Patents by Inventor Scott Sternson

Scott Sternson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE
    Publication number: 20260159560
    Abstract: This document relates to materials and methods for controlling ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
    Type: Application
    Filed: February 4, 2026
    Publication date: June 11, 2026
    Inventors: Scott Sternson, Peter Lee, Christopher Magnus
  • MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE
    Publication number: 20260098076
    Abstract: This document relates to materials and methods for modulating ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
    Type: Application
    Filed: February 24, 2025
    Publication date: April 9, 2026
    Inventors: Scott Sternson, Peter Lee, Christopher Magnus
  • Modified ligand-gated ion channels and methods of use
    Patent number: 12570705
    Abstract: This document relates to materials and methods for controlling ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: March 10, 2026
    Assignee: Howard Hughes Medical Institute
    Inventors: Scott Sternson, Peter Lee, Christopher Magnus
  • Modified ligand-gated ion channels and methods of use
    Patent number: 12570706
    Abstract: This document relates to materials and methods for controlling ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: March 10, 2026
    Assignee: Howard Hughes Medical Institute
    Inventors: Scott Sternson, Peter Lee, Christopher Magnus
  • MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE
    Publication number: 20250145687
    Abstract: This document relates to materials and methods for modulating ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
    Type: Application
    Filed: January 31, 2023
    Publication date: May 8, 2025
    Inventor: Scott Sternson
  • Modified ligand-gated ion channels and methods of use
    Patent number: 12247064
    Abstract: This document relates to materials and methods for modulating ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: March 11, 2025
    Assignee: Howard Hughes Medical Institute
    Inventors: Scott Sternson, Peter Lee, Christopher Magnus
  • CHEMOGENETIC RECEPTORS AND METHODS OF MAKING AND USING
    Publication number: 20240002463
    Abstract: This disclosure describes a number of chemogenetic receptors that bind an ingested substance that reinforces its own ingestion or administration (e.g., an addictive drug) and, upon binding of the molecule, modulate the function of a cell.
    Type: Application
    Filed: April 27, 2023
    Publication date: January 4, 2024
    Inventors: Scott Sternson, Christopher Magnus
  • MATERIALS AND METHODS FOR SERIAL MULTIPLEXED DETECTION OF RNA IN CELLS AND TISSUES
    Publication number: 20220298563
    Abstract: This disclosure describes materials and methods for effectively performing serial multiplexed FISH analysis.
    Type: Application
    Filed: June 6, 2022
    Publication date: September 22, 2022
    Inventors: Scott Sternson, Fredrick Henry, Hui Yang, Shengjin Xu
  • Materials and methods for serial multiplexed detection of RNA in cells and tissues
    Patent number: 11352660
    Abstract: This disclosure describes materials and methods for effectively performing serial multiplexed FISH analysis.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: June 7, 2022
    Assignee: Howard Hughes Medical Institute
    Inventors: Scott Sternson, Fredrick Henry, Hui Yang, Shengjin Xu
  • MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE
    Publication number: 20220041671
    Abstract: This document relates to materials and methods for controlling ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
    Type: Application
    Filed: August 9, 2021
    Publication date: February 10, 2022
    Inventors: Scott Sternson, Peter Lee, Christopher Magnus
  • MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE
    Publication number: 20210403522
    Abstract: This document relates to materials and methods for controlling ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
    Type: Application
    Filed: September 8, 2021
    Publication date: December 30, 2021
    Inventors: Scott Sternson, Peter Lee, Christopher Magnus
  • Modified ligand-gated ion channels and methods of use
    Patent number: 11124554
    Abstract: This document relates to materials and methods for controlling ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: September 21, 2021
    Assignee: Howard Hughes Medical Institute
    Inventors: Scott Sternson, Peter Lee, Christopher Magnus
  • Modified ligand-gated ion channels and methods of use
    Patent number: 11084853
    Abstract: This document relates to materials and methods for controlling ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: August 10, 2021
    Assignee: Howard Hughes Medical Institute
    Inventors: Scott Sternson, Peter Lee, Christopher Magnus
  • MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE
    Publication number: 20210206831
    Abstract: This document relates to materials and methods for modulating ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
    Type: Application
    Filed: January 12, 2021
    Publication date: July 8, 2021
    Inventors: Scott Sternson, Peter Lee, Christopher Magnus
  • Modified ligand-gated ion channels and methods of use
    Patent number: 10981962
    Abstract: This document relates to materials and methods for controlling ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: April 20, 2021
    Assignee: Howard Hughes Medical Institute
    Inventors: Scott Sternson, Peter Lee, Christopher Magnus
  • Modified ligand-gated ion channels and methods of use
    Patent number: 10961296
    Abstract: This document relates to materials and methods for modulating ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: March 30, 2021
    Assignee: Howard Hughes Medical Institute
    Inventors: Scott Sternson, Peter Lee, Christopher Magnus
  • MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE
    Publication number: 20200377566
    Abstract: This document relates to materials and methods for controlling ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
    Type: Application
    Filed: May 6, 2020
    Publication date: December 3, 2020
    Inventors: Scott Sternson, Peter Lee, Christopher Magnus
  • MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE
    Publication number: 20190375807
    Abstract: This document relates to materials and methods for controlling ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
    Type: Application
    Filed: August 19, 2019
    Publication date: December 12, 2019
    Inventors: Scott Sternson, Peter Lee, Christopher Magnus
  • MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE
    Publication number: 20190169264
    Abstract: This document relates to materials and methods for modulating ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
    Type: Application
    Filed: November 9, 2018
    Publication date: June 6, 2019
    Inventors: Scott Sternson, Peter Lee, Christopher Magnus
  • MATERIALS AND METHODS FOR SERIAL MULTIPLEXED DETECTION OF RNA IN CELLS AND TISSUES
    Publication number: 20180094305
    Abstract: This disclosure describes materials and methods for effectively performing serial multiplexed FISH analysis.
    Type: Application
    Filed: October 4, 2017
    Publication date: April 5, 2018
    Inventors: Scott Sternson, Fredrick Henry, Hui Yang, Shengjin Xu