Patents by Inventor Scott Trzaska

Scott Trzaska has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline and salt forms of PPAR agonist compounds
    Patent number: 11912681
    Abstract: This disclosure relates to salt forms of compounds capable of activating PPAR? for use in drug substance and drug product development, and related compositions and methods.
    Type: Grant
    Filed: December 16, 2022
    Date of Patent: February 27, 2024
    Assignee: Mitobridge, Inc.
    Inventors: Bharat Lagu, Scott Trzaska
  • CRYSTALLINE AND SALT FORMS OF PPAR AGONIST COMPOUNDS
    Publication number: 20230257360
    Abstract: This disclosure relates to salt forms of compounds capable of activating PPAR? for use in drug substance and drug product development, and related compositions and methods.
    Type: Application
    Filed: December 16, 2022
    Publication date: August 17, 2023
    Inventors: Bharat Lagu, Scott Trzaska
  • Crystalline and salt forms of PPAR agonist compounds
    Patent number: 11530192
    Abstract: This disclosure relates to salt forms of compounds capable of activating PPAR? for use in drug substance and drug product development, and related compositions and methods.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: December 20, 2022
    Assignee: Mitobridge, Inc.
    Inventors: Bharat Lagu, Scott Trzaska
  • METHODS OF TREATING ACUTE KIDNEY INJURY
    Publication number: 20210283116
    Abstract: The present invention is directed to methods of treating a human patient with acute kidney injury.
    Type: Application
    Filed: October 5, 2017
    Publication date: September 16, 2021
    Applicants: Mitobridge, Inc., Mitobridge, Inc.
    Inventors: Bharat Lagu, Michael Patane, Effie Tozzo, Scott Trzaska
  • POLYMORPHS OF 5-({[2-AMINO-3-(4-CARBAMOYL-2,6-DIMETHYL-PHENYL)-PROPIONYL]-[1-(4-PHENYL-1H-IMIDAZOL-2-YL)-ETHYL]-AMINO}-METHYL)-2-METHOXY-BENZOIC ACID
    Publication number: 20210251964
    Abstract: The present invention relates to novel crystalline Forms D, E and F of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid, methods of preparing the same and their pharmaceutical compositions for use in treating opioid receptor mediated diseases.
    Type: Application
    Filed: August 19, 2019
    Publication date: August 19, 2021
    Inventors: Graham Lawton, Lia Faherty, Scott Trzaska
  • CRYSTALLINE AND SALT FORMS OF PPAR AGONIST COMPOUNDS
    Publication number: 20210171494
    Abstract: This disclosure relates to salt forms of compounds capable of activating PPAR? for use in drug substance and drug product development, and related compositions and methods.
    Type: Application
    Filed: February 19, 2021
    Publication date: June 10, 2021
    Inventors: Bharat Lagu, Scott Trzaska
  • Crystalline and salt forms of PPAR agonist compounds
    Patent number: 10927094
    Abstract: This disclosure relates to salt forms of compounds capable of activating PPAR? for use in drug substance and drug product development, and related compositions and methods.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: February 23, 2021
    Assignee: Mitobridge, Inc.
    Inventors: Bharat Lagu, Scott Trzaska
  • CRYSTALLINE AND SALT FORMS OF PPAR AGONIST COMPOUNDS
    Publication number: 20200181108
    Abstract: This disclosure relates to salt forms of compounds capable of activating PPAR? for use in drug substance and drug product development, and related compositions and methods.
    Type: Application
    Filed: October 5, 2017
    Publication date: June 11, 2020
    Inventors: Bharat Lagu, Scott Trzaska
  • Crystalline forms of a BACE inhibitor, compositions, and their use
    Patent number: 10035796
    Abstract: The present invention provides a novel synthesis of verubecestat, and two novel crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an A? pathology and/or a symptom or symptoms thereof. Non-limiting examples of such A? pathologies, including Alzheimer's disease, are disclosed herein.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: July 31, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Irina Kazakevich, Scott Trzaska, Tao Feng
  • Crystalline forms of a BACE inhibitor, compositions, and their use
    Patent number: 10017505
    Abstract: The present invention provides four crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an A? pathology and/or a symptom or symptoms thereof. Non-limiting examples of such A? pathologies, including Alzheimer's disease, are disclosed herein.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: July 10, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Scott Trzaska, Zachary E. Dance, Yong Liu, Richard John Varsolona, Gregory York
  • NOVEL CRYSTALLINE FORMS OF A BACE INHIBITOR, COMPOSITIONS, AND THEIR USE
    Publication number: 20170233383
    Abstract: The present invention provides four crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an A? pathology and/or a symptom or symptoms thereof. Non-limiting examples of such A? pathologies, including Alzheimer's disease, are disclosed herein.
    Type: Application
    Filed: September 25, 2015
    Publication date: August 17, 2017
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Scott Trzaska, Zachary E. Dance, Yong Liu, Richard John Varsolona, Gregory York
  • NOVEL CRYSTALLINE FORMS OF A BACE INHIBITOR, COMPOSITIONS, AND THEIR USE
    Publication number: 20170226098
    Abstract: The present invention provides a novel synthesis of verubecestat, and two novel crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an A? pathology and/or a symptom or symptoms thereof. Non-limiting examples of such A? pathologies, including Alzheimer's disease, are disclosed herein.
    Type: Application
    Filed: August 10, 2015
    Publication date: August 10, 2017
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Irina Kazakevich, Scott Trzaska, Tao Feng
  • Co-crystal of the PAR-1 receptor antagonists vorapaxar and aspirin
    Patent number: 9604971
    Abstract: This invention relates to a co-crystal of vorapaxar and aspirin. The inventive co-crystal antagonizes the PAR-1 receptor. This invention also provides for pharmaceutical compositions comprising the inventive co-crystal as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by antagonizing the PAR-1 receptor.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: March 28, 2017
    Assignee: ARALEZ PHARMACEUTICALS TRADING DAC
    Inventors: Scott Trzaska, Alicia V. Duran-Capece, Matthew Lamm
  • CO-CRYSTAL OF THE PAR-1 RECEPTOR ANTAGONISTS VORAPAXAR AND ASPRIN
    Publication number: 20160159779
    Abstract: This invention relates to a co-crystal of vorapaxar and aspirin. The inventive co-crystal antagonizes the PAR-1 receptor. This invention also provides for pharmaceutical compositions comprising the inventive co-crystal as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by antagonizing the PAR-1 receptor.
    Type: Application
    Filed: July 17, 2014
    Publication date: June 9, 2016
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Scott Trzaska, Alicia V. Duran-Capece, Matthew Lamm
  • Maleate, tosylate, fumarate and oxalate salts of 5-(1-(S)-amino-2-hydroxyethyl)-N-[(2,4-difluorophenyl)-methy]-2-[8-methoxy-2-(triflouromethy)-5-quinoline]-4-oxazolecarboxamide and preparation process therefore
    Patent number: 7956189
    Abstract: Disclosed are maleate, tosylate, fumarate, and oxalate salts of the compound 5-(1(S)-Amino-2-Hydroxyethyl)-N-[(2,4-Difluorophenyl)-Methyl]-2-[8-Methoxy-2-(Trifluoromethyl)-5-Quinoline]-4-Oxazolecarboxamide, represented by Formula I, and methods of preparing the same.
    Type: Grant
    Filed: August 10, 2007
    Date of Patent: June 7, 2011
    Assignee: Schering Corporation
    Inventors: Xiaoming Chen, Xiao Chen, Jianguo Yin, Xiaoyong Fu, David J. Blythin, Rongze Kuang, Ho-Jane Shue, Scott Trzaska, Chee-Wah Tang, Vincenzo Liotta, Zaher Shabani
  • Maleate, tosylate, fumarate and oxalate salts of 5-(1-(S)-amino-2-hydroxyethyl)-N-[(2,4-difluorophenyl)-methy]-2-[8-methoxy-2-(triflouromethy)-5-quinoline]-4-oxazolecarboxamide and preparation process therefore
    Publication number: 20080108818
    Abstract: Disclosed are maleate, tosylate, fumarate, and oxalate salts of the compound 5-(1(S)-Amino-2-Hydroxyethyl)-N-[(2,4-Difluorophenyl)-Methyl]-2-[8-Methoxy-2-(Trifluoromethyl)-5-Quinoline]-4-Oxazolecarboxamide, represented by Formula I, and methods of preparing the same.
    Type: Application
    Filed: August 10, 2007
    Publication date: May 8, 2008
    Inventors: Xiaoming Chen, Xiao Chen, Jianguo Yin, Xiaoyong Fu, David Blythin, Rongze Kuang, Ho-Jane Shue, Scott Trzaska, Chee-Wah Tang, Vincenzo Liotta, Zaher Shabani
  • XINAFOATE SALT OF A SUBSTITUTED 5-OXAZOL-2-YL-QUINOLINE COMPOUND
    Publication number: 20080027101
    Abstract: The present invention relates to the compound of the formula To methods of treating upper and lower obstructive airway diseases using said compound, to formulations comprising it, and to polymorphs and processes of synthesis of the polymorphic forms.
    Type: Application
    Filed: July 10, 2007
    Publication date: January 31, 2008
    Inventors: Pauline Ting, Joe Lee, Kung-I Feng, Michael Reeder, Scott Trzaska, Man Zhu, Chen Mao, Dimitar Filipov, Dimitrios Zarkadas