Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: Provided herein are compounds of formula (1): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Abstract: An emergency locator beacon testing and communication system is described. The system uses privately-owned Local User Terminals which provide direct feeds to a privately-operated beacon information processor having dedicated on-line servers for consolidating and providing access to beacon test information. The system receives beacon signals relayed through the Cospas-Sarsat satellite system, correlates the beacons' unique identification numbers (UIN's) in the received signals to the UIN's of beacons known to be undergoing testing, collects the data transmitted by beacons under test, and displays beacon test results in a useful format on a user-friendly website.

Abstract: An emergency locator beacon testing and communication system is described. The system uses privately-owned Local User Terminals which provide direct feeds to a privately-operated beacon information processor having dedicated on-line servers for consolidating and providing access to beacon test information. The system receives beacon signals relayed through the Cospas-Sarsat satellite system, correlates the beacons' unique identification numbers (UIN's) in the received signals to the UIN's of beacons known to be undergoing testing, collects the data transmitted by beacons under test, and displays beacon test results in a useful format on a user-friendly website.

Abstract: A mass occupant notification (MON) system includes an alert source, a first communication network, a MON supervisory system, a second communication network, a satellite radio broadcast network (SRBN) system and a plurality of MON communication units. The alert source, such as a telephone, personal computer or emergency sensor system, generates an alert signal containing information regarding an emergency situation. The first communication network communicates the alert signal from the alert source to the MON supervisory system. The MON supervisory system receives the alert signal and generates an alert message which includes audio message data and destination data. The destination data indicates a destination of the audio message data. The audio message data may contain a voice announcement providing information or instructions regarding the emergency situation. The second communication network communicates the alert message from the MON supervisory system to the SRBN system.

Abstract: A mass occupant notification (MON) system includes an alert source, a first communication network, a MON supervisory system, a second communication network, a satellite radio broadcast network (SRBN) system and a plurality of MON communication units. The alert source, such as a telephone, personal computer or emergency sensor system, generates an alert signal containing information regarding an emergency situation. The first communication network communicates the alert signal from the alert source to the MON supervisory system. The MON supervisory system receives the alert signal and generates an alert message which includes audio message data and destination data. The destination data indicates a destination of the audio message data. The audio message data may contain a voice announcement providing information or instructions regarding the emergency situation. The second communication network communicates the alert message from the MON supervisory system to the SRBN system.