Patents by Inventor Scott Ralph
Scott Ralph has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11924756Abstract: A method includes determining, by a sensor node in communication with a communication network, an evacuation condition, retrieving by a decision node, occupancy information pertaining to an area, retrieving area data, and determining an evacuation route, at least in part using the evacuation condition, occupancy information, and area data, and communicating the determined evacuation route to area occupants.Type: GrantFiled: July 12, 2022Date of Patent: March 5, 2024Assignee: OneEvent Technologies, Inc.Inventors: Chris Snyder, Kurt Joseph Wedig, Daniel Ralph Parent, Anton Vermaak, Scott Holmstrom
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Patent number: 11279954Abstract: Provided is a construct comprising (i) a nucleotide sequence which encodes tyrosine hydroxylase (TH), (ii) a nucleotide sequence which encodes GTP-cyclohydrolase I (CH1) and (iii) a nucleotide sequence which encodes Aromatic Amino Acid Dopa Decarboxylase (AADC) wherein the nucleotide sequence encoding TH is linked to the nucleotide sequence encoding CH1 such that they encode a fusion protein TH-CH1. Also provided is a construct comprising (i) a nucleotide sequence which encodes tyrosine hydroxylase (TH), (ii) a nucleotide sequence which encodes GTP-cyclohydrolase I (CH1) and (iii) a nucleotide sequence which encodes Aromatic Amino Acid Dopa Decarboxylase (AADC) wherein the nucleotide sequence encoding AADC is linked to the nucleotide sequence encoding TH such that they encode a fusion protein AADC-TH or TH-AADC. Further provided is a viral vector comprising such nucleotide sequences and its use in the treatment and/or prevention of Parkinson's disease.Type: GrantFiled: June 26, 2019Date of Patent: March 22, 2022Assignee: Oxford BioMedica (UK) Ltd.Inventors: Kyriacos A. Mitrophanous, Scott Ralph, Hannah Stewart, Alan John Kingsman
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Publication number: 20200040361Abstract: Provided is a construct comprising (i) a nucleotide sequence which encodes tyrosine hydroxylase (TH), (ii) a nucleotide sequence which encodes GTP-cyclohydrolase I (CH1) and (iii) a nucleotide sequence which encodes Aromatic Amino Acid Dopa Decarboxylase (AADC) wherein the nucleotide sequence encoding TH is linked to the nucleotide sequence encoding CH1 such that they encode a fusion protein TH-CH1. Also provided is a construct comprising (i) a nucleotide sequence which encodes tyrosine hydroxylase (TH), (ii) a nucleotide sequence which encodes GTP-cyclohydrolase I (CH1) and (iii) a nucleotide sequence which encodes Aromatic Amino Acid Dopa Decarboxylase (AADC) wherein the nucleotide sequence encoding AADC is linked to the nucleotide sequence encoding TH such that they encode a fusion protein AADC-TH or TH-AADC. Further provided is a viral vector comprising such nucleotide sequences and its use in the treatment and/or prevention of Parkinson's disease.Type: ApplicationFiled: June 26, 2019Publication date: February 6, 2020Inventors: Kyriacos A. MITROPHANOUS, Scott RALPH, Hannah STEWART, Alan John KINGSMAN
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Patent number: 10400252Abstract: Provided is a construct comprising (i) a nucleotide sequence which encodes tyrosine hydroxylase (TH), (ii) a nucleotide sequence which encodes GTP-cyclohydrolase I (CH1) and (iii) a nucleotide sequence which encodes Aromatic Amino Acid Dopa Decarboxylase (AADC) wherein the nucleotide sequence encoding TH is linked to the nucleotide sequence encoding CH1 such that they encode a fusion protein TH-CH1. Also provided is a construct comprising (i) a nucleotide sequence which encodes tyrosine hydroxylase (TH), (ii) a nucleotide sequence which encodes GTP-cyclohydrolase I (CH1) and (iii) a nucleotide sequence which encodes Aromatic Amino Acid Dopa Decarboxylase (AADC) wherein the nucleotide sequence encoding AADC is linked to the nucleotide sequence encoding TH such that they encode a fusion protein AADC-TH or TH-AADC. Further provided is a viral vector comprising such nucleotide sequences and its use in the treatment and/or prevention of Parkinson's disease.Type: GrantFiled: October 26, 2012Date of Patent: September 3, 2019Assignee: Oxford BioMedica (UK) Ltd.Inventors: Kyriacos A. Mitrophanous, Scott Ralph, Hannah Stewart, Alan John Kingsman
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Publication number: 20180066425Abstract: A slide clip comprises a first plate and a second plate that are bent relative to each other and connected to each other at a juncture. In some embodiments, the first plate comprises a first internal flange positioned between a first lateral edge and a second lateral edge of the first plate. The first internal flange extends toward the second plate. The first plate further comprises a first slot positioned between the first internal flange and the first lateral edge. In other embodiments, the first plate further comprises a second internal flange and a second slot. The second slot may be positioned between the second internal flange and the second lateral edge. In some embodiments, an opening may be positioned between the first internal flange and the second internal flange.Type: ApplicationFiled: September 5, 2017Publication date: March 8, 2018Inventors: Gregory Scott Ralph, Gregg Allan Stahl, Nagaraj Eshwar, Thomas Jay Lawson
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Patent number: 9339512Abstract: Provided is a lentiviral vector for delivery to the brain for use in treating a neurological condition, wherein the lentiviral vector is delivered directly to the brain by delivering the lentiviral vector via six or fewer tracts per hemisphere, at a single deposit point per tract.Type: GrantFiled: May 14, 2013Date of Patent: May 17, 2016Assignee: Oxford BioMedica (UK) LimitedInventors: Peter Widdowson, Scott Ralph, Kyriacos A. Mitrophanous
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Publication number: 20130281975Abstract: Provided is a lentiviral vector for delivery to the brain for use in treating a neurological condition, wherein the lentiviral vector is delivered directly to the brain by delivering the lentiviral vector via six or fewer tracts per hemisphere, at a single deposit point per tract.Type: ApplicationFiled: May 14, 2013Publication date: October 24, 2013Inventors: Peter WIDDOWSON, Scott Ralph, Kyriacos A. Mitrophanous
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Publication number: 20120295960Abstract: Provided is an improved treatment for Parkinson's Disease where the efficacy of L-Dopa treatment is increased by including gene therapy in the treatment regimen. The combination therapy results in long-term improvements in response to L-Dopa and diminished side effects caused by L-Dopa.Type: ApplicationFiled: January 9, 2012Publication date: November 22, 2012Inventors: Stephane Palfi, Kyriacos A. Mitrophanous, Scott Ralph
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Publication number: 20110293571Abstract: Provided is a lentiviral vector for delivery to the brain for use in treating a neurological condition, wherein the lentiviral vector is delivered directly to the brain by delivering the lentiviral vector via six or fewer tracts per hemisphere, at a single deposit point per tract.Type: ApplicationFiled: May 27, 2011Publication date: December 1, 2011Applicant: Oxford BioMedica (UK) Ltd.Inventors: Peter WIDDOWSON, Scott Ralph, Kyriacos A. Mitrophanous
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Publication number: 20110269826Abstract: The present invention provides methods for: (i) treating and/or preventing Parkinson's disease in a subject without causing cognitive impairment by using dopamine replacement gene therapy to maintain or restore constant physiological dopaminergic tone in both the dorsal and ventral striatum of the subject; (ii) normalising neuronal electrical activity in basal ganglia and/or subthalamic nucleus in a Parkinson's disease subject; and (iii) treating and/or preventing dyskinesias associated with oral L-dopa administration in a Parkinson's disease subject by administration of a vector system for dopamine replacement gene therapy to the subject.Type: ApplicationFiled: November 11, 2009Publication date: November 3, 2011Applicant: OXFORD BIOMEDICA (UK) LIMITEDInventors: Susan M. Kingsman, Alan J. Kingsman, Scott Ralph, Kyriacos A. Mitrophanous, Stephane Palfi, Bechir Jarraya
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Patent number: D814905Type: GrantFiled: September 8, 2016Date of Patent: April 10, 2018Assignee: Clarkwestern Dietrich Building Systems LLCInventors: Gregory Scott Ralph, Gregg Allan Stahl, Nagaraj Eshwar, Thomas Jay Lawson
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Patent number: D815313Type: GrantFiled: September 8, 2016Date of Patent: April 10, 2018Assignee: Clarkwestern Dietrich Building Systems LLCInventors: Gregory Scott Ralph, Gregg Allan Stahl, Nagaraj Eshwar, Thomas Jay Lawson
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Patent number: D815314Type: GrantFiled: September 8, 2016Date of Patent: April 10, 2018Assignee: Clarkwestern Dietrich Building Systems LLCInventors: Gregory Scott Ralph, Gregg Allan Stahl, Nagaraj Eshwar, Thomas Jay Lawson
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Patent number: D815315Type: GrantFiled: September 8, 2016Date of Patent: April 10, 2018Assignee: Clarkwestern Dietrich Building Systems LLCInventors: Gregory Scott Ralph, Gregg Allan Stahl, Nagaraj Eshwar, Thomas Jay Lawson
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Patent number: D815316Type: GrantFiled: September 8, 2016Date of Patent: April 10, 2018Assignee: Clarkwestern Dietrich Building Systems LLCInventors: Gregory Scott Ralph, Gregg Allan Stahl, Nagaraj Eshwar, Thomas Jay Lawson
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Patent number: D817149Type: GrantFiled: September 8, 2016Date of Patent: May 8, 2018Assignee: Clarkwestern Dietrich Building Systems LLCInventors: Gregory Scott Ralph, Gregg Allan Stahl, Nagaraj Eshwar, Thomas Jay Lawson