Publication number: 20260034119
Abstract: Disclosed are compounds having the structure: wherein Z1 is NR4, O, or S; Z2 is CR7 or N; n is 1 to 5; R1 is —H, halogen, —O-alkyl, or together with R2 forms —O—CH2—O—; R2 is —H, —OH, —O-alkyl, —O-alkyl-aryl, —S-alkyl, —S-alkyl-aryl, or together with R1 or R3 forms —O—CH2—O—; R3 is —H, —O-alkyl or together with R2 forms —O—CH2—O—; R4 is H or alkyl; R5 and R6 are each independently H, alkyl, alkenyl, alkynyl or NR5R6 together form a substituted or unsubstituted heterocycle, wherein the heterocycle may be monocyclic or bicyclic, R7 is H or alkyl; wherein R1 is F, when R2 is —O-(n-propyl) or when at least one of R5 or R6 is H, and wherein the compound is other than a compound where Z1 is NR4 and R1, R2, R3, and R8 are H; n is 2, R1 is halogen, R2 is —OCH3, R3 is —H, R4 is —H, and R5 and R6 are both methyl; n is 2, R1 is —F, R2 is —OCH3, R3 is —H, R4 is —H, and NR5R6 together are —N-pyrrolidine; n is 2, R1 and R2 together forms —O—CH2—O—, R3 is —H, R4 is —H, and R5 and R6 are both methyl; and n is 2, R1
Type:
Application
Filed:
August 8, 2025
Publication date:
February 5, 2026
Applicants:
The Trustees of Columbia University in the City of New York, ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Inventors:
David LANKRI, Dalibor SAMES, Inis SERRANO, Michael CUNINGHAM, Audrey WARREN, Daniel WACKER, Lyonna PARISE, Scott RUSSO