Abstract: The present invention relates to an optical modulator including an optical waveguide, and at least one CPW-to-CPS transition. The CPW segments include a hot electrode; and a ground plane disposed on each side of the hot electrode, and they share a ground plane. The CPS segment extends along an interaction length of the modulator. In one embodiment, two driving signals are applied so that the modulator operates as a dual-drive modulator. In another embodiment, a domain-inverted region is formed in a substrate of the dual-drive modulator to overlap with one arm of the optical waveguide (MZI) and invert a sign of a phase shift induced in that arm. Finally, a fixed chirp can be introduced into the dual-drive modulator by asymmetrically positioning the interferometer arms into gaps of the CPW segments with respect to the hot electrode, and by employing unequal width gaps in the CPW segments.

Abstract: The present invention relates to an optical modulator including an optical waveguide, and at least one CPW-to-CPS transition. The CPW segments include a hot electrode; and a ground plane disposed on each side of the hot electrode, and they share a ground plane. The CPS segment extends along an interaction length of the modulator. In one embodiment, two driving signals are applied so that the modulator operates as a dual-drive modulator. In another embodiment, a domain-inverted region is formed in a substrate of the dual-drive modulator to overlap with one arm of the optical waveguide (MZI) and invert a sign of a phase shift induced in that arm. Finally, a fixed chirp can be introduced into the dual-drive modulator by asymmetrically positioning the interferometer arms into gaps of the CPW segments with respect to the hot electrode, and by employing unequal width gaps in the CPW segments.

Abstract: The present invention relates to:(1) a fusion protein having a dimerizing domain with or without a ligand-binding region and toxR DNA-binding and hydrophobic transmembrane regions;(2) host cells comprising the fusion protein and a nucleic acid molecule having a reporter gene operatively linked to the ctx operon, wherein dimerization (ligand-dependent or -independent) is signaled by expression of the reporter gene;(3) a nucleic acid molecule coding for the fusion protein;(4) an expression vector comprising a coding region for the fusion protein;(5) a process for detecting dimer formation (ligand dependent or ligand independent) of the fusion protein, which comprises treating a culture of the host cells with a ligand, ligand mimetic, or dimerization inhibitor, and screening for expression of the reporter gene.The present invention can be used to generate a signal from a variety of ligand-binding domains, allowing ligand binding to be indicated by a simple colorimeteric test or antibiotic resistance.

Abstract: Expression vectors for human topoisomerase I and a method for detecting poisons of human topoisomerase I. The vector preferably contains a promoter, DNA coding for human topoisomerase I, DNA coding for a selectable marker, an origin of replication, and lac I.sup.q DNA which encodes a repressor for the promoter.

Abstract: Hayumicin compounds, obtainable by cultivation of a strain of Actinomadura sp. designated ATCC 55432, and analogs of these compounds. The novel compounds have antitumor as well as antibiotic, particularly antibacterial, activity.

Abstract: The present invention relates to:(1) a fusion protein having a dimerizing domain with or without a ligand-binding region and toxR DNA-binding and hydrophobic transmembrane regions;(2) host cells comprising the fusion protein and a nucleic acid molecule having a reporter gene operatively linked to the ctx operon, wherein dimerization (ligand-dependent or -independent) is signaled by expression of the reporter gene;(3) a nucleic acid molecule coding for the fusion protein;(4) an expression vector comprising a coding region for the fusion protein;(5) a process for detecting dimer formation (ligand dependent or ligand independent) of the fusion protein, which comprises treating a culture of the host cells with a ligand, ligand mimetic, or dimerization inhibitor, and screening for expression of the reporter gene.The present invention can be used to generate a signal from a variety of ligand-binding domains, allowing ligand binding to be indicated by a simple colorimetric test or antibiotic resistance.