Abstract: The disclosure provides crystalline forms for certain synthetic intermediates for making belzutifan, a HIF-2? inhibitor, useful for the treatment of cancer. The disclosure also provides processes for isolating the crystalline forms.

Abstract: The disclosure provides crystalline forms for certain synthetic intermediates for making belzutifan, a HIF-2? inhibitor, useful for the treatment of cancer. The disclosure also provides processes for isolating the crystalline forms.

Abstract: The invention is directed to novel anhydrous crystalline butenedioate salt form 1 of Compound I, which is a modulator of muscarinic M1 receptors. The novel crystalline forms of compound I are useful in the treatment or prevention of Alzheimer's disease and other disorders and diseases in which muscarinic M1 receptors are involved. The invention is further directed to pharmaceutical compositions comprising the novel crystalline forms of Compound I.

Abstract: Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

Abstract: Embodiments provide an inkjet cartridge refilling system. The system may include a drill station configured to drill at least one refilling hole in an inkjet printer cartridge. The system may include an evacuation station configured to remove excess ink from the inkjet printer cartridge. In some embodiments, the excess ink is removed via a vacuum source. The system may also include a filling station configured to provide any of a plurality of inks into the cartridge. Some embodiments provide the ink to the inkjet cartridge via a hole drilled in the cartridge. Other embodiments provide the ink via inkjet nozzles of the inkjet printer cartridge. The system may also include a test station configured to test the refilled cartridge to determine whether it is functioning properly after being filled with ink.

Abstract: The present invention relates to novel Pseudopolymorphs of Compound A, compositions comprising at least one Pseudopolymorph of Compound A, and methods of using the Pseudopolymorphs of Compound A for preparing compositions useful for treating or preventing HCV infection in a patient, wherein Compound A has the structure.

Abstract: The present invention relates to different forms of a HCV inhibitory compound.

Abstract: The present invention relates to different forms of a HCV inhibitory compound.

Abstract: In some aspects, the disclosure relates to composite fabric assembly comprising a fabric substrate including a surface and a layer adhered to or impregnated into the surface of the fabric substrate, the layer including polymer resin particles, wherein polymer resin particles are configured to adsorb at least one of an organic compound, inorganic compound, or chemicals.

Abstract: In some examples, a kit comprising a garment to be worn by a user; a fall arrest safety harness integrated into the garment; and a suspension relief strap configured to be coupled to the fall arrest safety harness, and wherein the fall arrest safety harness is integrated into the garment such that, when the garment is worn by the user, the fall arrest safety harness is worn by the user in a manner that arrests a fall by the user when the fall arrest safety harness is anchored.

Abstract: Embodiments provide an inkjet cartridge refilling system. The system may include a drill station configured to drill at least one refilling hole in an inkjet printer cartridge. The system may include an evacuation station configured to remove excess ink from the inkjet printer cartridge. In some embodiments, the excess ink is removed via a vacuum source. The system may also include a filling station configured to provide any of a plurality of inks into the cartridge. Some embodiments provide the ink to the inkjet cartridge via a hole drilled in the cartridge. Other embodiments provide the ink via inkjet nozzles of the inkjet printer cartridge. The system may also include a test station configured to test the refilled cartridge to determine whether it is functioning properly after being filled with ink.

Abstract: Embodiments provide an inkjet cartridge refilling system. The system may include a drill station configured to drill at least one refilling hole in an inkjet printer cartridge. The system may include an evacuation station configured to remove excess ink from the inkjet printer cartridge. In some embodiments, the excess ink is removed via a vacuum source. The system may also include a filling station configured to provide any of a plurality of inks into the cartridge. Some embodiments provide the ink to the inkjet cartridge via a hole drilled in the cartridge. Other embodiments provide the ink via inkjet nozzles of the inkjet printer cartridge. The system may also include a test station configured to test the refilled cartridge to determine whether it is functioning properly after being filled with ink.

Abstract: Embodiments provide an inkjet cartridge refilling system. The system may include a drill station configured to drill at least one refilling hole in an inkjet printer cartridge. The system may include an evacuation station configured to remove excess ink from the inkjet printer cartridge. In some embodiments, the excess ink is removed via a vacuum source. The system may also include a filling station configured to provide any of a plurality of inks into the cartridge. Some embodiments provide the ink to the inkjet cartridge via a hole drilled in the cartridge. Other embodiments provide the ink via inkjet nozzles of the inkjet printer cartridge. The system may also include a test station configured to test the refilled cartridge to determine whether it is functioning properly after being filled with ink.

Abstract: Embodiments provide an inkjet cartridge refilling system. The system may include a drill station configured to drill at least one refilling hole in an inkjet printer cartridge. The system may include an evacuation station configured to remove excess ink from the inkjet printer cartridge. In some embodiments, the excess ink is removed via a vacuum source. The system may also include a filling station configured to provide any of a plurality of inks into the cartridge. Some embodiments provide the ink to the inkjet cartridge via a hole drilled in the cartridge. Other embodiments provide the ink via inkjet nozzles of the inkjet printer cartridge. The system may also include a test station configured to test the refilled cartridge to determine whether it is functioning properly after being filled with ink.

Abstract: Embodiments provide a system and method for cleaning inkjet cartridges. The system includes a fixture configured to mount an inkjet cartridge where a printhead of the inkjet cartridge is mounted to a cleaning plate. The cleaning plate includes one or more orifices connected to a vacuum source and one or more orifices connected to a wash solution source. The vacuum source can be used to extract ink from within the cartridge through nozzles in the printhead. The wash solution source can supply a pressurized wash solution through the nozzles of the printhead. The vacuum source can also be use to extract the wash solution from within the cartridge through the nozzles.

Abstract: A service registry that supports updating and sharing of profile data with partners. The registry allows organizations such as libraries and consortia to manage and share data that define their organizations (e.g., institution type, location, main and branch institutions, URLs for electronic services, circulation statistics, and population served). Organizations share a RSS-enabled obfuscated link with their partners that enables the partners to access a page with the latest institutional profile, and to be notified when it is updated. The obfuscation of the RSS feed provides a notification while keeping the data private. Every time a user creates an institutional profile, an equivalent RSS-enabled page is generated that can be reached through a RSS feed that has an obfuscated link name. The user shares this link with the institution's partners and others that have a need to know the information and to access details about the institution and its services.

Abstract: The present invention is directed to a practical process for the preparation of an enamide (II) by palladium catalyzed coupling of a primary amide (IV) with a compound of structural formula (III), as shown below: As well as to crystalline forms of a compound produced by this process, in particular, an anhydrous crystal form, Form B, and crystalline solvates falling into three patterns, Type 1, Type 2, and Type 3, and crystalline intermediate compounds produced in the process. Still further, the present invention relates to the stereoselective reduction of the tetrasubstituted enamide (II) to the corresponding amide (I).

Abstract: The present invention is directed to a practical process for the preparation of an enamide (II) by palladium catalyzed coupling of a primary amide (IV) with a compound of structural formula (III), as shown below: As well as to crystalline forms of a compound produced by this process, in particular, an anhydrous crystal form, Form B, and crystalline solvates falling into three patterns, Type 1, Type 2, and Type 3, and crystalline intermediate compounds produced in the process. Still further, the present invention relates to the stereoselective reduction of the tetrasubstituted enamide (II) to the corresponding amide (I).

Abstract: This invention relates to a process for preparing optically active ?-amino acid substrates which are used to make potent lethal factor (LF) inhibitors for the treatment of anthrax. This invention further relates to a process for synthesis of potent LF-inhibitors for the treatment of anthrax. Specifically, the invention concerns a novel, high-yielding and highly enantioselective asymmetric hydrogenation reaction of a tetrasubstituted ene-sulfonamide acid or ester.

Abstract: Embodiments provide a method of refilling an inkjet printer cartridge. The method includes providing an inkjet printer cartridge and lowering the pressure surrounding the cartridge below atmospheric level. A first volume of ink is directed into the cartridge at the reduced pressure. The method further includes at least partially raising the pressure surrounding the cartridge and subsequently at least partially lowering the pressure surrounding the cartridge. A second volume of ink is then directed into the cartridge at the second reduced pressure.