Abstract: Embodiments of the invention are directed to a system, method, or computer program product for convenient, secure digital data archiving and utilization across multiple communication channels. The method includes extracting one or more data input fields from a form and generating one or more user prompts to be presented to a user in order to complete at least one of the one or more entries of the one or more data input fields. The method further includes causing the transmission of at least one of the one or more user prompts to the user and receiving a prompt response from the user. The method further includes displaying to the user a completed generated form in an appropriate channel format, and provides a process for secure e-signature and cross-stream utilization of user input.

Abstract: A method of forming a composite titanium body for use in forming spinal implant interbodies includes selecting a metal alloy body, carving out a top portion and a bottom portion from the metal alloy body, and bonding a porous material to the carved-out top and bottom portions. Multiple pieces may be cut from the composite titanium body, each having a front face formed of the metal alloy, top and bottom portions formed of the porous material, and with a medial portion of the metal alloy extending from the front face to the back. Methods and devices for spinal interbodies having locking mechanisms to prevent bone screw back-out are also described.

Abstract: Some embodiments include a system, comprising: at least one x-ray source, each x-ray source including: an electron source configured to generate an electron beam; and a target configured to receive the electron beam and convert the electron beam into an x-ray beam; and a collimator. A first edge of the collimator closest to the electron source is closer to the electron source than a central axis of the x-ray beam before entering the collimator; and a second edge of the collimator opposite to the first edge is at the central axis of the x-ray beam before entering the collimator or closer to the electron source than the central axis of the x-ray beam before entering the collimator.

Abstract: Some embodiments include an apparatus, comprising: a vacuum enclosure including an opening; a support structure disposed in the vacuum enclosure, the support structure comprising: a first portion attached to the vacuum enclosure at the opening; and a second portion extending within the vacuum enclosure; and a plurality of getters disposed on the second portion of the support structure.

Abstract: A method of forming a composite titanium body for use in forming spinal implant interbodies includes selecting a metal alloy body, carving out a top portion and a bottom portion from the metal alloy body, and bonding a porous material to the carved-out top and bottom portions. Multiple pieces may be cut from the composite titanium body, each having a front face formed of the metal alloy, top and bottom portions formed of the porous material, and with a medial portion of the metal alloy extending from the front face to the back. Methods and devices for spinal interbodies having locking mechanisms to prevent bone screw back-out are also described.

Abstract: Some embodiments include a system, comprising: a plurality of x-ray sources, each x-ray source including: an electron source configured to generate an electron beam; and a target configured to receive the electron beam and convert the electron beam into an x-ray beam; wherein: at first x-ray source of the x-ray sources is different from a second x-ray source of the x-ray sources; and the targets of the x-ray sources are part of a linear target.

Abstract: Some embodiments include an apparatus, comprising: a partition; a feedthrough penetrating the partition and hermetically sealed to the partition, the feedthrough having a major axis; a first wall extending from the partition in a first direction along the major axis; and a second wall extending from the partition in a second direction opposite to the first direction along the major axis, the second wall forming a connector interface with the feedthrough; wherein a ratio of a length of the first wall to a thickness of the first wall is greater than or equal to 3:1.

Abstract: A digit-mounted, spring-assisted device for launching a projectile in response to a launching motion of a finger by a user. The digit-mounted device may comprise a securing means for securing a launcher to the digit of the user. The securing means may comprise a strap, loop, or cinch. The digit-mounted device may further comprise a launch guide extending outwardly from a base member. A projectile may be mounted onto or into the launch guide. A spring may be mounted on the digit-mounted device which is placed under tension when the user prepares to make a launching motion with the digit. The projectile is launched in response to the user making a launching motion with the digit, using the thumb as a tensioning means. The spring is released from tension upon making a launching motion with the digit, adding to the force given to the projectile upon launch. The projectile may take a wide variety of forms.

Abstract: Disclosed herein are expandable interbodies with modular endplates. An expandable interbody has an outer column, an inner column threadedly coupled and translatable relative to the outer column along the longitudinal axis, and an expansion ring to adjust a body length of the expandable interbody. The expansion ring has a plurality of teeth, and the outer column has at least one arm for engaging a tooth of the plurality of teeth to lock the expansion ring. The inner column and/or outer column can include a connector for connection to a modular endplate that has a substantially hollow core. The modular endplate includes a plate with a set screw entrapped therein. The modular endplate has an aperture to receive the connector of the inner and/or outer column.

Abstract: Some embodiments include an x-ray device comprising: an access port configured to receive a cathode within an interior volume of an enclosure of the x-ray device; a first vacuum seal configured to seal a cover over the access port; and a second seal configured to seal the cover over the access port, the second seal maintained between the first vacuum seal and the interior volume of the enclosure during removal of the first vacuum seal.

Abstract: Some embodiments include an x-ray source, comprising: an anode; a field emitter configured to generate an electron beam; a first grid configured to control field emission from the field emitter; a second grid disposed between the first grid and the anode; a third grid disposed between the first grid and the anode; and a middle electrode disposed between the first grid and the anode wherein the second grid is either disposed between the first grid and middle electrode or between the middle electrode and the anode; wherein the third grid is a mesh grid.

Abstract: Embodiments include a system, comprising: a vacuum enclosure; an anode support structure penetrating the vacuum enclosure and including a plurality of first cooling passages; and an anode disposed within the vacuum enclosure, coupled to and supported by the anode support structure, and including: a target; and a plurality of second cooling passages; wherein: each of the second cooling passages is coupled to a corresponding first cooling passage; the anode is coupled to the anode support structure on a side of the anode different from a side of the anode including the target and different from axial ends of the anode on a major axis of the anode; and the anode is a linear anode.

Abstract: Some embodiments include an x-ray source, comprising: an anode; a field emitter configured to generate an electron beam; a first grid configured to control field emission from the field emitter; a second grid disposed between the first grid and the anode; and a middle electrode disposed between the first grid and the anode wherein the second grid is either disposed between the first grid and middle electrode or between the middle electrode and the anode.

Abstract: A system, comprising: a vacuum enclosure; an anode support structure penetrating the vacuum enclosure and including a plurality of first cooling passages; and an anode disposed within the vacuum enclosure, coupled to and supported by the anode support structure, and including: a target; and a plurality of second cooling passages; wherein: each of the second cooling passages is coupled to a corresponding first cooling passage; and the anode is coupled to the anode support structure on a side of the anode different from a side of the anode including the target and different from axial ends of the anode on a major axis of the anode.

Abstract: A digit-mounted, spring-assisted device for launching a projectile in response to a launching motion of a finger by a user. The digit-mounted device may comprise a securing means for securing a launcher to the digit of the user. The securing means may comprise a strap, loop, or cinch. The digit-mounted device may further comprise a launch guide extending outwardly from a base member. A projectile may be mounted onto or into the launch guide. A spring may be mounted on the digit-mounted device which is placed under tension when the user prepares to make a launching motion with the digit. The projectile is launched in response to the user making a launching motion with the digit, using the thumb as a tensioning means. The spring is released from tension upon making a launching motion with the digit, adding to the force given to the projectile upon launch. The projectile may take a wide variety of forms.

Abstract: The present disclosure provides technologies comprising a polynucleotide capable of expressing and/or inhibiting a KCNQ4 gene product.

Abstract: An intervertebral cage with an outer frame, an open inner core region and a porosity gradient within the outer frame is provided. The outer frame includes a posterior wall, an anterior wall, a pair of side walls extending between the posterior wall and the anterior wall and the porosity gradient may comprise at least one of: a decreasing average pore diameter in a direction from an outer surface to an inner surface of at least one of the pair of side walls; an increasing average pore diameter in a direction from an outer surface to an inner surface of at least one of the pair of side walls; a decreasing average pore diameter in a direction from an upper surface to a lower surface of at least one of the side walls; and an increasing average pore diameter in a direction from an upper surface to a lower surface of at least one of the side walls.

Abstract: An implantable medical device having a soft tissue interfacing surface comprises at least one soft actuatable capsule having a soft tissue interfacing deflectable membrane configured for cyclical deflection upon actuation of the capsule to modulate the biomechanics of the soft tissue interface during use. The actuatable capsule may comprise an actuation chamber containing a first fluid, a therapeutic chamber containing a second fluid, a deflectable membrane separating the actuation chamber and therapeutic chamber, and an actuation conduit in fluidic communication with the actuation chamber for pneumatic actuation of the actuation chamber. The therapeutic chamber comprises the soft tissue interfacing deflectable membrane which is configured to cyclically deflect during actuation of the capsule and modulate the biomechanics of the soft tissue interface by altering one or more of strain, fluid flow and cellular activity in peri-implant tissue at the soft tissue interface.

Abstract: This invention relates to oral care compositions comprising an effective amount of a basic amino acid in free or salt form, together with an antibacterial agent, and to methods of using and of making such compositions.