Abstract: This disclosure relates to methods of treating a copper metabolism-associated disease or disorder, such as Wilson disease (WD). This disclosure also relates to methods of sequestering copper in a subject or of mobilizing copper into plasma in a subject.

Abstract: Disclosed are methods of treating a copper metabolism-associated disease or disorder, such as Wilson disease (WD) in a subject, particularly in a subject who is from about 3 years old to less than about 18 years old. Also disclosed are compositions comprising bis-choline tetrathiomolybdate for use in the treatment of a copper metabolism-associated disease or disorder, such as Wilson disease (WD) in a subject, particularly in a subject who is from about 3 years old to less than about 18 years old. Also disclosed are uses of a composition comprising bis-choline tetrathiomolybdate for the manufacture of a medicament for treating a copper metabolism-associated disease or disorder, such as Wilson disease (WD) in a subject, particularly in a subject who is from about 3 years old to less than about 18 years old.

Abstract: This disclosure relates to methods of diagnosing and treating a copper metabolism-associated disease or disorder, such as Wilson disease (WD).

Abstract: Provided are methods for clinical treatment of Atypical Hemolytic Uremic Syndrome (aHUS) using an anti-C5 antibody, or antigen binding fragment thereof.

Abstract: Provided are methods for clinical treatment of Atypical Hemolytic Uremic Syndrome (aHUS) using an anti-C5 antibody, or antigen binding fragment thereof, in pediatric patients.

Abstract: A method for generating instructions for servicing a vehicle, the method comprising: receiving fault data related to a fault of the vehicle to a database, wherein the fault data is generated by a diagnostic system of the vehicle, and wherein the database comprises technical information of at least a portion of the vehicle and information related to one or more faults of the vehicle; sending, to a mobile device, solution data addressing the fault, wherein the solution data identifies a defective part in the vehicle; receiving an image of an object associated with the vehicle, wherein the image is captured by an image sensor on the mobile device; determining a location of the mobile device in a three-dimensional model of the vehicle based on the image; sending computer-executable programing instructions on performing an augmented reality procedure for displaying, on the mobile device, a route from the mobile device to the defective part, and instructions on servicing the defective part; after the defective part

Abstract: A system for maintaining a minimum clearance between a locomotive and a railway infrastructure is provided. The system includes at least one rollable and compressible device configured to be affixed or otherwise provided on a side of a locomotive or portion of a train. Each rollable and compressible device includes bi-directional rolling element and is configured to allow movement of the roller between a non-rolling state and a rolling state and between an uncompressed state and a predetermined maximum compressed state.

Abstract: A system for maintaining a minimum clearance between a locomotive and a railway infrastructure is provided. The system includes at least one rollable and compressible device configured to be affixed or otherwise provided on a side of a locomotive or portion of a train. Each rollable and compressible device includes bi-directional rolling element and is configured to allow movement of the roller between a non-rolling state and a rolling state and between an uncompressed state and a predetermined maximum compressed state.

Abstract: A modular assembly for a heat exchanger is provided. The modular assembly includes a support assembly configured to couple to a base section of a hood structure of the heat exchanger. The support assembly includes a first slant surface and a second slant surface configured to provide support to at least a portion of the heat exchanger. The support assembly also includes a fluid reservoir integrated with and extending from the support assembly, the fluid reservoir is configured to store a fluid circulated through the heat exchanger.

Abstract: A modular assembly for a heat exchanger is provided. The modular assembly includes a support assembly configured to couple to a base section of a hood structure of the heat exchanger. The support assembly includes a first slant surface and a second slant surface configured to provide support to at least a portion of the heat exchanger. The support assembly also includes a fluid reservoir integrated with and extending from the support assembly, the fluid reservoir is configured to store a fluid circulated through the heat exchanger.

Abstract: An apparatus for displaying a road number for a locomotive includes a bracket, a polyhedral housing, an LED-based illumination source, and a display plate. The bracket is configured to be rigidly affixed to a nose portion of the locomotive. The polyhedral housing includes a first side and a second side. The first side is disposed within the bracket. The second side is disposed in a spaced-apart relation to the first side. The second side is configured to releasably engage with the bracket and receive a transparent cover thereon. The LED-based illumination source is disposed between the first side and the transparent cover. The display plate is disposed between the LED-based illumination source and the transparent cover. The display plate includes one or more alpha-numerals scripted thereon, wherein the alpha-numerals are representative of the road number.

Abstract: An antenna array for a body panel of a locomotive is described having a base support including at least a pair of elongated parallel structures forming a channel on the body panel of the locomotive cab. A plurality of removable plates are affixed to the elongated parallel structures for mounting an antenna on each of the removable plates, thereby allowing wiring from each antenna to extend from its respective removable plate through the channel formed by the base support. A junction box situated near the base support forms an enclosure about an aperture formed in the body panel of the locomotive. The junction box includes a plurality of interconnects for connecting wiring of each antenna to wiring of a device in the locomotive. In one embodiment, the junction box is integral to the base support. The integral junction box, base support arrangement may further include a lip formed about its periphery in which a cover mounted thereon.

Abstract: An antenna array for a body panel of a locomotive is described having a base support including at least a pair of elongated parallel structures forming a channel on the body panel of the locomotive cab. A plurality of removable plates are affixed to the elongated parallel structures for mounting an antenna on each of the removable plates, thereby allowing wiring from each antenna to extend from its respective removable plate through the channel formed by the base support. A junction box situated near the base support forms an enclosure about an aperture formed in the body panel of the locomotive. The junction box includes a plurality of interconnects for connecting wiring of each antenna to wiring of a device in the locomotive. In one embodiment, the junction box is integral to the base support. The integral junction box, base support arrangement may further include a lip formed about its periphery in which a cover mounted thereon.

Abstract: A wireless communication system (100), method, and base station (112) are provided for optimizing performance of a base station receiver (120). The method includes selecting an interpolation matrix (216) specially tailored for particular channel characteristics from a pre-defined set of interpolation matrices (218), and using the selected interpolation matrix in the channel estimation, and applying the derived channel estimates for the data subcarriers to an equalizer (118) as a set of weights. The interpolation matrix (216) is selected by using the matrix corresponding to a received channel profile information, or by monitoring a performance metric (212) while using each interpolation matrix of a pre-defined set of matrices in the channel estimation and applying the derived channel estimates for the data subcarriers as a set of weights to the receiver equalizer (118) and selecting the matrix resulting in best performance.

Abstract: In a Time Division Multiple Access System, multiple offset values are provided to a divider control circuit (213) of a fractional-N synthesizer (200) by utilizing a microprocessor (305). The microprocessor (305) utilizes timeslot information provided to it by a timeslot selector (301), frequency information provided to it by a frequency selector (303) and a read-only memory (307), to provide offset values to the divider control circuit (213).