Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

Abstract: The present invention provides novel compositions, methods of treatment and methods of manufacture of large scale, commercially viable ibuprofen and acetaminophen tablets. The unique characteristics and synergistic effects resulting from the disclosed compositions, methods of treatment and methods of manufacture demonstrate a product with optimal analgesia, anti-pyresis, safety profiles and large-scale manufacturability. The inventions described herein surprisingly show the unique composition and method of manufacturing for a large-scale commercial batch of a novel ibuprofen and acetaminophen tablet.

Abstract: A non-invasive thermal dispersion flow meter with chronometric monitor for fluid leak detection includes a heater, an ambient temperature sensor and a flow rate sensor which are configured to sense the temperature of a fluid in a conduit, and then monitor the flow of that fluid through the conduit. Based upon the ambient temperature sensor readings, the flow rate sensor and heater may be adjusted to optimize the operation of the system to detect leaks. Based on the sensor readings, the flow may be adjusted to prevent damage and leaks by relieving the system of excess pressure. Geographic location, occupancy sensors and occupant identifiers are used to control the system to facilitate operation and minimize leak damage when occupants are away.

Abstract: Vehicle assemblies are provided that include movable door assemblies. Examples of vehicle assemblies with movable door assemblies include charge port housing assemblies and fuel fill housing assemblies. An exemplary vehicle assembly may include an override retainer. The override retainer may include a flexible flap or clip that is configured to deflect or otherwise distort to release a latching assembly from the door assembly when a manual override force is applied to the door assembly.

Abstract: Vehicle assemblies are provided that include movable door assemblies. Examples of vehicle assemblies with movable door assemblies include charge port housing assemblies and fuel fill housing assemblies. An exemplary vehicle assembly may include an override retainer. The override retainer may include a flexible flap or clip that is configured to deflect or otherwise distort to release a latching assembly from the door assembly when a manual override force is applied to the door assembly.

Abstract: A non-invasive thermal dispersion flow meter with chronometric monitor for fluid leak detection includes a heater, an ambient temperature sensor and a flow rate sensor which are configured to sense the temperature of a fluid in a conduit, and then monitor the flow of that fluid through the conduit. Based upon the ambient temperature sensor readings, the flow rate sensor and heater may be adjusted to optimize the operation of the system to detect leaks. Based on the sensor readings, the flow may be adjusted to prevent damage and leaks by relieving the system of excess pressure. Geographic location, occupancy sensors and occupant identifiers are used to control the system to facilitate operation and minimize leak damage when occupants are away.

Abstract: Methods, systems, and computer storage media for providing observation stream data of security incidents using an observation stream engine in a security management system. An observation stream framework supports continuously generating and presenting observation stream data that facilitates developing a working hypothesis of an active security incident. The observation stream framework can also include observation stream query-types that can be selected for running queries against a plurality of security data sources. In operation, an observation stream query is accessed. The observation stream query is a user-generated observation stream query associated with an observation stream query-type. The observation stream query-type comprises parameters for querying a plurality of security data sources and dynamic tracking of a security incident. The observation stream query is executed and observation stream data is generated.

Abstract: Provided herein are disinfecting compositions of a biocidal agent with a polyglycerol ester having a synergistic effect which allow for a reduction in the amount of the biocidal agent necessary to be an effective disinfecting composition.

Abstract: The present disclosure relates to antimicrobial skin disinfectant compositions such as hand disinfectant soaps, comprising one or more quaternary ammonium compounds, one or more surfactants and an aromatic alcohol, achieving anti-bacterial and fungicidal or yeasticidal efficacy in short contact times.

Abstract: Provided herein are preservative composition of a preservative agent with a polyglycerol ester having a synergistic effect which allow for a reduction in the amount of the preservative agent necessary to be an effective preservative in an end-use formulation.

Abstract: Provided herein are preservative compositions containing a preservative agent with an alkylene glycol ester. Also provided are method for increasing the efficacy of preservative agents and methods for reducing the minimum amount of preservative agent needed for effective preservation activity in end-use formulations.

Abstract: A non-invasive thermal dispersion flow meter with chronometric monitor for fluid leak detection includes a heater, an ambient temperature sensor and a flow rate sensor which are configured to sense the temperature of a fluid in a conduit, and then monitor the flow of that fluid through the conduit. Based upon the ambient temperature sensor readings, the flow rate sensor and heater may be adjusted to optimize the operation of the system to detect leaks. Based on the sensor readings, the flow may be adjusted to prevent damage and leaks by relieving the system of excess pressure. Geographic location, occupancy sensors and occupant identifiers are used to control the system to facilitate operation and minimize leak damage when occupants are away.

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

Abstract: This disclosure is directed to vehicle assemblies that include movable door assemblies. Examples of vehicle assemblies with movable door assemblies include charge port housing assemblies and fuel fill housing assemblies. An exemplary vehicle assembly may include an override retainer. The override retainer may include a flexible flap or clip that is configured to deflect or otherwise distort to release a latching assembly from the door assembly when a manual override force is applied to the door assembly.

Abstract: An acidic aqueous shampoo composition, which comprises: (I) a cleansing surfactant selected from the group consisting of anionic surfactant, zwitterionic or amphoteric surfactant and nonionic surfactant; (II) an emulsified silicone, (III) an anti-settling, thickening polymer, wherein the anti-settling, thickening polymer, comprises: (a) 40 to 74.5 wt % of structural units of C1-4 alkyl acrylate; (b) 20 to 50 wt % of structural units of methacrylic acid; (c) 0.

Abstract: An aqueous anti-dandruff shampoo composition which comprises: (I) a cleansing surfactant selected from the group consisting of anionic surfactant, zwitterionic or amphoteric surfactant and nonionic surfactant; (II) suspended particles of an anti-dandruff agent, (III) an anti-settling, thickening polymer, wherein the anti-settling, thickening polymer, comprises: (a) 40 to 74.5 wt % of structural units of C1-4 alkyl acrylate; (b) 20 to 50 wt % of structural units of methacrylic acid; (c) 0.

Abstract: This disclosure relates to a fuel or charging port door assembly of a motor vehicle. In particular, this disclosure relates to a fuel or charging port door assembly configured to permit a door to open when an override force is applied using an assist tool, for example. An example vehicle includes a door configured to move relative to a body of the vehicle between open and closed positions. The door is a fuel door or a charging port door. The vehicle also includes a lock assembly including a base and a tip. The base is configured to hold the tip during normal operating conditions, and the base and tip are configured to separate upon application of an override force to the door.

Abstract: Disclosed herein is a system for facilitating fast and intuitive investigations of security incidents by responding to physical gestures performed by security analysts within a virtual scene. A query triggers an alert for detecting security incidents that occur with respect to computing resources. Following the alert, the security analyst dons a Near-Eye-Display (NED) device and is presented with a virtual scene having control elements representing various data sets and/or data analysis operations relevant to a security incident. The security analyst investigates the security incident by performing hand motions to “grab-and-drag” control elements representing data sets. The security analyst may also perform hand motions to “tap on” control elements that represents a data analysis operation. Responsive to the hand motions, the system performs data analysis operations and displays a result within the virtual scene.

Abstract: A composition comprising: (i) 0.01 to 10 wt % of a linear, cationic conditioning surfactant; (ii) 0.1 to 10 wt % of a linear fatty material; (iii) a particulate benefit agent selected from conditioning actives, scalp actives, encapsulated fragrance, emulsified fragrance, and mixtures thereof; (iv) 0.

Abstract: Disclosed herein is a system for facilitating fast and intuitive investigations of security incidents by responding to physical gestures performed by security analysts within a virtual scene. A query triggers an alert for detecting security incidents that occur with respect to computing resources. Following the alert, the security analyst dons a Near-Eye-Display (NED) device and is presented with a virtual scene having control elements representing various data sets and/or data analysis operations relevant to a security incident. The security analyst investigates the security incident by performing hand motions to “grab-and-drag” control elements representing data sets. The security analyst may also perform hand motions to “tap on” control elements that represents a data analysis operation. Responsive to the hand motions, the system performs data analysis operations and displays a result within the virtual scene.