Abstract: A catheter apparatus for treatment of a human patient is described, the catheter apparatus having a central axis and comprising a shaping structure moveable between a delivery state having a first helical shape, and a deployed state having a second helical shape. The shaping structure is configured to have a reverse taper with a structural diameter that varies over the length of the shaping structure such that the structural diameter of the shaping structure at the proximal end is smaller than the structural diameter of the shaping structure at the distal end.

Abstract: A catheter apparatus for treatment of a human patient is described, the catheter apparatus having a central axis and comprising a shaping structure moveable between a delivery state having a first helical shape, and a deployed state having a second helical shape. The shaping structure is configured to have a reverse taper with a structural diameter that varies over the length of the shaping structure such that the structural diameter of the shaping structure at the proximal end is smaller than the structural diameter of the shaping structure at the distal end.

Abstract: A catheter apparatus for treatment of a human patient is described, the catheter apparatus having a central axis and comprising a shaping structure moveable between a delivery state having a first helical shape, and a deployed state having a second helical shape. The shaping structure is configured to have a reverse taper with a structural diameter that varies over the length of the shaping structure such that the structural diameter of the shaping structure at the proximal end is smaller than the structural diameter of the shaping structure at the distal end.

Abstract: A federated authentication service technology (10) for authenticating a subject (20) residing in a subject domain (12) on a network to a server application (38) residing in a server domain (18), wherein an authentication mechanism (32) residing in an authentication domain (16) affects the service provided by the server application (38). A client (22), which may be integrated non-human instances of the subject (20), authenticates the subject (20) and a protocol proxy (34) mediates with the authentication mechanism (32) to obtain a name assertion which the client can use to access the server application (38). When multiple authentication mechanisms (32) are available, an optional agent (24), mechanism resolution process (26) and mechanism repository (28), all residing in an agent domain (14), may be used to resolve to one suitable authentication mechanism (32).

Abstract: The present invention is directed to a process for the isolation of (R)-tofisopam with high enantiomeric purity and high overall yields from a mixture of tofisopam enantiomers by means of a non-steady state continuous chromatographic process.

Abstract: A federated authentication service technology (10) for authenticating a subject (20) residing in a subject domain (12) on a network to a server application (38) residing in a server domain (18), wherein an authentication mechanism (32) residing in an authentication domain (16) affects the service provided by the server application (38). A client (22), which may be integrated non-human instances of the subject (20), authenticates the subject (20) and a protocol proxy (34) mediates with the authentication mechanism (32) to obtain a name assertion which the client can use to access the server application (38). When multiple authentication mechanisms (32) are available, an optional agent (24), mechanism resolution process (26) and mechanism repository (28), all residing in an agent domain (14), may be used to resolve to one suitable authentication mechanism (32).

Abstract: A federated authentication service technology (10) for authenticating a subject (20) residing in a subject domain (12) on a network to a server application (38) residing in a server domain (18), wherein an authentication mechanism (32) residing in an authentication domain (16) affects the service provided by the server application (38). A client (22), which may be integrated non-human instances of the subject (20), authenticates the subject (20) and a protocol proxy (34) mediates with the authentication mechanism (32) to obtain a name assertion which the client can use to access the server application (38). When multiple authentication mechanisms (32) are available, an optional agent (24), mechanism resolution process (26) and mechanism repository (28), all residing in an agent domain (14), may be used to resolve to one suitable authentication mechanism (32).