Patents by Inventor Scott Thomas Brady

Scott Thomas Brady has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition and method for preventing or treating a tauopathy
    Patent number: 9862761
    Abstract: The present invention is a composition and method for the prevention and treatment of a tauopathy. The composition of the invention includes N-terminal amino acid residues of the tau protein, which have been identified as being involved in toxic activation of a PP1/GSK3 signaling cascade and inhibition of fast axonal transport in human tauopathies.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: January 9, 2018
    Assignees: The Board of Trustes of the University of Illinois, Northwestern University
    Inventors: Scott Thomas Brady, Lester I. Binder, Gerardo Andres Morfini, Nicholas M. Kanaan, Nichole E. LaPointe
  • COMPOSITION AND METHOD FOR PREVENTING OR TREATING A TAUOPATHY
    Publication number: 20160031978
    Abstract: The present invention is a composition and method for the prevention and treatment of a tauopathy. The composition of the invention includes N-terminal amino acid residues of the tau protein, which have been identified as being involved in toxic activation of a PP1/GSK3 signaling cascade and inhibition of fast axonal transport in human tauopathies.
    Type: Application
    Filed: September 24, 2015
    Publication date: February 4, 2016
    Inventors: Scott Thomas Brady, Lester I. Binder, Gerardo Andres Morfini, Nicholas M. Kanaan, Nichole E. LaPointe
  • Method for treating a synucleinopathy
    Patent number: 8618063
    Abstract: The present invention relates to methods for restoring fast axonal transport in a cell which expresses a pathological synuclein protein and for treating a synucleinopathy using a Protein Kinase C mu or Src-Family Tyrosine Kinase inhibitor.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: December 31, 2013
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Scott Thomas Brady, Gerardo Andres Morfini
  • Compositions and Methods for Treating a Disease Mediated by Soluble Oligomeric Amyloid Beta
    Publication number: 20110305706
    Abstract: The present invention relates to methods for restoring fast axonal transport in a cell affected by oligomeric amyloid beta and for treating an oligomeric amyloid beta-mediated disease such as Alzheimer's disease using a Casein Kinase 2 inhibitor and, in some embodiments, a Glycogen Synthase Kinase 3 inhibitor.
    Type: Application
    Filed: February 22, 2010
    Publication date: December 15, 2011
    Inventors: Scott Thomas Brady, Gerardo Andres Morfini, Gustavo Pigino
  • Compositions and Methods for Treating Amyotrophic Lateral Sclerosis
    Publication number: 20100227793
    Abstract: The invention relates to methods for preserving fast axonal transport in a cell affected by Amyotrophic Lateral Sclerosis by inhibiting pathogenic superoxide dismutase-induced increases in p38? activity. The present invention also provides methods for identifying agents which inhibit the phosphorylation of the kinesin-1, as well as methods for monitoring treatment of Amyotrophic Lateral Sclerosis based on the phosphorylation of p38a, neurofilament heavy chain subunits, and serines 175 and/or 176 of kinesin-1.
    Type: Application
    Filed: March 4, 2010
    Publication date: September 9, 2010
    Inventors: Scott Thomas Brady, Gerardo Andres Morfini
  • Method for treating a synucleinopathy
    Publication number: 20090258814
    Abstract: The present invention relates to methods for restoring fast axonal transport in a cell which expresses a pathological synuclein protein and for treating a synucleinopathy using a Protein Kinase C mu or Src-Family Tyrosine Kinase inhibitor.
    Type: Application
    Filed: April 9, 2008
    Publication date: October 15, 2009
    Inventors: Scott Thomas Brady, Gerardo Andres Morfini
  • Compositions and Methods for Treating Polyglutamine-Expansion Neurodegenerative Diseases
    Publication number: 20090252717
    Abstract: The invention relates to methods for stimulating fast axonal transport in polyglutamine expansion diseases and treating polyglutamine expansion diseases by inhibiting SAPK-dependent phosphorylation of kinesin. The present invention also provides methods for identifying agents which inhibit the phosphorylation of the kinesin, as well as methods for monitoring treatment of a polyglutamine expansion disease based on the phosphorylation of serine 176 of kinesin-1A or kinesin-1C, or serine 175 of kinesin-1B.
    Type: Application
    Filed: May 29, 2007
    Publication date: October 8, 2009
    Inventors: Scott Thomas Brady, Gerardo Andres Morfini