Abstract: Pharmaceutical compounds, their methods of manufacture, and methods of treatment of mammals with pharmaceutical compounds are provided.

Abstract: A system for generating textual instructions for manufacturers from hybrid textual and image data includes a manufacturing instruction generator that may generate a language processing module from a first training set including at least a training annotated file describing at least a first product to manufacture, the at least an annotated file containing one or more textual data, and at least an instruction set containing one or more manufacturing instructions to manufacture the at least a first product. Manufacturing instruction generator may use the language processing to generate textual instructions for manufacturers from at least an annotated file and may initiate manufacture using the generated manufacturing instructions.

Abstract: Pharmaceutical compounds, their methods of manufacture, and methods of treatment of mammals with pharmaceutical compounds are provided.

Abstract: This disclosure relates to low molecular weight substituted imidazoles that inhibit the TGF-b signaling pathway. More specifically, this disclosure relates to methods of using said imidazoles for the treatment of diseases related to the TGF-b signaling pathways including, but not limited to, atherosclerosis, Marfan syndrome, Loeys-Dietz syndrome, obesity, diabetes, multiple sclerosis, keratoconus, idiopathic pulmonary fibrosis, Alzheimer's Disease, chronic kidney disease, and scleroderma.

Abstract: Pharmaceutical compounds, their methods of manufacture, and methods of treatment of mammals with pharmaceutical compounds are provided.

Abstract: Pharmaceutical compounds, their methods of manufacture, and methods of treatment of mammals with pharmaceutical compounds are provided.

Abstract: A system for generating textual instructions for manufacturers from hybrid textual and image data includes a manufacturing instruction generator that may generate a language processing module from a first training set including at least a training annotated file describing at least a first product to manufacture, the at least an annotated file containing one or more textual data, and at least an instruction set containing one or more manufacturing instructions to manufacture the at least a first product. Manufacturing instruction generator may use the language processing to generate textual instructions for manufacturers from at least an annotated file and may initiate manufacture using the generated manufacturing instructions.

Abstract: An apparatus may receive data. The data may include first data and second data. The first data may be received from a set of sensor devices located within one or more dispensing devices. The second data may be received from one or more devices located external to the one or more dispensing devices. The apparatus may process the data to generate a model. The apparatus may receive sensor data. The apparatus may determine a response action associated with the particular dispensing device based on the sensor data and the model. The apparatus may provide information associated with causing the response action to be implemented.

Abstract: The present invention relates to novel methods of using 2-{4-[(4-{[1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]oxy}pyridin-2-yl)amino]pyridin-2-yl}propan-2-ol or a pharmaceutically acceptable salt thereof to treat physiological conditions such as cancer.

Abstract: A device may obtain sensor data regarding the vending device. The device may transmit the sensor data via a network connection for processing by a server. The server may store a data model. The server may be associated with identifying a response action associated with altering a configuration of the vending device. The device may receive information identifying the response action based on transmitting the sensor data via the network connection. The device may cause the response action to be performed based on receiving the information identifying the response action. The response action may be associated with altering a status of a component of the vending device. The device may provide information associated with identifying the status of the component.

Abstract: A system may include a client device. The client device may receive, from a set of vending devices and via a network connecting the set of vending devices with the client device, sensor data relating to a status of the set of vending devices. The client device may generate a user interface associated with providing information identifying the status of the set of vending devices. The client device may provide, for display, the user interface based on generating the user interface. The client device may detect, based on providing the user interface, a selection of an adjustment that is to be performed for a particular vending device of the set of vending devices. The client device may transmit, via the network, an instruction to the particular vending device to cause the adjustment to be performed for the particular vending device.

Abstract: An apparatus may receive data. The data may include first data and second data. The first data may be received from a set of sensor devices located within one or more dispensing devices. The second data may be received from one or more devices located external to the one or more dispensing devices. The apparatus may process the data to generate a model. The apparatus may receive sensor data. The apparatus may determine a response action associated with the particular dispensing device based on the sensor data and the model. The apparatus may provide information associated with causing the response action to be implemented.

Abstract: A device may obtain sensor data regarding the vending device. The device may transmit the sensor data via a network connection for processing by a server. The server may store a data model. The server may be associated with identifying a response action associated with altering a configuration of the vending device. The device may receive information identifying the response action based on transmitting the sensor data via the network connection. The device may cause the response action to be performed based on receiving the information identifying the response action. The response action may be associated with altering a status of a component of the vending device. The device may provide information associated with identifying the status of the component.

Abstract: A system may include a client device. The client device may receive, from a set of vending devices and via a network connecting the set of vending devices with the client device, sensor data relating to a status of the set of vending devices. The client device may generate a user interface associated with providing information identifying the status of the set of vending devices. The client device may provide, for display, the user interface based on generating the user interface. The client device may detect, based on providing the user interface, a selection of an adjustment that is to be performed for a particular vending device of the set of vending devices. The client device may transmit, via the network, an instruction to the particular vending device to cause the adjustment to be performed for the particular vending device.

Abstract: The present invention relates to novel aminopyridyloxypyrazole compounds that inhibit the activity of transforming growth factor beta receptor 1 (TGF?R1), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, preferably colon cancer, melanoma, hepatocellular carcinoma, renal cancer, glioblastoma, pancreatic cancer, myelodysplastic syndrome, lung cancer, and gastric cancer, and/or fibrosis, preferably liver fibrosis and chronic kidney disease.

Abstract: The present invention relates to novel aminopyridyloxypyrazole compounds that inhibit the activity of transforming growth factor beta receptor 1 (TGF?R1), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, preferably colon cancer, melanoma, hepatocellular carcinoma, renal cancer, glioblastoma, pancreatic cancer, myelodysplastic syndrome, lung cancer, and gastric cancer, and/or fibrosis, preferably liver fibrosis and chronic kidney disease.

Abstract: An apparatus and a process for wellbore characterization are disclosed, including: separating, in a separation vessel, drilling mud from gas produced during drilling of a wellbore; transporting the separated produced gas from the separation vessel to a downstream process; and measuring at least one of a temperature, a pressure, a mass flow rate, and a volumetric flow rate of the separated produced gas during transport using one or more sensors. Properties of the gas separated from the mud may be used to determine characteristics of a wellbore.

Abstract: Apparatus for sanitizing a water stream comprises a first electrolysis cell which produces ions with algaecidal and bactericidal properties and a second electrolysis cell which oxidizes water to produce hydrogen peroxide. The first cell has copper electrodes and the second cell has titanium electrodes and the polarity of the electrodes is periodically reversed at a frequency of from three to nine minutes. Air is introduced into the stream prior to entering the cells.

Abstract: The present invention provides AKT inhibitors of the formula: Formula I The present invention also provides pharmaceutical compositions comprising compounds of Formula I, uses of compounds of Formula I and method of using compounds of Formula I.

Abstract: A failure protection apparatus including an air source providing air having an air pressure, a first valve in fluid communication with the air source permitting a control fluid to flow to a pressure control assembly when the air pressure is at least a minimum pressure and preventing flow of the control fluid to the assembly when the air pressure is below a minimum pressure, the assembly containing control fluid at a predetermined pressure that is maintained when the air pressure is below the minimum pressure, a second valve in communication with the air source permitting communication of air between an inlet and an outlet when the air pressure is below the minimum pressure, a third valve in communication with the air source, a pressure container in communication with the third valve outlet and having an outlet that feeds air to the second valve to actuate a warning device attached thereto.