Abstract: Embodiments described herein are directed to methods for treating moderate to severe plaque psoriasis, atopic dermatitis, or radiation dermatitis in a subject comprising administering about 1.0% tapinarof in a topical composition to the affected areas of the subject once a day for an initial period of time until the plaque psoriasis, atopic dermatitis, or radiation dermatitis is clear at which time the administration is stopped, and reassessing the subject from about 3 months to about 12 months after administration is stopped to determine if further treatment is required. Also described is the remittive effect observed after once daily administration of 1% tapinarof cream.

Abstract: Embodiments described herein are directed to methods for treating moderate to severe plaque psoriasis, atopic dermatitis, or radiation dermatitis in a subject comprising administering about 1.0% tapinarof in a topical composition to the affected areas of the subject once a day for an initial period of time until the plaque psoriasis, atopic dermatitis, or radiation dermatitis is clear at which time the administration is stopped, and reassessing the subject from about 3 months to about 12 months after administration is stopped to determine if further treatment is required. Also described is the remittive effect observed after once daily administration of 1% tapinarof cream.

Abstract: Embodiments described herein are directed to topical compositions for administering cerdulatinib or a pharmaceutically acceptable salt, hydrate or solvate thereof. Embodiments described herein are also directed to methods for preparing the topical compositions. The disclosed compositions are suitable for the treatment of dermatologic conditions such as atopic dermatitis, cutaneous lupus, lichen planus, cutaneous graft versus host disease, contact dermatitis, psoriasis, rosacea, scleroderma, morphea and dermatomyositis.

Abstract: Embodiments described herein relate to topical pharmaceutical compositions comprising tapinarof, wherein the topical pharmaceutical composition is formulated as an aqueous gel, an anhydrous gel, an ointment, or a foam. Embodiments also relate to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.

Abstract: An item of outerwear includes an outer layer that is light weight, water resistant, and wind resistant. An inner layer has a plurality of apertures therethrough connecting an interstitial space between the outer layer and the inner layer with a space interior to the inner layer. A pocket houses a heat pack. A portion of the plurality of apertures permits airflow to and from the heat pack.

Abstract: A heated U-shaped travel neck pillow includes two leg portions. A base therebetween the two leg portions forms a U-shaped pillow body to receive and support a neck of a user. The heated U-shaped travel neck pillow also includes an inner radial portion of the U-shaped pillow body. In use, the inner radial portion is adjacent to the neck of the user. At least one pocket or pouch is formed on the inner radial portion of the U-shaped pillow body. Each of the at least one pocket houses a heat pack to provide a sustained, targeted, and controlled heat transfer to the user and to create a built-in heat zone on the inner radial portion of the heated U-shaped travel neck pillow.

Abstract: Embodiments are directed to an apparatus incorporating a smart phone and a celestial viewing device. A mounting device includes a bracket that is capable of holding a smart phone on a telescope or a pair of binoculars. This serves to support a user in viewing celestial objects in the sky, when the smart phone is running an application that assists the user in locating the celestial objects. The apparatus advantageously provides for finding stars, planets, constellations, satellites, and the like. The apparatus allows for the user to manipulate the celestial viewing device without being concerned about or inconvenienced by the placement or handling of the smart phone. Additionally, the apparatus positions the smart phone in an orientation necessary to synchronize information shown on the smart phone with the field of view of the celestial viewing device, greatly improving the user's ability to locate and view desired celestial objects.

Abstract: Heat packs are incorporated into various travel and comfort items, such as pillows, blankets, and the like, in a designated pocket and/or pouch within the items to provide a user with soothing, targeted, and controlled heat in a consistent, convenient, and comfortable application. A disposable heat pack may comprise a soft, lightweight, air-permeable pouch. One side of the heat pack is air-permeable to optimally direct the targeted heat to a user. The contents of the heat pack may include a mixture of iron powder, sawdust, activated carbon, salt, water, cellulose, and vermiculite. The pocket into which the heat pack is inserted is comprised of a spandex material or the like that is lightweight, permeable, breathable, flexible, and stretchable, providing superior contact while allowing for an optimal amount of heat to permeate from the pocket to the user.

Abstract: A method of treating a blistering disorder, which includes administering to a target tissue in a subject in need thereof an effective amount of a composition that inhibits activation of the HSP27 phosphorylation pathway.

Abstract: A method of treating a blistering disorder, which includes administering to a target tissue in a subject in need thereof an effective amount of a composition that inhibits activation of the HSP27 phosphorylation pathway.

Abstract: An electronic bar tool is disclosed that is capable of displaying titles and recipes for a plurality of mixed drinks. The apparatus comprises a handle having a display device and a measuring device for measuring a volume of liquid. The display displays the drink ingredients and the necessary volumes and may also indicate to a user the type of glass the drink is to be served in, whether the drink should be shaken or stirred, and whether the drink should be served with or without ice. The drink titles and recipes may be stored in a memory that may be changed through a communications port.

Abstract: An electronic wine thermometer comprises a housing having a temperature probe extending from the housing. A display panel is associated with the housing and interactive with operational circuitry contained within the housing. A heat sensor is located in the probe, and is in electronic communication with the operational circuitry completing the device is a cork extractor mounted on the housing.

Abstract: A drinking container cup, such as for coffee, tea soup or the like, having an interior and an exterior surface, said container having an integrated powered stirring device extending from the interior surface of the bottom section of the housing and driven by a small battery powered motor located in the bottom section of the housing. The bottom section and integrated stirring device are fitted with inside thread for screwing to the container and may be removed for separate cleaning or simply left in place, adding soap and turning on the stirring device. A removable lid which mechanically engages the top of the container is also provided.