Patents by Inventor Scott W. Smith

Scott W. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTALLINE FORM OF CYCLOSPORIN A, METHODS OF PREPARATION, AND METHODS FOR USE THEREOF
    Publication number: 20210269484
    Abstract: The present invention relates generally to crystalline forms of cyclosporin A and particularly to a newly identified form of cyclosporin A. The invention further relates to methods for its preparation and to methods for treating certain ocular disorders.
    Type: Application
    Filed: January 13, 2021
    Publication date: September 2, 2021
    Inventors: Anuradha V. Gore, Thomas K. Karami, Ke Wu, Richard S. Graham, Scott W. Smith
  • Tromethamine salt of bimatoprost acid in crystalline form 1, methods for preparation, and methods for use thereof
    Patent number: 10273206
    Abstract: The present invention provides tromethamine salt of (Z)-7-[3,5-Dihydroxy-2-((E)-3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline Form 1 and amorphous form. This compound is may also be referred to as “tromethamine salt of bimatoprost acid.” The invention crystalline form is useful for solid ocular implant or topical formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: April 30, 2019
    Assignee: ALLERGAN, INC.
    Inventors: Thomas K. Karami, Scott W. Smith, Fiona Dubas-Fisher, Adrian St. Clair Brown
  • CYCLOSPORIN A FORM 2 AND METHOD OF MAKING SAME
    Publication number: 20180312543
    Abstract: Disclosed herein are methods of making cyclosporin A Form 2.
    Type: Application
    Filed: July 6, 2018
    Publication date: November 1, 2018
    Inventors: Ke Wu, Scott W. Smith
  • Polymorphic forms of a steroid-like compound and methods for the preparation and use thereof
    Patent number: 10065984
    Abstract: Provided herein are multiple solid forms of a defined steroid-like compound, and methods for the preparation and use thereof. In one aspect, there is provided a crystalline form of said steroid-like compound, and methods for the preparation and use thereof. In another aspect, there is provided a substantially amorphous form of said steroid-like compound, and methods for the preparation and use thereof. In yet another aspect, there are provided compositions containing compounds according to the present invention. In certain aspects, such compositions are suitable for delivery of active agents according to the present invention to a subject in need thereof. In another aspect of the invention, there are provided methods for the treatment of a variety of indications, including glaucoma, ocular hypertension, and the like. In still another aspect of the present invention, there are provided kits containing compounds according to the present invention and/or compositions containing same.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: September 4, 2018
    Assignee: ALLERGAN, INC.
    Inventors: Shaoxin Feng, Scott W. Smith, Olivier M. G. Lambert, Suzanne M. Buttar
  • Cyclosporin a form 2 and method of making same
    Patent number: 10017541
    Abstract: Disclosed herein are methods of making cyclosporin A Form 2.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: July 10, 2018
    Assignee: Allergan, Inc.
    Inventors: Ke Wu, Scott W. Smith
  • Crystalline forms of bimatoprost acid, methods for preparation, and methods for use thereof
    Patent number: 9855232
    Abstract: The invention provides new crystalline forms of 7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid. This compound is commonly referred to as “bimatoprost acid.” The novel crystalline forms are designated forms I, II, and III. The invention crystalline forms are useful for solid ocular implant formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension. In addition, invention crystalline forms are useful for solid or semisolid dosage formulations used to treat ocular hypertension.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: January 2, 2018
    Assignee: ALLERGAN, INC.
    Inventors: Ke Wu, Shaoxin Feng, Thomas K. Karami, Scott W. Smith
  • CYCLOSPORIN A FORM 2 AND METHOD OF MAKING SAME
    Publication number: 20160272681
    Abstract: Disclosed herein are methods of making cyclosporin A Form 2.
    Type: Application
    Filed: May 26, 2016
    Publication date: September 22, 2016
    Inventors: Ke Wu, Scott W. Smith
  • Tromethamine salt of bimatoprost acid in crystalline form, methods for preparation, and methods for use thereof
    Patent number: 9447014
    Abstract: The present invention provides tromethamine salt of 7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline and amorphous form. This compound is may also be referred to as “tromethamine salt of bimatoprost acid.” The invention crystalline form is useful for solid ocular implant or topical formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: September 20, 2016
    Assignee: ALLERGAN, INC.
    Inventors: Thomas K. Karami, Scott W. Smith, Fiona Dubas-Fisher, Adrian St. Clair Brown
  • CRYSTALLINE FORMS OF BIMATOPROST ACID, METHODS FOR PREPARATION, AND METHODS FOR USE THEREOF
    Publication number: 20160175269
    Abstract: The invention provides new crystalline forms of 7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid. This compound is commonly referred to as “bimatoprost acid.” The novel crystalline forms are designated forms I, II, and III. The invention crystalline forms are useful for solid ocular implant formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension. In addition, invention crystalline forms are useful for solid or semisolid dosage formulations used to treat ocular hypertension.
    Type: Application
    Filed: July 17, 2015
    Publication date: June 23, 2016
    Inventors: Ke Wu, Shaoxin Feng, Thomas K. Karami, Scott W. Smith
  • Cyclosporin A form 2 and method of making same
    Patent number: 9352014
    Abstract: Disclosed herein are methods of making cyclosporin A Form 2.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: May 31, 2016
    Assignee: Allergan, Inc.
    Inventors: Ke Wu, Scott W. Smith
  • Process for rapid identification and preparation of crystalline forms
    Patent number: 9321717
    Abstract: Disclosed is a method of rapid identification and preparation of a crystalline form of an organic compound by using sub-gram level of said organic compound, comprising the steps of temperature-cycled slurrying, cooling, antisolvent addition and solvent evaporation as the major crystallization steps.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: April 26, 2016
    Assignee: ALLERGAN, INC.
    Inventors: Ke Wu, Gyorgy F. Ambrus, Scott W. Smith
  • CRYSTALLINE FORM OF CYCLOSPORIN A, METHODS OF PREPARATION, AND METHODS FOR USE THEREOF
    Publication number: 20160083432
    Abstract: The present invention relates generally to crystalline forms of cyclosporin A and particularly to a newly identified form of cyclosporin A. The invention further relates to methods for its preparation and to methods for treating certain ocular disorders.
    Type: Application
    Filed: December 7, 2015
    Publication date: March 24, 2016
    Inventors: Anuradha V. Gore, Thomas K. Karami, Ke Wu, Richard S. Graham, Scott W. Smith
  • TROMETHAMINE SALT OF BIMATOPROST ACID IN CRYSTALLINE FORM 1, METHODS FOR PREPARATION, AND METHODS FOR USE THEREOF
    Publication number: 20150376125
    Abstract: The present invention provides tromethamine salt of (Z)-7-[3,5-Dihydroxy-2-((E)-3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline Form 1 and amorphous form. This compound is may also be referred to as “tromethamine salt of bimatoprost acid.” The invention crystalline form is useful for solid ocular implant or topical formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension.
    Type: Application
    Filed: June 27, 2014
    Publication date: December 31, 2015
    Inventors: Thomas K. Karami, Scott W. Smith, Fiona Dubas-Fisher, Adrian St.Clair Brown
  • Crystalline form of cyclosporine A, methods of preparation, and methods for use thereof
    Patent number: 9206228
    Abstract: The present invention relates generally to crystalline forms of cyclosporine A and particularly to a newly identified form of cyclosporine A. The invention further relates to methods for its preparation and to methods for treating certain ocular disorders.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: December 8, 2015
    Assignee: Allergan, Inc.
    Inventors: Anuradha V. Gore, Thomas K. Karami, Ke Wu, Richard S. Graham, Scott W. Smith
  • Crystalline forms of bimatoprost acid, methods for preparation, and methods for use thereof
    Patent number: 9120738
    Abstract: The invention provides new crystalline forms of 7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid. This compound is commonly referred to as “bimatoprost acid.” The novel crystalline forms are designated forms I, II, and III. The invention crystalline forms are useful for solid ocular implant formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension. In addition, invention crystalline forms are useful for solid or semisolid dosage formulations used to treat ocular hypertension.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: September 1, 2015
    Assignee: Allergan, Inc.
    Inventors: Ke Wu, Shaoxin Feng, Thomas K. Karami, Scott W. Smith
  • Structures utilizing phase change for heat management applications
    Patent number: 9074822
    Abstract: An article is described that comprises a reticulated foam structure comprising a first ceramic or metal composition, and a second ceramic or metal composition disposed within the reticulated foam structure. The article may be compressed and sintered to form a monolith that can be used for mange heat by consuming heat energy through a phase change of one of the compositions.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: July 7, 2015
    Assignee: Lockheed Martin Corporation
    Inventors: Gautham Ramachandran, Scott W. Smith, Sanjay Prasad
  • Multiphase eutectic ceramic coatings
    Patent number: 9061947
    Abstract: Articles are described that include a substrate having thereon a coating that has two or more non-oxide compounds. A first one of the two or more non-oxide compounds is a non-oxide ceramic compound, and the two or more non-oxide compounds are present in relative amounts with respect to each other to form a eutectic composition mixture. The coating includes at least two discrete phases arranged in an interpenetrating three-dimensional microstructure.
    Type: Grant
    Filed: November 2, 2010
    Date of Patent: June 23, 2015
    Assignee: Lockheed Martin Corporation
    Inventors: Gautham Ramachandran, Sanjay Prasad, Scott W. Smith
  • POLYMORPHIC FORMS OF A STEROID-LIKE COMPOUND AND METHODS FOR THE PREPARATION AND USE THEREOF
    Publication number: 20150166597
    Abstract: Provided herein are multiple solid forms of a defined steroid-like compound, and methods for the preparation and use thereof. In one aspect, there is provided a crystalline form of said steroid-like compound, and methods for the preparation and use thereof. In another aspect, there is provided a substantially amorphous form of said steroid-like compound, and methods for the preparation and use thereof. In yet another aspect, there are provided compositions containing compounds according to the present invention. In certain aspects, such compositions are suitable for delivery of active agents according to the present invention to a subject in need thereof. In another aspect of the invention, there are provided methods for the treatment of a variety of indications, including glaucoma, ocular hypertension, and the like. In still another aspect of the present invention, there are provided kits containing compounds according to the present invention and/or compositions containing same.
    Type: Application
    Filed: December 12, 2014
    Publication date: June 18, 2015
    Inventors: Shaoxin Feng, Scott W. Smith, Olivier M.G. Lambert, Suzanne M. Buttar
  • CRYSTALLINE FORM OF CYCLOSPORINE A, METHODS OF PREPARATION, AND METHODS FOR USE THEREOF
    Publication number: 20140315827
    Abstract: The present invention relates generally to crystalline forms of cyclosporine A and particularly to a newly identified form of cyclosporine A. The invention further relates to methods for its preparation and to methods for treating certain ocular disorders.
    Type: Application
    Filed: July 2, 2014
    Publication date: October 23, 2014
    Inventors: Anuradha V. Gore, Thomas K. Karami, Ke Wu, Richard S. Graham, Scott W. Smith
  • CYCLOSPORIN A FORM 2 AND METHOD OF MAKING SAME
    Publication number: 20140303343
    Abstract: Disclosed herein are methods of making cyclosporin A Form 2.
    Type: Application
    Filed: June 19, 2014
    Publication date: October 9, 2014
    Inventors: Ke Wu, Scott W. Smith