Abstract: Microparticles containing a core of therapeutic protein and a cortex of a biocompatible and biodegradable polymer, and methods of making and using the microparticles are provided. The extended release of a therapeutic protein from the microparticles in a physiological solution is demonstrated over an extended period of time.

Abstract: The present invention describes a method for treating cancer comprising adoptive transfer of tumor antigen specific CD8+ T cells and an oncolytic virus vaccine targeting the same antigen.

Abstract: A microphone device generates a transmit audio stream via at least one microphone on the microphone device. The microphone device transmits the transmit audio stream to the computing device via a first wireless connection and ignores a receive audio stream received from the computing device via the first wireless connection. The speaker device obtains a set of connection parameters for the first wireless connection between the microphone device and the computing device, intercepts the receive audio stream transmitted using the first wireless connection from the computing device to the microphone device, and plays the receive audio stream on a speaker of the speaker device.

Abstract: An apparatus includes a network circuit to communicate with a network and a server on the network. The apparatus includes a wireless circuit to communicate with another wireless device. The apparatus includes control logic to determine that the other wireless device is within a given proximity of the apparatus, and to determine that the other wireless device is configured to perform automatic pairing. The control logic is further to, based on a determination that the other wireless device is within the given proximity of the apparatus and is configured to perform automatic pairing, access the server to determine whether to perform automatic pairing with the other wireless device. The control logic is to pair with the other wireless device without further input from a user of the apparatus.

Abstract: This disclosure provides novel anionic amphiphilic ?-hairpin peptides that self-assemble under appropriate conditions to form a reversible gel-sol hydrogel that can be used, for example, to readily deliver protein therapeutics and cells by injection to a target location in a subject.

Abstract: The present disclosure relates to a method for stimulating tumor antigen-specific immune responses comprising cancer vaccination involving the blockade or inhibition of interferon signaling. In particular, the method comprises administering an inhibitor of interferon signaling and a cancer vaccine comprising a tumor antigen, wherein the inhibitor of interferon signaling is administered before the cancer vaccine.

Abstract: A microphone device generates a transmit audio stream via at least one microphone on the microphone device. The microphone device transmits the transmit audio stream to the computing device via a first wireless connection and ignores a receive audio stream received from the computing device via the first wireless connection. The speaker device obtains a set of connection parameters for the first wireless connection between the microphone device and the computing device, intercepts the receive audio stream transmitted using the first wireless connection from the computing device to the microphone device, and plays the receive audio stream on a speaker of the speaker device.

Abstract: Microparticles containing a core of therapeutic protein and a cortex of a biocompatible and biodegradable polymer, and methods of making and using the microparticles are provided. The extended release of a therapeutic protein from the microparticles in a physiological solution is demonstrated over an extended period of time.

Abstract: An apparatus includes a network circuit to communicate with a network and a server on the network. The apparatus includes a wireless circuit to communicate with another wireless device. The apparatus includes control logic to determine that the other wireless device is within a given proximity of the apparatus, and to determine that the other wireless device is configured to perform automatic pairing. The control logic is further to, based on a determination that the other wireless device is within the given proximity of the apparatus and is configured to perform automatic pairing, access the server to determine whether to perform automatic pairing with the other wireless device. The control logic is to pair with the other wireless device without further input from a user of the apparatus.

Abstract: A connection base includes a first connection interface for connecting to and receiving an audio stream from a first endpoint, and a second connection interface for connecting to and transmitting the audio stream to a second endpoint. The connection base further includes an inference processing unit (IPU), connected to the first connection interface and the second connection interface, the IPU configured to execute an inference algorithm on an audio stream to obtain an inference result. The connection base is configured to output the inference result.

Abstract: Microparticles containing a core of therapeutic protein and a cortex of a biocompatible and biodegradable polymer, and methods of making and using the microparticles are provided. The extended release of a therapeutic protein from the microparticles in a physiological solution is demonstrated over an extended period of time.

Abstract: Antibodies and antigen binding fragments that specifically bind to IL-7R? are disclosed. Nucleic acids encoding the antibodies and antigen binding fragments, and vectors including the nucleic acid molecules are also provided. Methods for detecting a ca cancer or a cell that expresses IL-7R? using the antibodies and antigen binding fragments are disclosed, as is the use of the antibodies and antigen binding fragments to prevent and/or treat a subject with a cancer that expresses IL-7R?, such as acute lymphoblastic leukemia.

Abstract: The present invention describes a method for treating cancer comprising adoptive transfer of tumor antigen specific CD8+ T cells and an oncolytic virus vaccine targeting the same antigen.

Abstract: Antibodies and antigen binding fragments that specifically bind to IL-7R? are disclosed. Nucleic acids encoding the antibodies and antigen binding fragments, and vectors including the nucleic acid molecules are also provided. Methods for detecting a ca cancer or a cell that expresses IL-7R? using the antibodies and antigen binding fragments are disclosed, as is the use of the antibodies and antigen binding fragments to prevent and/or treat a subject with a cancer that expresses IL-7R?, such as acute lymphoblastic leukemia.

Abstract: The present invention describes a method for treating cancer comprising adoptive transfer of tumor antigen specific CD8+ T cells and an oncolytic virus vaccine targeting the same antigen.

Abstract: The present invention provides pharmaceutical formulations comprising a human antibody that specifically binds to human nerve growth factor (hNGF). The formulations may contain, in addition to an anti-hNGF antibody, at least one non-ionic surfactant, at least one sugar, and acetate. The pharmaceutical formulations of the present invention exhibit a substantial degree of antibody stability after storage for several months.

Abstract: This disclosure provides novel anionic amphiphilic ?-hairpin peptides that self-assemble under appropriate conditions to form a reversible gel-sol hydrogel that can be used, for example, to readily deliver protein therapeutics and cells by injection to a target location in a subject.

Abstract: The present invention describes a method for treating cancer comprising adoptive transfer of tumor antigen specific CD8+ T cells and an oncolytic virus vaccine targeting the same antigen.

Abstract: Antibodies and antigen binding fragments that specifically bind to IL-7R? are disclosed. Nucleic acids encoding the antibodies and antigen binding fragments, and vectors including the nucleic acid molecules are also provided. Methods for detecting a ca cancer or a cell that expresses IL-7R? using the antibodies and antigen binding fragments are disclosed, as is the use of the antibodies and antigen binding fragments to prevent and/or treat a subject with a cancer that expresses IL-7R?, such as acute lymphoblastic leukemia.

Abstract: The present disclosure provides novel bone matrix (BM) materials, and methods for preparation and use of the demineralized bone matrix materials and compositions therefrom. The methods of preparation include the use of a closed-vessel demineralization system, as well as simple, easily reproducible process steps, and significantly shortened times for demineralization. These novel BM materials do not require the inclusion of carriers and/or delivery agents, or the addition of binders, and can be made in various forms, including a clay, putty, crush, powder, or gel. The novel BM compositions and methods disclosed herein may, illustratively, have applications in the medical field, such as in surgical bone graft applications, in the repair and/or regeneration of bone and bone-related tissue, and the like.