Patents by Inventor Scott T. Quarmby

Scott T. Quarmby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210111013
    Abstract: A tuning system may acquire, from a mass spectrometer during a batch of one or more analytical runs performed with the mass spectrometer, tune data associated with an operating characteristic of the mass spectrometer. The tuning system may determine, based on the tune data, a value of an operating parameter configured to adjust the operating characteristic of the mass spectrometer and set the operating parameter to the determined value.
    Type: Application
    Filed: October 11, 2019
    Publication date: April 15, 2021
    Inventors: Scott T. QUARMBY, Giacinto ZILIOLI, Charles H. VOGT, Dustin J. KREFT, Nathaniel L. SANDERS, George B. GUCKENBERGER, John G. VOSS
  • Publication number: 20210072204
    Abstract: A mass spectrometry system having a simplified control interface includes a processor and a memory. The memory includes instructions that when executed cause the processor to perform the steps of providing a user interface including a plurality of adjustment elements for adjusting at least one results effective parameter and at least one sample descriptive parameter; determining a plurality of instrument control parameters based on the at least one results effective parameter and the at least one sample descriptive parameter; and analyzing a sample while operating according to the plurality of instrument control parameters.
    Type: Application
    Filed: October 28, 2020
    Publication date: March 11, 2021
    Inventors: Joshua T. MAZE, Scott T. QUARMBY
  • Patent number: 10823714
    Abstract: A mass spectrometry system having a simplified control interface includes a processor and a memory. The memory includes instructions that when executed cause the processor to perform the steps of providing a user interface including a plurality of adjustment elements for adjusting at least one results effective parameter and at least one sample descriptive parameter; determining a plurality of instrument control parameters based on the at least one results effective parameter and the at least one sample descriptive parameter; and analyzing a sample while operating according to the plurality of instrument control parameters.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: November 3, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventors: Joshua T. Maze, Scott T. Quarmby
  • Patent number: 10784095
    Abstract: A mass spectrometer is described that includes a multipole configured to pass an ion stream, the ion stream comprising an abundance of one or more ion species within stability boundaries defined by (a, q) values. A detector formed by a plurality of dynodes is configured to detect the spatial and temporal properties of the abundance of ions, where each dynode arranged such that it is struck by ions in a known spatial relationship with the ion stream. The detector also includes a plurality of charged particle detectors, each associated with one or more of the plurality of dynodes. A processing system is configured to record and store a pattern of detection of ions in the abundance of ions by the dynodes in the detector.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: September 22, 2020
    Assignee: Thermo Finnigan LLC
    Inventors: Johnathan W. Smith, Scott T. Quarmby
  • Patent number: 10755914
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: August 25, 2020
    Assignee: Thermo Finnigan LLC
    Inventors: Edward B. McCauley, Scott T. Quarmby, George B. Guckenberger, James M. Hitchcock
  • Publication number: 20200194245
    Abstract: A mass spectrometer is described that includes a multipole configured to pass an ion stream, the ion stream comprising an abundance of one or more ion species within stability boundaries defined by (a, q) values. A detector formed by a plurality of dynodes is configured to detect the spatial and temporal properties of the abundance of ions, where each dynode arranged such that it is struck by ions in a known spatial relationship with the ion stream. The detector also includes a plurality of charged particle detectors, each associated with one or more of the plurality of dynodes. A processing system is configured to record and store a pattern of detection of ions in the abundance of ions by the dynodes in the detector.
    Type: Application
    Filed: December 18, 2018
    Publication date: June 18, 2020
    Inventors: Johnathan W. SMITH, Scott T. QUARMBY
  • Patent number: 10672597
    Abstract: An ion detector includes a first stage dynode configured to receive an ion beam and generate electrons, a photon source arranged to provide photons to the first stage dynode, the photons of sufficient energy to cause the first stage dynode to emit photoelectrons, an electron multiplier configured to receive the electrons or the photoelectrons from the first stage dynode and generate an output proportional to the number of electrons or photoelectrons, and a controller. The controller is configured to receive the output generated in response to the photoelectrons; calculate a gain curve of the detector based on the output; and set a voltage of the electron multiplier or the first stage dynode to achieve a target gain for the ion beam.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: June 2, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventors: Joshua T. Maze, Edward B. McCauley, Scott T. Quarmby
  • Publication number: 20200111657
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Application
    Filed: December 5, 2019
    Publication date: April 9, 2020
    Inventors: Edward B. McCAULEY, Scott T. QUARMBY, George B. GUCKENBERGER, James M. HITCHCOCK
  • Patent number: 10598641
    Abstract: A method of assessing the linearity and dynamic range of a mass spectrometer is described comprising analyzing two or more test standards containing positional isomers, for example, using a series of N isomeric analytes with or without an internal standard where N is an integer from 2 to 6 inclusive. The concentrations of the N isomeric analytes may or may not be interleaved between two or more standards. The method allows for repeated instrument characterization without having many of the problems associated with using only a single standard such as octafluoronaphthalene (OFN), for example, persistence, and it may lessen sample carryover issues between adjacent samples. Methods are described using positional isomers of dibromodifluorobenzene in various configurations that show an improved means for qualitative and quantitative analysis of one or more analytes by GC-MS.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: March 24, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventors: Edward B. McCauley, Scott T. Quarmby
  • Patent number: 10566180
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: February 18, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventors: Edward B. McCauley, Scott T. Quarmby, George B. Guckenberger, James M. Hitchcock
  • Publication number: 20200020518
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Application
    Filed: July 11, 2018
    Publication date: January 16, 2020
    Inventors: Edward B. McCAULEY, Scott T. QUARMBY, George B. GUCKENBERGER, James M. HITCHCOCK
  • Publication number: 20200020513
    Abstract: An ion detector includes a first stage dynode configured to receive an ion beam and generate electrons, a photon source arranged to provide photons to the first stage dynode, the photons of sufficient energy to cause the first stage dynode to emit photoelectrons, an electron multiplier configured to receive the electrons or the photoelectrons from the first stage dynode and generate an output proportional to the number of electrons or photoelectrons, and a controller. The controller is configured to receive the output generated in response to the photoelectrons; calculate a gain curve of the detector based on the output; and set a voltage of the electron multiplier or the first stage dynode to achieve a target gain for the ion beam.
    Type: Application
    Filed: July 11, 2018
    Publication date: January 16, 2020
    Inventors: Joshua T. MAZE, Edward B. McCAULEY, Scott T. QUARMBY
  • Patent number: 10529550
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: January 7, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventors: Edward B. McCauley, Scott T. Quarmby, George B. Guckenberger, James M. Hitchcock
  • Patent number: 10515789
    Abstract: A method of operating a mass spectrometer comprising: detecting a first ion species using a first gain setting of a detector or a first emission current for a first mass-to-charge range; detecting a second ion species using a second gain setting of the detector or a second emission current for a second mass-to-charge range; and using the detected first and second ion species to calibrate the mass range of a mass analyzer of the mass spectrometer, to tune the resolution of the mass analyzer, or to tune an ion optic of the mass spectrometer.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: December 24, 2019
    Assignee: THERMO FINNIGAN LLC
    Inventors: George B. Guckenberger, Scott T. Quarmby, John G. Voss, Michael B. Young
  • Patent number: 10438782
    Abstract: A method includes producing ions from one or more calibrant species and delivering the ions to a mass analyzer, and measuring a first set of mass related physical values for the ions from the one or more calibrant species. The method further includes producing ions from a sample and delivering the ions to a mass analyzer, and measuring a second mass related physical value for a first sample ion species. The first sample ion species has a mass-to-charge ratio outside of the range of the mass-to-charge ratios of the calibrant ion species. Additionally, the method includes calculating a calibration curve based on the first set of mass related physical values and second mass related physical value, and modifying at least one instrument parameter based on the calibration curve.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: October 8, 2019
    Assignee: Thermo Finnigan LLC
    Inventors: Scott T. Quarmby, George B. Guckenberger
  • Publication number: 20190195843
    Abstract: A method of assessing the linearity and dynamic range of a mass spectrometer is described comprising analyzing two or more test standards containing positional isomers, for example, using a series of N isomeric analytes with or without an internal standard where N is an integer from 2 to 6 inclusive. The concentrations of the N isomeric analytes may or may not be interleaved between two or more standards. The method allows for repeated instrument characterization without having many of the problems associated with using only a single standard such as octafluoronaphthalene (OFN), for example, persistence, and it may lessen sample carryover issues between adjacent samples. Methods are described using positional isomers of dibromodifluorobenzene in various configurations that show an improved means for qualitative and quantitative analysis of one or more analytes by GC-MS.
    Type: Application
    Filed: December 17, 2018
    Publication date: June 27, 2019
    Inventors: Edward B. McCAULEY, Scott T. QUARMBY
  • Publication number: 20190172692
    Abstract: A method includes producing ions from one or more calibrant species and delivering the ions to a mass analyzer, and measuring a first set of mass related physical values for the ions from the one or more calibrant species. The method further includes producing ions from a sample and delivering the ions to a mass analyzer, and measuring a second mass related physical value for a first sample ion species. The first sample ion species has a mass-to-charge ratio outside of the range of the mass-to-charge ratios of the calibrant ion species. Additionally, the method includes calculating a calibration curve based on the first set of mass related physical values and second mass related physical value, and modifying at least one instrument parameter based on the calibration curve.
    Type: Application
    Filed: February 5, 2019
    Publication date: June 6, 2019
    Inventors: Scott T. QUARMBY, George B. GUCKENBERGER
  • Patent number: 10242850
    Abstract: A method includes producing ions from one or more calibrant species and delivering the ions to a mass analyzer, and measuring a first set of mass related physical values for the ions from the one or more calibrant species. The method further includes producing ions from a sample and delivering the ions to a mass analyzer, and measuring a second mass related physical value for a first sample ion species. The first sample ion species has a mass-to-charge ratio outside of the range of the mass-to-charge ratios of the calibrant ion species. Additionally, the method includes calculating a calibration curve based on the first set of mass related physical values and second mass related physical value, and modifying at least one instrument parameter based on the calibration curve.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: March 26, 2019
    Assignee: THERMO FINNIGAN LLC
    Inventors: Scott T. Quarmby, George B. Guckenberger
  • Patent number: 10229825
    Abstract: A mass spectrometer system can include an ion source, a vacuum chamber; a mass analyzer within the vacuum chamber, a transfer tube between the ion source and the vacuum chamber, a transfer tube heater, and a vacuum pump. The mass spectrometer system can be configured to reduce the pump speed of the vacuum pump in response to receiving a transfer tube swap instruction; lower the temperature of the transfer tube to below a first threshold; operating the vacuum pump at the reduced pump speed while the transfer tube is replaced with a second transfer tube; heating the second transfer tube to a temperature above a pump down temperature; and increasing the pump speed of the vacuum pump after the temperature of the second transfer tube exceeds a second threshold.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: March 12, 2019
    Assignee: THERMO FINNIGAN LLC
    Inventors: Scott T. Quarmby, Edward B. McCauley, Joshua T. Maze
  • Patent number: 10204776
    Abstract: A mass spectrometry apparatus includes an ion source configured to generate ions; an ion guide configured to guide ions from the ion source towards a detector; the ion detector configured to detect ions; and a mass spectrometry controller. The mass spectrometry controller is configured to generate a tune curve for the ion guide; determine an observed low mass cutoff for the ion guide from the tune curve; calculate an effective r0 for the ion guide based on the observed low mass cutoff; determine an RF voltage based on the effective r0; apply the RF voltage to the ion guide; and perform a mass analysis of ions in a sample.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: February 12, 2019
    Assignee: THERMO FINNIGAN LLC
    Inventors: Scott T. Quarmby, Joshua T. Maze, Nathaniel L. Sanders