Abstract: Provided are aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.

Abstract: The disclosure relates to a viewing optic. In one embodiment, the viewing optic has a direction sensor to capture the direction of wind. In one embodiment, the viewing optic has a ranging system to determine the distance to a target. In one embodiment, the viewing optic has a processor with a ballistics program that can use the distance and the wind direction to determine a ballistics trajectory. Further, the disclosure relates to methods for capturing wind direction.

Abstract: Vehicles and related systems and methods are provided for controlling a vehicle in an autonomous operating mode. One method involves determining a current value for a range of view associated with a sensing device onboard the vehicle, determining a target value for the range of view based at least in part on a speed of the vehicle, and in response to determining the current value is less than the target value, determining a dropback adjustment distance based at least in part on a difference between target value for the range of view and an estimated distance to a closest in path (CIP) vehicle ahead of the vehicle within a current lane of travel, determining a longitudinal trajectory for the vehicle based at least in part on the dropback adjustment distance, and autonomously operating one or more actuators onboard the vehicle in accordance with the longitudinal trajectory.

Abstract: The disclosure relates to a viewing optic. In one embodiment, the viewing optic has a direction sensor to capture the direction of wind. In one embodiment, the viewing optic has a ranging system to determine the distance to a target. In one embodiment, the viewing optic has a processor with a ballistics program that can use the distance and the wind direction to determine a ballistics trajectory. Further, the disclosure relates to methods for capturing wind direction.

Abstract: A viewing optic is disclosed. In one embodiment, the viewing optic is a rifle scope having a scope body, a movable optical element defining an optical axis connected to the scope body, a turret and a zero point adjustment subassembly. The turret includes a turret screw, a turret chassis subassembly and a turret cap. The turret screw defines a screw axis and is operably connected to the optical element for adjusting the optical axis in response to rotation of the screw. The turret cap at least partially overlaps the turret chassis subassembly. The zero point adjustment subassembly includes a zero cap connected to the turret screw and a locking mechanism. The locking mechanism releasably secures the zero cap and the turret. The zero point adjustment subassembly permits adjustment of the zero point without the use of tools.

Abstract: A system, apparatus, and method for event-based user matching. The apparatus includes a memory storing instructions a processor coupled with the memory. The processor is configured to execute the instructions to cause the apparatus to identify a set of events for a user, determine a list of prospective matches for the user attending one or more of the set of events for the user, and transmit the list of prospective matches for the user.

Abstract: A riflescope with a scope body has a movable optical element defining an optical axis connected to the scope body. The riflescope also has a turret having an outer knob and a turret screw defining a screw axis and operably connected to the optical element for changing the optical axis in response to rotation of the turret screw. The riflescope also includes a zero-adjustment assembly contained within the turret and operably interfacing with the turret screw. The zero-adjustment assembly comprises a zero-adjustment disc and a locking collar disposed around a downward facing central shaft of the zero-adjustment disc. The zero-adjustment disc is contained in an upper recess of the outer knob. The locking collar has a first position in which the zero-adjustment disc is freely rotatable about the turret screw and a second position in which free rotation of the zero-adjustment disc is prevented.

Abstract: Elongated fastener driving apparatuses are disclosed. The drivers are operable to quickly and accurately install fasteners from a standing position on, for example, a floor surface.

Abstract: A viewing optic is disclosed. In one embodiment, the viewing optic is a rifle scope having a scope body, a movable optical element defining an optical axis connected to the scope body, a turret and a zero point adjustment subassembly. The turret includes a turret screw, a turret chassis subassembly and a turret cap. The turret screw defines a screw axis and is operably connected to the optical element for adjusting the optical axis in response to rotation of the screw. The turret cap at least partially overlaps the turret chassis subassembly. The zero point adjustment subassembly includes a zero cap connected to the turret screw and a locking mechanism. The locking mechanism releasably secures the zero cap and the turret. The zero point adjustment subassembly permits adjustment of the zero point without the use of tools.

Abstract: The disclosure relates to target acquisition and related devices, and more particularly to viewing optics and associated equipment used to achieve shooting accuracy at, for example, close ranges, medium ranges and extreme ranges at stationary and moving targets.

Abstract: Disclosed are systems, devices and methods used in construction to secure one component, such as a header, to another component, such as a joist, while controlling spacing. Fasteners are used with a removable sleeve member having longitudinal ribs to secure the fastening assembly and prevent movement. An installation guide is provided that facilitates both flush and offset installation.

Abstract: A fastener includes a shank having a point at a first end and a second, head end. A first portion of a thread is formed with a first thread angle and a second portion of the thread is formed with a second thread angle. One or more knurls are provided in the shaft in the threaded or unthreaded regions of the fastener. The thread may be serrated or jagged over one or more portions of the fastener, including the area of the first thread angle.

Abstract: The disclosure relates to a viewing optic. In one embodiment, the viewing optic has a direction sensor to capture the direction of wind. In one embodiment, the viewing optic has a ranging system to determine the distance to a target. In one embodiment, the viewing optic has a processor with a ballistics program that can use the distance and the wind direction to determine a ballistics trajectory. Further, the disclosure relates to methods for capturing wind direction.

Abstract: The disclosure relates to a viewing optic. In one embodiment, the viewing optic has a direction sensor to capture the direction of wind. In one embodiment, the viewing optic has a ranging system to determine the distance to a target. In one embodiment, the viewing optic has a processor with a ballistics program that can use the distance and the wind direction to determine a ballistics trajectory. Further, the disclosure relates to methods for capturing wind direction.

Abstract: A viewing optic is disclosed. In one embodiment, the viewing optic is a rifle scope having a scope body, a movable optical element defining an optical axis connected to the scope body, a turret and a zero point adjustment subassembly. The turret includes a turret screw, a turret chassis subassembly and a turret cap. The turret screw defines a screw axis and is operably connected to the optical element for adjusting the optical axis in response to rotation of the screw. The turret cap at least partially overlaps the turret chassis subassembly. The zero point adjustment subassembly includes a zero cap connected to the turret screw and a locking mechanism. The locking mechanism releasably secures the zero cap and the turret. The zero point adjustment subassembly permits adjustment of the zero point without the use of tools.

Abstract: A system and method for processing X-ray fluorescence data in a hand-held X-ray Fluorescence (XRF) analyzer are provided. The X-ray fluorescence (XRF) analyzer includes a radiation source assembly including a first centerline axis and configured to direct an X-ray beam to impinge on a sample to be tested. The XRF analyzer also includes a radiation detector assembly including a second centerline axis configured to sense X-ray fluorescence (XRF) emitted from the sample in response to the X-ray beam. The XRF analyzer further includes a processor configured to determine a property of the sample to be tested from the emitted XRF, and a proximity sensor configured to continuously measure a distance between the XRF analyzer and the sample to be tested, the distance being at least one of displayed to a user and used by the processor to determine the property.

Abstract: A fastener includes a shank having a point at a first end and a second, head end. A head structure at the head end includes a top portion and having a cutting structure, the cutting structure comprising four planar walls, each wall engaging the shank at an angle, each wall adjoining an adjacent wall by a rounded edge.

Abstract: The disclosure relates to a viewing optic. In one embodiment, the viewing optic has a direction sensor to capture the direction of wind. In one embodiment, the viewing optic has a ranging system to determine the distance to a target. In one embodiment, the viewing optic has a processor with a ballistics program that can use the distance and the wind direction to determine a ballistics trajectory. Further, the disclosure relates to methods for capturing wind direction.