Abstract: Methods and systems for manipulating drops in microfluidic channels are provided.

Abstract: A plastic injection molding system includes a mold having an interior surface and an exterior surface. The interior surface defines a mold cavity, which is configured in a shape of a part to be formed. A source of plastic, having a known heat deflection temperature, is injected into the mold cavity. At least one infrared heat source is disposed adjacent the mold. The at least one heat source is moveable between a first position disposed away from the interior surface of the mold and a second position where the at least one heat source is in communication with the mold cavity surface. A controller is in communication with the at least one heat source and is configured to heat the mold cavity surface to a predetermined temperature below the heat deflection temperature of the plastic resin.

Abstract: A plastic injection molding system includes a mold having an interior surface and an exterior surface. The interior surface defines a mold cavity, which is configured in a shape of a part to be formed. A source of plastic, having a known heat distortion temperature, is injected into the mold cavity. At least one infrared heat source is disposed adjacent the mold. The at least one heat source is moveable between a first position disposed away from the interior surface of the mold and a second position where the at least one heat source is in communication with the mold cavity surface. A controller is in communication with the at least one heat source and is configured to heat the mold cavity surface to a predetermined temperature below the heat distortion temperature of the plastic resin.

Abstract: The disclosure provides a railroad tie including a core, a first sleeve encapsulating the core and a second sleeve encapsulating the first sleeve. The first sleeve includes fingers running parallel to a long axis of the core along a top surface and fingers running perpendicular to a long axis of the tie along elongated sides of the first sleeve.

Abstract: A railroad tie comprises a core comprising wood or a wood product, and a first sleeve encapsulating the core, wherein the first sleeve comprises at least one of the group consisting of plastic, plastic-composite, or non-plastic polymers. A second sleeve may additionally encapsulate the first. In a preferred embodiment, the first sleeve is comprised primarily of poly ethylene terephthalate, and the second sleeve is comprised primarily of high density poly ethylene.

Abstract: A mounting for an all-in-one personal computer (10) that has a stand (12) for supporting the computer on a table or desk to enable the computer to be mounted on a wall or at the end of an articulated arm. A bracket (16) has a first wall (16A) that is disposed to confront a face of the stand surrounding the through-hole in the stand and that contains a through-hole (24) that registers with a through-hole (26) in the stand and a second wall (16B) that joins with the first wall and that contains a VESA compliant hole pattern that provides for attachment to a VESA compliant member. A hollow bolt (20) and a nut (22) coact with the registered through-holes to hold the first wall of the bracket fast on the stand.

Abstract: In some aspects, the invention provides a genetically tractable in situ non-human animal model for hepatocellular carcinoma. The model is useful, inter alia, in understanding the molecular mechanisms of liver cancer, in understanding the genetic alterations that lead to chemoresistance or poor prognosis, and in identifying and evaluating new therapies against hepatocellular carcinomas. The liver cancer model of this invention is made by altering hepatocytes to increase oncogene expression, to reduce tumor suppressor gene expression or both and by transplanting the resulting hepatocytes into a recipient non-human animal. The present invention also provides methods for identifying and validating tumor suppressor genes by screening pools of shRNAs that target genomic regions deleted in human cancers, such as human hepatocellular carcinomas.

Abstract: The invention provides methods for diagnosing cancers in humans by detecting DNA amplifications in chromosomal region 8p22, which encompasses the FGF-20 gene and the EFHA2 gene. Also provided are cancer treatment methods using inhibitors of FGF-20 and EFHA2. The invention also provides methods for promoting successful regeneration of liver function. These methods can be used therapeutically to improve liver function following transplantation in both recipient and donor subjects.

Abstract: A printed circuit laminate is provided comprising at least one conductor trace for carrying forward electrical signals in a first direction of signal propagation. The printed circuit laminate also comprises a mesh reference plane, spaced from the at least one conductor trace, for carrying return electrical signals in a second direction. The mesh reference plane defines a plurality of cells. Each cell of the plurality of cells includes at least one axis of repetition. The plurality of cells are configured so that all of the axes of repetition of each cell are different from the first direction of signal propagation. Furthermore, the frequency of cell repetition along the first direction of signal propagation is chosen to reduce differences in transmission line impedance between any two conductors on the same laminate or any two conductors on different laminates.

Abstract: A mounting for an all-in-one personal computer (10) that has a stand (12) for supporting the computer on a table or desk to enable the computer to be mounted on a wall or at the end of an articulated arm. A bracket (16) has a first wall (16A) that is disposed to confront a face of the stand surrounding the through-hole in the stand and that contains a through-hole (24) that registers with a through-hole (26) in the stand and a second wall (16B) that joins with the first wall and that contains a VESA compliant hole pattern that provides for attachment to a VESA compliant member. A hollow bolt (20) and a nut (22) coact with the registered through-holes to hold the first wall of the bracket fast on the stand.

Abstract: The present invention provides nucleic acid and protein sequences for a novel potassium channel protein, KCNB. The herein-disclosed sequences can be used for any of a number of purposes, including for the specific detection of KCNB, for the identification of molecules that associate with and/or modulate the activity of KCNB, to diagnose any of a number of conditions associated with KCNB or KCNB activity, or to modulate the number or activity of KCNB molecules in a mammal.

Abstract: The present invention provides nucleic acid and protein sequences for a novel potassium channel protein, KCNB. The herein-disclosed sequences can be used for any of a number of purposes, including for the specific detection of KCNB, for the identification of molecules that associate with and/or modulate the activity of KCNB, to diagnose any of a number of conditions associated with KCNB or KCNB activity, or to modulate the number or activity of KCNB molecules in a mammal.

Abstract: The invention provides methods for diagnosing cancers in humans by detecting DNA amplifications in chromosomal region 8p22, which encompasses the FGF-20 gene and the EFHA2 gene. Also provided are cancer treatment methods using inhibitors of FGF-20 and EFHA2. The invention also provides methods for promoting successful regeneration of liver function. These methods can be used therapeutically to improve liver function following transplantation in both recipient and donor subjects.

Abstract: A mechanism for mapping an anatomical characteristic of a patient includes a treatment bed having a top surface. A fiber Bragg grating channel is disposed along at least a portion of the treatment bed near the top surface and includes a fiber optic waveguide defining a plurality of spaced-apart Bragg-type gratings. A multi-wavelength light source generates a beam that is in optical communication with the fiber Bragg grating channel. A detector, in optical communication with the fiber Bragg grating channel, detects reflections of light from at least one of the Bragg-type gratings. A computer is programmed to calculate at least one anatomical characteristic based on a characteristic of at least one of the reflection of light.

Abstract: DNA is provided which encodes an enzyme having phytase activity isolated from Penicillium, Fusarium, Humicola and Emericella. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a suitable host organism, expression of the transformed DNA and the use of the expressed phytase protein in feed as a supplement.

Abstract: DNA is provided which encodes an enzyme having phytase activity isolated from Penicillium, Fusarium, Humicola and Emericella. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a suitable host organism, expression of the transformed DNA and the use of the expressed phytase protein in feed as a supplement.

Abstract: The invention relates to the field of biology. In particular, it relates to multi-epitope nucleic acid and peptide vaccines and methods of designing such vaccines to provide increased immunogenicity.

Abstract: The present invention provides CD4+ T-cell epitopes in E6, E7 and E2 proteins from various strains of human papillomavirus (HPV). In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high-risk HPV strains. In additional embodiments, the present invention provides means for the development of therapeutic vaccines against high-risk HPV types that prevent the development of benign and/or malignant tumors in infected individuals. The present invention further provides epitopes suitable for use in prophylactic and therapeutic vaccines.