Patents by Inventor Scott Quenton HARPER

Scott Quenton HARPER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant Virus Products and Methods for Inducing DUX4 Exon Skipping
    Publication number: 20190024083
    Abstract: The present invention relates to methods for shifting the splicing profile of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding U7-based small nuclear RNAs to induce DUX4 exon-skipping and the expression of shortened forms of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.
    Type: Application
    Filed: February 24, 2017
    Publication date: January 24, 2019
    Inventor: Scott Quenton Harper
  • RECOMBINANT VIRUS PRODUCTS AND METHODS FOR INHIBITION OF EXPRESSION OF DUX4
    Publication number: 20170029849
    Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.
    Type: Application
    Filed: October 17, 2016
    Publication date: February 2, 2017
    Inventors: Scott Quenton Harper, Jian Liu, Sara Coppens, Lindsay Wallace
  • RECOMBINANT VIRUS PRODUCTS AND METHODS FOR INHIBITION OF EXPRESSION OF MYOTILIN
    Publication number: 20160310548
    Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the myotilin gene. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of myotilin. The methods have application in the treatment of muscular dystrophies such as Limb Girdle Muscular Dystrophy Type 1A.
    Type: Application
    Filed: September 14, 2015
    Publication date: October 27, 2016
    Inventors: SCOTT QUENTON HARPER, JIAN LIU
  • Recombinant virus products and methods for inhibition of expression of DUX4
    Patent number: 9469851
    Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.
    Type: Grant
    Filed: July 24, 2012
    Date of Patent: October 18, 2016
    Assignee: NATIONWIDE CHILDREN'S HOSPITAL, INC.
    Inventors: Scott Quenton Harper, Jian Liu, Sara Garwick Coppens, Lindsay Wallace
  • Recombinant virus products and methods for inhibition of expression of myotilin
    Patent number: 9133482
    Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the myotilin gene. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of myotilin. The methods have application in the treatment of muscular dystrophies such as Limb Girdle Muscular Dystrophy Type 1A.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: September 15, 2015
    Assignee: NATIONWIDE CHILDREN'S HOSPITAL, INC.
    Inventors: Scott Quenton Harper, Jian Liu
  • Recombinant Virus Products and Methods for Inhibition of Expression of DUX4
    Publication number: 20140322169
    Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.
    Type: Application
    Filed: July 24, 2012
    Publication date: October 30, 2014
    Applicant: NATIONWIDE CHILDREN'S HOSPITAL, INC.
    Inventors: Scott Quenton Harper, Jian Liu, Sara Garwick, Lindsay Wallace
  • RECOMBINANT VIRUS PRODUCTS AND METHODS FOR INHIBITION OF EXPRESSION OF MYOTILIN
    Publication number: 20140045925
    Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the myotilin gene. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of myotilin. The methods have application in the treatment of muscular dystrophies such as Limb Girdle Muscular Dystrophy Type 1A.
    Type: Application
    Filed: October 21, 2013
    Publication date: February 13, 2014
    Applicant: Nationwide Children's Hospital, Inc.
    Inventors: Scott Quenton HARPER, Jian Liu