Abstract: Described are compositions and methods relating to a coated granule comprising a core coated with cross-linkable polymer, where the cross-linkable polymer is applied using a feed suspension that includes an acid-neutralized volatile base and a calcium salt insoluble at the pH of the neutralized feed suspension. Volatilization of the base decreases the pH of the feed suspension, thereby solubilizing the calcium salt, and inducing in situ ion-mediated cross-linking of the cross-linkable polymer.

Abstract: Systems and methods are provided for microencapsulating oxygen sensitive cargo such as polyunsaturated fatty acids and other oils by spray drying with an in situ internal gelation mechanism achieving cross-linking of polymers during the process, which is well-suited for industrial scale-up. Spray drying formulations of a mixture of an immiscible hydrophobic cargo and an emulsifier of a hydrophobically modified hydrophilic polymer with a suspension of a multivalent ion cross-linkable polymer, at least one acid, at least one volatile base and at least one salt of a multivalent ion can be adapted to provide control over particle size, degree of crosslinking, enteric release of cargo and shelf life. The methods produce microcapsules that enhance the shelf life of lipophilic bioactives while providing a mechanism of gastrointestinal delivery.

Abstract: Microencapsulation methods are provided using encapsulant, fiber or film forming compositions of a cross-linkable anionic polymer, a multivalent cation salt, a chelating agent, and a volatile base. During the formation of this composition, the generally acidic chelating agent is titrated with a volatile base to an elevated pH to improve ion-binding capability. Multivalent cations are sequestered in cation-chelate complexes. Cross-linkable polymers in this solution will remain freely dissolved until some disruption of equilibrium induces the release of the free multivalent cations from the cation-chelate complex. Vaporization of the volatile base drops the pH of the solution causing the cation-chelate complexes to dissociate and liberate multivalent cations that associate with the anionic polymer to form a cross-linked matrix. During spray-drying, the formation of a wet particle, polymer cross-linking, and particle drying occur nearly simultaneously.

Abstract: Microencapsulation of bioactive and chemical cargo in a stable, cross-linked polymer matrix is presented that results in small particle sizes and is easily scaled-up for industrial applications. A formulation of a salt of an acid soluble multivalent ion, an acid neutralized with a volatile base and one or more monomers that cross-link in the presence of multivalent ions is atomized into droplets. Cross-linking is achieved upon atomization where the volatile base is vaporized resulting in a reduction of the pH of the formulation and the temporal release of multivalent ions from the salt that cross-link the monomers forming a capsule. The incorporation of additional polymers or hydrophobic compounds in the formulation allows control of hydration properties of the particles to control the release of the encapsulated compounds. The operational parameters can also be controlled to affect capsule properties such as particle-size and particle-size distribution.

Abstract: Provided is a process, including: obtaining a plurality of network-traffic pattern specifications; obtaining network traffic data captured as the network traffic data is leaving from, arriving to, or looping back at a network interface of a computing device; comparing the plurality of network-traffic pattern specifications to the network traffic data; detecting based on the comparing, a match between at least a portion of the network traffic data and a matching network-traffic pattern specification among the plurality of network-traffic pattern specifications; and causing adding or adjusting one or more instances of one or more monitoring agents monitoring the instance of a service based on the detected match and the respective monitoring agent or monitoring agent configuration setting associated with the matching network-traffic pattern specification.

Abstract: Provided is a process including: obtaining, with one or more processors, network-traffic data describing a graph of network traffic among a plurality of hosts of one or more distributed applications executing on a plurality of computing devices between which the network traffic is sent; inferring, with one or more processors, a topology of a first distributed application among the one or more distributed applications based on the network-traffic data; causing, with one or more processors, a visual representation of the topology to be presented in a graphical user interface.

Abstract: Provided is a process, including: obtaining a plurality of network-traffic pattern specifications; obtaining network traffic data captured as the network traffic data is leaving from, arriving to, or looping back at a network interface of a computing device; comparing the plurality of network-traffic pattern specifications to the network traffic data; detecting based on the comparing, a match between at least a portion of the network traffic data and a matching network-traffic pattern specification among the plurality of network-traffic pattern specifications; and causing adding or adjusting one or more instances of one or more monitoring agents monitoring the instance of a service based on the detected match and the respective monitoring agent or monitoring agent configuration setting associated with the matching network-traffic pattern specification.

Abstract: Provided is a process including: obtaining, with one or more processors, network-traffic data describing a graph of network traffic among a plurality of hosts of one or more distributed applications executing on a plurality of computing devices between which the network traffic is sent; inferring, with one or more processors, a topology of a first distributed application among the one or more distributed applications based on the network-traffic data; causing, with one or more processors, a visual representation of the topology to be presented in a graphical user interface.

Abstract: A clustered server system and a method for maintaining a server cluster involve a plurality of servers that collectively form a server cluster. A master database stores configuration information concerning the server cluster. Each server stores a local copy of the configuration information in a file system. The servers automatically update their respective file system using a database copy of the configuration information if the configuration information changes in the database.

Abstract: Microencapsulation of bioactive and chemical cargo in a stable, cross-linked polymer matrix is presented that results in small particle sizes and is easily scaled-up for industrial applications. A formulation of a salt of an acid soluble multivalent ion, an acid neutralized with a volatile base and one or more monomers that cross-link in the presence of multivalent ions is atomized into droplets. Cross-linking is achieved upon atomization where the volatile base is vaporized resulting in a reduction of the pH of the formulation and the temporal release of multivalent ions from the salt that cross-link the monomers forming a capsule. The incorporation of additional polymers or hydrophobic compounds in the formulation allows control of hydration properties of the particles to control the release of the encapsulated compounds. The operational parameters can also be controlled to affect capsule properties such as particle-size and particle-size distribution.

Abstract: Microencapsulation of bioactive and chemical cargo in a stable, cross-linked polymer matrix is presented that results in small particle sizes and is easily scaled-up for industrial applications. A formulation of a salt of an acid soluble multivalent ion, an acid neutralized with a volatile base and one or more monomers that cross-link in the presence of multivalent ions is atomized into droplets. Cross-linking is achieved upon atomization where the volatile base is vaporized resulting in a reduction of the pH of the formulation and the temporal release of multivalent ions from the salt that cross-link the monomers forming a capsule. The incorporation of additional polymers or hydrophobic compounds in the formulation allows control of hydration properties of the particles to control the release of the encapsulated compounds. The operational parameters can also be controlled to affect capsule properties such as particle-size and particle-size distribution.

Abstract: A clustered server system and a method for maintaining a server cluster involve a plurality of servers that collectively form a server cluster. A master database stores configuration information concerning the server cluster. Each server stores a local copy of the configuration information in a file system. The servers automatically update their respective file system using a database copy of the configuration information if the configuration information changes in the database.

Abstract: In an example embodiment, a container is downloaded, the container being an application natively executable by a first operating system of the user device, the container including: a container service including one or more libraries of functions designed by a container designer to natively operate on the first operating system; a browser; container metadata defining functions of the application, the functions compatible with the container service for the first operating system and also compatible with a container service for a second operating system; and a plug-in including one or more additional libraries of functions designed by an entity other than the container designer to perform additional native operations on the first operating system. Then, the container metadata can be executed using the browser, causing function calls to the container service and plug-in and thus controlling native functions of the user device.

Abstract: In an example embodiment, a container is downloaded, the container being an application natively executable by a first operating system of the user device, the container including: a container service including one or more libraries of functions designed by a container designer to natively operate on the first operating system; a browser; container metadata defining functions of the application, the functions compatible with the container service for the first operating system and also compatible with a container service for a second operating system; and a plug-in including one or more additional libraries of functions designed by an entity other than the container designer to perform additional native operations on the first operating system. Then, the container metadata can be executed using the browser, causing function calls to the container service and plug-in and thus controlling native functions of the user device.

Abstract: Microencapsulation of bioactive and chemical cargo in a stable, cross-linked polymer matrix is presented that results in small particle sizes and is easily scaled-up for industrial applications. A formulation of a salt of an acid soluble multivalent ion, an acid neutralized with a volatile base and one or more monomers that cross-link in the presence of multivalent ions is atomized into droplets. Cross-linking is achieved upon atomization where the volatile base is vaporized resulting in a reduction of the pH of the formulation and the temporal release of multivalent ions from the salt that cross-link the monomers forming a capsule. The incorporation of additional polymers or hydrophobic compounds in the formulation allows control of hydration properties of the particles to control the release of the encapsulated compounds. The operational parameters can also be controlled to affect capsule properties such as particle-size and particle-size distribution.

Abstract: The glmS riboswitch is a target for antibiotics and other small molecule therapies. Compounds can be used to stimulate, active, inhibit and/or inactivate the glmS riboswitch. The atomic structures of the glmS riboswitch can be used to design new compounds to stimulate, active, inhibit and/or inactivate riboswitches.