Patents by Inventor Scott P. Fulton
Scott P. Fulton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8920645Abstract: Described is a disposable valve that includes an actuation layer operationally linked to a flexible diaphragm; a valving layer operationally linked to the flexible diaphragm; and a connection layer operationally connected to the valving layer; wherein the valving layer and the connection layer have a corresponding plurality of channels passing therethrough, and the channels define at least one fluid flow path, and the flexible diaphragm is movable between a first open position wherein fluid can flow through the fluid flow path, and a second closed position wherein fluid cannot flow through the fluid flow path. Chromatographic systems incorporating a plurality of such valves, optionally integrated into a unitary valve block, are also described.Type: GrantFiled: December 7, 2006Date of Patent: December 30, 2014Assignee: Tarpon Biosystems Inc.Inventors: Michael G. Moran, Scott P. Fulton
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Patent number: 8802026Abstract: The present invention relates to an improved system for efficiently and accurately performing immunoassays, such as ELISAs. The invention provides an immunoassay assembly which includes a flow-through unit and an aspiration pump. The immunoassay flow-through unit includes an outer seal; at least one bed support; an inner seal; and a packed non-porous bed. The unit is releasably attached to an aspiration pump which enables the controlled flow rate of liquid passing through the packed bed of the flow-through unit. The invention also provides a method of using the immunoassay assembly to identify analytical targets of interest.Type: GrantFiled: August 19, 2010Date of Patent: August 12, 2014Assignee: Agilent Technologies, Inc.Inventors: Scott P. Fulton, Robert J. Sakowski, William Bowers
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Publication number: 20130171658Abstract: The invention provides more rapid and cost-effective methods of deglycosylating target glycoproteins. In methods of the invention, the target glycoprotein is isolated from initial samples, which may contain multiple other glycoproteins, by subjecting the initial sample to a solid phase containing an affinity ligand, such as a deglycosylated antibody, that interacts specifically with the target glycoprotein. Once separated from the sample, the target glycoprotein can be deglycosylated in situ, or eluted from the solid phase, quantitated, and then deglycosylated.Type: ApplicationFiled: September 15, 2011Publication date: July 4, 2013Applicant: PROZYME, INC.Inventors: Scott P. Fulton, Steven M. Murphy
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Patent number: 8158064Abstract: The present invention relates to an improved system for efficiently and accurately performing immunoassays, such as ELISAs. The invention provides an immunoassay assembly which includes a flow-through unit and an aspiration pump. The immunoassay flow-through unit includes an outer seal; at least one bed support; an inner seal; and a packed non-porous bed. The unit is releasably attached to an aspiration pump which enables the controlled flow rate of liquid passing through the packed bed of the flow-through unit. The invention also provides a method of using the immunoassay assembly to identify analytical targets of interest.Type: GrantFiled: August 3, 2009Date of Patent: April 17, 2012Assignee: Agilent Technologies, Inc.Inventors: Scott P. Fulton, Robert J. Sakowski, William Bowers
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Patent number: 8124028Abstract: The present invention provides a novel system for efficiently and accurately analyzing targets in samples and for preparing samples for analysis with various analytical methods. A version of the present invention comprises a multi-function probe, configured for pipetting liquids directly, with a pipet tip, or with an assay unit described herein. Another version of the present invention includes an apparatus for conducting an immunoassay or selective adsorption separation comprising an assay unit and a multi-function probe. Another version of the present invention includes a multi-function probe and assay unit for use with an automated Cartesian robot. Other versions include one- or two-dimensional arrays comprising multi-function probes connected to syringe barrels for use with assay units.Type: GrantFiled: December 19, 2008Date of Patent: February 28, 2012Assignee: Agilent Technologies, Inc.Inventors: Scott P. Fulton, Robert J. Sakowski
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Publication number: 20110020919Abstract: The present invention provides a novel system for efficiently and accurately analyzing targets in samples and for preparing samples for analysis with various analytical methods. A version of the present invention comprises a multi-function probe, configured for pipetting liquids directly, with a pipet tip, or with an assay unit described herein. Another version of the present invention includes an apparatus for conducting an immunoassay or selective adsorption separation comprising an assay unit and a multi-function probe. Another version of the present invention includes a multi-function probe and assay unit for use with an automated Cartesian robot. Other versions include one- or two-dimensional arrays comprising multi-function probes connected to syringe barrels for use with assay units.Type: ApplicationFiled: December 19, 2008Publication date: January 27, 2011Inventors: Scott P. Fulton, Robert J. Sakowski
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Publication number: 20100323372Abstract: The present invention relates to an improved system for efficiently and accurately performing immunoassays, such as ELISAs. The invention provides an immunoassay assembly which includes a flow-through unit and an aspiration pump. The immunoassay flow-through unit includes an outer seal; at least one bed support; an inner seal; and a packed non-porous bed. The unit is releasably attached to an aspiration pump which enables the controlled flow rate of liquid passing through the packed bed of the flow-through unit. The invention also provides a method of using the immunoassay assembly to identify analytical targets of interest.Type: ApplicationFiled: August 19, 2010Publication date: December 23, 2010Inventors: Scott P. Fulton, Robert J. Sakowski, William Bowers
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Patent number: 7799279Abstract: The present invention relates to an improved system for efficiently and accurately performing immunoassays, such as ELISAs. The invention provides an immunoassay assembly which includes a flow-through unit and an aspiration pump. The immunoassay flow-through unit includes an outer seal; at least one bed support; an inner seal; and a packed non-porous bed. The unit is releasably attached to an aspiration pump which enables the controlled flow rate of liquid passing through the packed bed of the flow-through unit. The invention also provides a method of using the immunoassay assembly to identify analytical targets of interest.Type: GrantFiled: July 25, 2005Date of Patent: September 21, 2010Assignee: Biosystem Development, LLCInventors: Scott P. Fulton, Robert J. Sakowski, William Bowers
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Publication number: 20100173330Abstract: The present invention relates to an improved system for efficiently and accurately performing immunoassays, such as ELISAs. The invention provides an immunoassay assembly which includes a flow-through unit and an aspiration pump. The immunoassay flow-through unit includes an outer seal; at least one bed support; an inner seal; and a packed non-porous bed. The unit is releasably attached to an aspiration pump which enables the controlled flow rate of liquid passing through the packed bed of the flow-through unit. The invention also provides a method of using the immunoassay assembly to identify analytical targets of interest.Type: ApplicationFiled: August 3, 2009Publication date: July 8, 2010Inventors: Scott P. Fulton, Robert J. Sakowski, William Bowers
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Patent number: 7087719Abstract: The present invention relates to the purification and production of human albumin from various sources through crystallization and repeated crystallization. Basic features of the invented process include providing specific reaction conditions and precipitating reagents to maximize albumin crystallization. Solubility diagrams are utilized as the basis for process control of the invented method. The current invention specifically controls phosphate concentration, pH and temperature to precisely guide crystallization kinetics and crystal yield.Type: GrantFiled: November 19, 2002Date of Patent: August 8, 2006Assignee: GTC Biotherapeutics, Inc.Inventors: Kalevi Visuri, Sinikka Uotila, Scott P. Fulton, Daniel E. Couto
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Publication number: 20040102380Abstract: The present invention relates to an improved method to process, purify and/or produce biopharmaceuticals or other products involving automated blending of pH buffered solutions from water and common stocks of concentrated acids and bases, and other components. This approach reduces the cost and complexity of the solution preparation systems required for producing these solutions under aseptic or sterile conditions, and reduces the material costs of the solutions themselves. This approach is particularly beneficial to use with continuously-produced feedstocks and with continuous separation operations.Type: ApplicationFiled: November 18, 2003Publication date: May 27, 2004Inventors: Scott P. Fulton, Peter G. Brown
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Publication number: 20040097710Abstract: The present invention relates to the purification and production of human albumin from various sources through crystallization and repeated crystallization. Basic features of the invented process include providing specific reaction conditions and precipitating reagents to maximize albumin crystallization. Solubility diagrams are utilized as the basis for process control of the invented method. The current invention specifically controls phosphate concentration, pH and temperature to precisely guide crystallization kinetics and crystal yield.Type: ApplicationFiled: November 19, 2002Publication date: May 20, 2004Inventors: Kalevi Visuri, Sinikka Uotila, Scott P. Fulton, Daniel E. Couto
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Patent number: 6521131Abstract: The disclosed invention relates to a method of disposing of mercury-containing wastewater containing mercury-complexing materials, comprising the steps of treating wastewater containing mercury ions with a strong oxidizing agent in a reaction chamber to produce pretreated wastewater by removing an effluent stream of pretreated wastewater from the reaction chamber; and passing the effluent stream of pretreated wastewater through a column packed with a mercury-selective adsorbent material to produce an effluent stream of wastewater having a reduced mercury content. The adsorbent material is a porous resin having immobilized mercury-selective chelating groups bound thereto. A particularly preferred adsorbent material is a crosslinked styrene-divinylbenzene copolymer having immobilized dithiocarbamate groups bound thereto.Type: GrantFiled: July 15, 1999Date of Patent: February 18, 2003Assignee: SolmeteX, Inc.Inventors: Richard A. Hamilton, Scott P. Fulton, Ted M. Shields
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Patent number: 5108704Abstract: The present invention relates to a multiwell apparatus for biological and biochemical analysis which provides for separate collection of filtrate from each well, without cross-contamination therebetween. The present invention provides a manifold plate having an array of filtering wells, each of the wells being closed at its bottom by a planar bottom member providing a filter support surface. A discharge nozzle of passageway depends from each well bottom (planar bottom member) in a direction normal thereto, with one such discharge nozzle or port being provided in fluid communication with each filtering well. Each of these filtrate nozzles or drain ports extends from the lower surface of the planar bottom member to such an extent that it will enter into the well of a conventional multiwell, e.g., microtiter, plate in alignment therewith and mate with the sidewall of the aligned well of the multiwell plate.Type: GrantFiled: September 16, 1988Date of Patent: April 28, 1992Assignee: W. R. Grace & Co.-Conn.Inventors: William F. Bowers, Scott P. Fulton, Judith A. Thompson, David M. Donofrio, Kert F. Ivie
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Patent number: 4810392Abstract: A method and apparatus for supplying a preset amount of sample solution to a liquid chromatographic column wherein (1) a first piston, which moves along the axis of a piston container sealingly contacting the side walls of said piston container, is moved a preset distance so as to draw a fixed amount of driving solution from the driving solution chamber of a piston cylinder into the piston container, thus displacing a second piston which moves along the axis of said piston cylinder sealingly contacting the side walls of said piston cylinder and dividing said piston cylinder into a sample solution chamber and a driving solution chamber, said displacement of said second piston serving to cause sample solution to be drawn from a sample solution reservoir into the sample solution chamber of the piston cylinder in a fixed amount equal to the fixed amount of driving solution drawn into the piston container; and (2) driving solution is pumped into said driving solution chamber in order to displace said second pistonType: GrantFiled: December 17, 1987Date of Patent: March 7, 1989Assignee: W. R. Grace & Co.Inventors: Scott P. Fulton, Douglas B. Tiffany
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Patent number: 4734190Abstract: A method and apparatus for supplying a preset amount of sample solution to a liquid chromatographic column wherein (1) a first piston, which moves along the axis of a piston container sealingly contacting the side walls of said piston container, is moved a preset distance so as to draw a fixed amount of driving solution from the driving solution chamber of a piston cylinder into the piston container, thus displacing a second piston which moves along the axis of said piston cylinder sealingly contacting the side walls of said piston cylinder and dividing said piston cylinder into a sample solution chamber and a driving solution chamber, said displacement of said second piston serving to cause sample solution to be drawn from a sample solution reservoir into the sample solution chamber of the piston cylinder in a fixed amount equal to the fixed amount of driving solution drawn into the piston container; and (2) driving solution is pumped into said driving solution chamber in order to displace said second pistonType: GrantFiled: April 17, 1987Date of Patent: March 29, 1988Assignee: W. R. Grace & Co.Inventors: Scott P. Fulton, Douglas B. Tiffany