Abstract: Provided herein are drug implants comprising a therapeutically active agent for the treatment of disease in a subject. In some cases, the drug implant may comprise a polymer matrix and a therapeutically active agent disposed therein. Additionally provided are methods for manufacturing the drug implants and methods of treating diseases with the implants. In some cases, the drug implant may comprise bicalutamide, e.g., for use in the treatment of prostate cancer.

Abstract: Provided herein are drug implants comprising a therapeutically active agent for the treatment of disease in a subject. In some cases, the drug implant may comprise a polymer matrix and a therapeutically active agent disposed therein. Additionally provided are methods for manufacturing the drug implants and methods of treating diseases with the implants. In some cases, the drug implant may comprise bicalutamide, e.g., for use in the treatment of prostate cancer.

Abstract: Provided herein are drug implants comprising a therapeutically active agent for the treatment of disease in a subject. In some cases, the drug implant may comprise a polymer matrix and a therapeutically active agent disposed therein. Additionally provided are methods for manufacturing the drug implants and methods of treating diseases with the implants. In some cases, the drug implant may comprise bicalutamide, e.g., for use in the treatment of prostate cancer.

Abstract: Methods and systems for improving vehicular safety by notifying vehicle operators of location-based risks are provided. According to embodiments, a processing server may receive an initial location of a vehicle. Based on location data associated with the initial location, the processing server can determine the risk of an incident. The processing server can generate a notification to communicate to the vehicle operator, and the vehicle operator can assess the risk and take action to mitigate the risk, for example by relocating the vehicle. The processing server can receive updated location data for the vehicle and can determine, based on the updated location data, that the risk has been mitigated.

Abstract: An actuation system for a control surface of an aircraft includes a drive lever. The drive lever includes a coupling end configured to pivotably couple to a plurality of wing attach fittings and a lever end. The lever end includes a first actuator fitting configured to pivotably couple to a first actuator on a forward side of the drive lever; a second actuator fitting configured to pivotably couple to a second actuator on an aft side of the drive lever; a first drive link fitting configured to couple, via a first drive link, to a control surface of an aircraft; and a second drive link fitting configured to couple, via a second drive link, to the control surface of the aircraft.

Abstract: A technique for speculatively executing load-dependent instructions includes detecting that a memory ordering consistency queue is full for a completed load instruction. The technique also includes storing data loaded by the completed load instruction into a storage location for storing data when the memory ordering consistency queue is full. The technique further includes speculatively executing instructions that are dependent on the completed load instruction. The technique also includes in response to a slot becoming available in the memory ordering consistency queue, replaying the load instruction. The technique further includes in response to receiving loaded data for the replayed load instruction, testing for a data mis-speculation by comparing the loaded data for the replayed load instruction with the data loaded by the completed load instruction that is stored in the storage location.

Abstract: A method of capturing soot includes the steps: combusting a first precursor in a burner to produce a soot stream, the soot stream comprising soot and exiting the burner at an outlet; and directing a capture medium to the soot stream, the capture medium contacting the soot in an impact region, the soot having a temperature greater than 50° C. in the impact region.

Abstract: The present disclosure provides systems and methods that combine direct capture of one or more moieties from a gaseous mixture with one or both of calcium oxide production and power production. The systems and methods can utilize combinations of a capture unit, a regeneration unit, a calcination unit, a slaking unit, a heat exchange unit, a separation unit, and a power production unit. The present disclosure provides the ability to remove carbon dioxide and other moieties from air or other gaseous mixtures in a truly carbon negative manner by utilizing electricity from a power production unit that is operated in a carbon neutral or carbon negative manner and simultaneously provide useful products, such as calcium oxide and calcium hydroxide.

Abstract: Voice command matching during testing of voice-assisted application prototypes for languages with non-phonetic alphabets is described. A visual page of an application prototype is displayed during a testing phase of the application prototype. A speech-to-text service converts a non-phonetic voice command spoken in a language with a non-phonetic alphabet, captured by at least one microphone during the testing phase of the application prototype, into a non-phonetic text string in the non-phonetic alphabet of the voice command. A phonetic language translator translates the non-phonetic text string of the voice command into a phonetic text string in a phonetic alphabet of the voice command. A comparison module compares the phonetic text string of the voice command to phonetic text strings in the phonetic alphabet of stored voice commands associated with the application prototype to identify a matching voice command. A performance module performs an action associated with the matching voice command.

Abstract: A design for the electrical infrastructure of a data center enables two different configurations to be utilized, including a distributed, redundant configuration that provides higher reliability and a non-redundant configuration that provides higher capacity. In the distributed, redundant configuration, each server in the data center draws power from at least two different power supply systems. This enables load shifting when a power supply system becomes unavailable, which can have the effect of increasing server reliability. In the non-redundant configuration, each server in the data center draws power from only one power supply system. Load shifting is not utilized in the non-redundant configuration, which eliminates the need to maintain reserve capacity and thereby increases capacity. Advantageously, it is possible to switch between these two configurations without making any internal changes to the data center other than modifying connections between sets of server racks and power buses.

Abstract: A method for localizing a device. The method is performed by a communication device. The method includes measuring a phase of a signal that the communication device has received from the device, the signal having a first frequency; measuring a phase of at least one further signal that the communication device has received from the device; the at least one further signal having a second frequency, determining a phase pattern of a measured phase versus frequency, pattern matching the phase pattern with each reference phase pattern of a plurality of pre-determined reference phase patterns. Each reference phase pattern is associated with a distance between the communication device and the further communication device. The method further includes determining the distance between the further communication device and the communication device based on the pattern matching.

Abstract: A computer implemented method for providing insurance comprises receiving a plurality of vehicle data including a start point, an end point and a frequency value. The method further comprises analyzing the plurality of vehicle data to determine a driving route associated with the vehicle. The method also comprises determining, based on the frequency value, that the driving route is a common driving route and a risk level of the common driving route. The method further comprises processing one or more insurance options, including pricing and underwriting, based at least in part on the risk level of the common driving route.

Abstract: A first power train that includes a first plurality of components, and a second power train includes a second plurality of components. The first power train is configured to provide power to a first plurality of server racks of a first data center at a first level of high-availability service associated with a first uptime. The first plurality of components includes a first subset of the first plurality of components and a second subset of the first plurality of components. The second power train is configured to provide power to a second plurality of server racks of the first data center at a second level of high-availability service that is associated with a second uptime that is less than the first uptime. The second plurality of components includes a first subset of the second plurality of components and the second subset of the first plurality of components.

Abstract: A faceplate of a showerhead has a bottom side that faces a plasma generation region and a top side that faces a plenum into which a process gas is supplied during operation of a substrate processing system. The faceplate includes apertures formed through the bottom side and openings formed through the top side. Each of the apertures is formed to extend through a portion of an overall thickness of the faceplate to intersect with at least one of the openings to form a corresponding flow path for process gas through the faceplate. Each of the apertures has a cross-section that has a hollow cathode discharge suppression dimension in at least one direction. Each of the openings has a cross-section that has a smallest cross-sectional dimension that is greater than the hollow cathode discharge suppression dimension.

Abstract: Flow batteries can include a first half-cell containing a first aqueous electrolyte solution, a second half-cell containing a second aqueous electrolyte solution, and a separator disposed between the first half-cell and the second half-cell, The first aqueous electrolyte solution contains a first redox-active material, and the second aqueous electrolyte solution contains a second redox-active material. At least one of the first redox-active material and the second redox-active material is a nitroxide compound or a salt thereof. Particular nitroxide compounds can include a doubly bonded oxygen contained in a ring bearing the nitroxide group, a doubly bonded oxygen appended to a ring bearing the nitroxide group, sulfate or phosphate groups appended to a ring bearing the nitroxide group, various heterocyclic rings bearing the nitroxide group, or acyclic nitroxide compounds.

Abstract: The disclosure includes a ski and ski pole carrying device that in many embodiments comprises two ski ties and lanyard. A ski pole strap with the proximal end coupled to a ski sleeve forms the ski tie. The ski ties may leave enough space between the sheaths and the bases to allow a portion of the skis' tips and tails to be slideably received by the ski tie as to secure the skis together. The ski ties may be arranged and configured for the skis' bases to be facing the same direction or in opposite directions. In some embodiments, the ski pole straps are a double sided hook and loop fastener arranged and configured to securely wrap around the respective ski tie and a pair of ski poles. The lanyard may be used in conjunction with the ski ties or independently to aid in carrying the skis and ski poles.

Abstract: A system for processing optical fiber includes a draw furnace, a fiber conveyance pathway extending between an upstream end positioned at the draw furnace and a downstream end positioned opposite the upstream end, where optical fiber is conveyed along the fiber conveyance pathway from the upstream end to the downstream end in a fiber conveyance direction, a muffle in communication with the draw furnace and positioned downstream of the draw furnace, a second cooling device annularly surrounding the fiber conveyance pathway downstream from the draw furnace, the second cooling device including one or more second cooling device heating elements and a first cooling device positioned between the draw furnace and the second cooling device, wherein the first cooling device directs a fluid to contact the optical fiber.

Abstract: A design for the electrical infrastructure of a data center enables two different configurations to be utilized, including a distributed, redundant configuration that provides higher reliability and a non-redundant configuration that provides higher capacity. In the distributed, redundant configuration, each server in the data center draws power from at least two different power supply systems. This enables load shifting when a power supply system becomes unavailable, which can have the effect of increasing server reliability. In the non-redundant configuration, each server in the data center draws power from only one power supply system. Load shifting is not utilized in the non-redundant configuration, which eliminates the need to maintain reserve capacity and thereby increases capacity. Advantageously, it is possible to switch between these two configurations without making any internal changes to the data center other than modifying connections between sets of server racks and power buses.

Abstract: Embodiments described herein describe a drug delivery device. The device includes a medicament container, a compressed gas container, an outlet, and a double-sided needle located within the housing. When a user presses an actuation button, the compressed air container is moved towards the medicament container and towards a proximal end of the double-sided needle. The double-sided needle pierces both the compressed gas container and the medicament container, opening fluid flow communication between the two containers, and causing medicament to be expelled out of the medicament container.