Patents by Inventor Scott Vafai

Scott Vafai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds, compositions and methods for making the same
    Patent number: 10583119
    Abstract: The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: March 10, 2020
    Assignee: Signum Biosciences, Inc.
    Inventors: Scott Vafai, Michael Voronkov, Maxwell Stock, Jeffry B. Stock, Seung-Yub Lee, Zhu Li, Haoming Gu
  • COMPOUNDS, COMPOSITIONS AND METHODS FOR MAKING THE SAME
    Publication number: 20170266161
    Abstract: The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.
    Type: Application
    Filed: November 8, 2016
    Publication date: September 21, 2017
    Applicant: Signum Biosciences, Inc.
    Inventors: SCOTT VAFAI, Michael Voronkov, Maxwell Stock, Jeffry B. Stock, Seung-Yub Lee, Zhu Li, Haoming Gu
  • Compounds, compositions and methods for making the same
    Patent number: 9486441
    Abstract: The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.
    Type: Grant
    Filed: April 21, 2009
    Date of Patent: November 8, 2016
    Assignee: SIGNUM BIOSCIENCES, INC.
    Inventors: Scott Vafai, Michael Voronkov, Maxwell Stock, Jeffry B. Stock, Seung-Yub Lee, Zhu Li, Haoming Gu
  • Method of identifying modulators of PP2A methylase
    Patent number: 7794965
    Abstract: The invention relates to methylated proteins that control protein phosphorylation, particularly phosphoesterases, such as PP2A. It relates to screening methods for determining agents that affect methylation of these proteins and thus also modulate the level of phosphorylation of phosphoproteins. It relates as well to the agents and to compositions comprising the agents. In a particular aspect in this regard the invention relates to agents that alter PP2A methylation and that thereby affect phosphorylation of phosphoproteins that play an important role in health or disease, such as the tau protein which is implicated in the etiology of Alzheimer's Disease. The invention further relates to diagnostic methods based on protein methylation levels, to compositions comprising agents for affecting methylation of proteins and for controlling the phosphate complement of phosphoproteins.
    Type: Grant
    Filed: March 13, 2003
    Date of Patent: September 14, 2010
    Assignees: Signum Biosciences, Inc., The Trustees of Princeton University
    Inventors: Gregory Stock, Jeffry B. Stock, Maxwell Stock, Scott Vafai
  • Compounds, Compositions and Methods for Making the Same
    Publication number: 20090264496
    Abstract: The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.
    Type: Application
    Filed: April 21, 2009
    Publication date: October 22, 2009
    Inventors: Scott Vafai, Michael Voronkov, Maxwell Stock, Jeffry B. Stock, Seung-Yub Lee, Zhu Li, Haoming Gu
  • Modulation of protein methylation and phosphoprotein phosphate
    Publication number: 20070031909
    Abstract: The invention relates to methylated proteins that control protein phosphorylation, particularly phosphoesterases, such as PP2A. It relates to screening methods for determining agents that affect methylation of these proteins and thus also modulate the level of phosphorylation of phosphoproteins. It relates as well to the agents and to compositions comprising the agents. In a particular aspect in this regard the invention relates to agents that alter PP2A methylation and that thereby affect phosphorylation of phosphoproteins that play an important role in health or disease, such as the tau protein which is implicated in the etiology of Alzheimer's Disease. The invention further relates to diagnostic methods based on protein methylation levels, to compositions comprising agents for affecting methylation of proteins and for controlling the phosphate complement of phosphoproteins.
    Type: Application
    Filed: March 13, 2003
    Publication date: February 8, 2007
    Inventors: Gregory Stock, Jeffry Stock, Maxwell Stock, Scott Vafai