mitigates injury during mat striking includes: a base, the base including a main structure with an upper surface and an open topped cavity in the upper surface; and an insert sized to be accommodated in the cavity, the insert including a layer of solid polymeric material selected to have shock absorption properties greater than the main structure; and artificial turf installed on the base and overlying at least a portion of the main structure and the insert.

Abstract: A method comprises reacting an aluminum feedstock with an acid in the presence of water to provide an aluminum salt solution comprising an aluminum salt in water, wherein the aluminum salt comprises a reaction product of the acid and aluminum, and spray roasting the aluminum salt solution at a temperature of at least about 450° C. to provide an aluminum oxide powder, wherein the spray roasting is performed in a furnace lined with a refractory comprising alumina that is at least about 99.2% purity alumina, and wherein the aluminum oxide powder is 99.2% pure aluminum oxide or greater.

Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.

Abstract: A method comprising (a) reacting aluminum metal with an acid in the presence of water to provide a first aluminum salt solution comprising an aluminum salt in water, wherein the aluminum salt comprises a reaction product of the acid and the aluminum metal, (b) heating the first aluminum salt solution to provide a mother liquor and solid aluminum salt, (c) optionally, separating the solid aluminum salt from the mother liquor, (d) optionally, dissolving at least a portion of the separated solid aluminum salt with water to provide a second aluminum salt solution, (e) spray roasting the first, or second (if produced), aluminum salt solution to provide an aluminum oxide powder, and (f) washing the aluminum oxide powder, wherein the washed aluminum oxide powder comprises less than about 30 ppmw total metallic and alkyl impurities.

Abstract: A method comprising (a) reacting aluminum metal with an acid in the presence of water to provide a first aluminum salt solution comprising an aluminum salt in water, wherein the aluminum salt comprises a reaction product of the acid and the aluminum metal, (b) heating the first aluminum salt solution to provide a mother liquor and solid aluminum salt, (c) optionally, separating the solid aluminum salt from the mother liquor, (d) optionally, dissolving at least a portion of the separated solid aluminum salt with water to provide a second aluminum salt solution, (e) spray roasting the first, or second (if produced), aluminum salt solution to provide an aluminum oxide powder, and (f) washing the aluminum oxide powder, wherein the washed aluminum oxide powder comprises less than about 30 ppmw total metallic and alkyl impurities.

Abstract: A method comprising contacting high-purity acid, high-purity aluminum, and high-purity water to form a first solution in a heated non-contaminating vessel, wherein the aluminum is employed in at least a stoichiometric amount relative to the acid, heating the first solution in a non-contaminating container, to provide a mother liquor and solid aluminum salts, separating the solid aluminum salts from the mother liquor, heating the solid aluminum salts in a non-contaminating crucible, to provide alpha aluminum oxide, and, optionally, washing the alpha aluminum oxide with high-purity water after some or all of the heating of the solid aluminum salts to provide the alpha aluminum oxide.

Abstract: A golf practise mat including a stance section and a ball strike section. The stance section is segmented into a plurality of planar components so that the golf may can be disassembled for shipping and storage. A kit is disclosed including the components and instructions for assembly. A golf practise mat may also have one or more swing training devices for installation of golf training rods.