Abstract: The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and thus can be usefully used in the treatment of lung cancer.

Abstract: A vacuum blender having a foreign body catching member mounted thereon, the foreign body catching member disposed outside a container cover such that one end is communicatably coupled to a discharge hole formed in the container cover, and the other end is communicatably coupled to a communication path enabling a vacuum pump to communicate with the container cover. When the vacuum pump is operated in a state where the two ends of the foreign body catching member are communicating with the discharge hole and the communication path, respectively, air inside a crushing container is discharged to the outside by passing through the vacuum pump via the discharge hole, the foreign body catching member, and the communication path, and, by means of moving relative to the container cover, the foreign body catching member disposed outside the container cover has the one end communicate with or be blocked from the discharge hole.

Abstract: The present invention relates to a heteroaryl derivative compound and a use thereof. Since the heteroaryl derivative of the present invention exhibits excellent inhibitory activity against EGFR, the heteroaryl derivative can be usefully used as a therapeutic agent for EGFR-associated diseases.

Abstract: Disclosed are a hybrid electric vehicle and an engine control method therefor that are capable of reducing entry of an engine into a full-load drive mode. The method includes determining whether the extent of depression of an accelerator pedal (APS) may be equal to or greater than a reference value set as a condition for entry of an engine into a full-load drive mode, determining a part-load torque corresponding to the maximum torque in a part-load drive mode of the engine and a motor torque corresponding to the maximum torque of a motor when the extent of depression of the accelerator pedal may be equal to or greater than the reference value, comparing the sum of the part-load torque and the motor torque with a driver demand torque, and controlling the engine in the full-load drive mode or the part-load drive mode depending on a result of the comparing.

Abstract: A method of compensating fuel for each cylinder of an engine during purging may include, compensating a fuel injection time for each cylinder depending on an amount of intake air for each cylinder, an injection pressure of the injector, and an internal pressure of a combustion chamber of the engine; pressurizing a vaporized gas adsorbed into a canister and injecting the pressurized vaporized gas into the intake pipe by operating an active purge pump; and estimating an amount of vaporized gas reaching each combustion chamber and converting the fuel injection time depending on the estimated amount of vaporized gas.

Abstract: An active purge system may include: a canister to collect therein an evaporation gas evaporated from a fuel tank; a purge line to connect the canister to an intake pipe; a purge pump to pressurize the evaporation gas to allow the evaporation gas to move from the canister to the intake pipe; a purge valve installed on the purge line to be located between the purge pump and the intake pipe; and an engine connected to the intake pipe. In particular, the engine includes an injector installed on a cylinder head, an intake valve, and an exhaust valve.

Abstract: A method of compensating fuel for each cylinder of an engine during purging may include, compensating a fuel injection time for each cylinder depending on an amount of intake air for each cylinder, an injection pressure of the injector, and an internal pressure of a combustion chamber of the engine; pressurizing a vaporized gas adsorbed into a canister and injecting the pressurized vaporized gas into the intake pipe by operating an active purge pump; and estimating an amount of vaporized gas reaching each combustion chamber and converting the fuel injection time depending on the estimated amount of vaporized gas.

Abstract: An active purge system may include: a canister to collect therein an evaporation gas evaporated from a fuel tank; a purge line to connect the canister to an intake pipe; a purge pump to pressurize the evaporation gas to allow the evaporation gas to move from the canister to the intake pipe; a purge valve installed on the purge line to be located between the purge pump and the intake pipe; and an engine connected to the intake pipe. In particular, the engine includes an injector installed on a cylinder head, an intake valve, and an exhaust valve.

Abstract: A method for controlling an engine having a continuous variable valve duration (CVVD) apparatus is provided. The method includes: correcting a torque required by a driver; transmitting, by a hybrid control unit (HCU), a start signal to an engine control unit (ECU) when the corrected torque satisfies conditions required to drive the engine; determining a target CVVD value for operation of an intake CVVD apparatus corresponding to the corrected torque; determining a target current value corresponding to the target CVVD value; and changing the target CVVD value to a synchronizing CVVD value when a current state of the engine is in a cranking interval, wherein the synchronizing CVVD value is configured to synchronize starting revolutions per minute (RPM) of the engine with RPM of an automatic transmission or RPM of a motor generator.

Abstract: A method for controlling an engine having a continuous variable valve duration (CVVD) apparatus is provided. The method includes: correcting a torque required by a driver; transmitting, by a hybrid control unit (HCU), a start signal to an engine control unit (ECU) when the corrected torque satisfies conditions required to drive the engine; determining a target CVVD value for operation of an intake CVVD apparatus corresponding to the corrected torque; determining a target current value corresponding to the target CVVD value; and changing the target CVVD value to a synchronizing CVVD value when a current state of the engine is in a cranking interval, wherein the synchronizing CVVD value is configured to synchronize starting revolutions per minute (RPM) of the engine with RPM of an automatic transmission or RPM of a motor generator.

Abstract: A method for controlling an engine variable valve timing of a hybrid electric vehicle, may include providing a cam position setting table of a fuel efficiency prioritized intake/exhaust cam control mode, and a cam position setting table of a normal intake/exhaust cam control mode, the cam position setting table of the fuel efficiency prioritized intake/exhaust cam control mode being differentiated from the cam position setting table of the normal intake/exhaust cam control mode; selecting one of the fuel efficiency prioritized intake/exhaust cam control mode and the normal intake/exhaust cam control mode by a canister loading amount and whether or not diagnosis of an intake cam and diagnosis of an exhaust cam are completed; and determining position control values of the intake and exhaust cams by using the cam position setting table and then controlling positions of the intake cam and the exhaust cam by the determined position control values.

Abstract: A method for preventing over discharge of a battery includes steps of: detecting a gradient of a road on which a vehicle is running by a controller, when a battery is discharged under a state that an engine of the running vehicle is operated, detecting a clutch driving state of an engine clutch, which connects or disconnects the engine and an electric motor, after detecting the road gradient, detecting a SOC (State of Charge) of the battery after detecting the clutch driving state of the engine clutch, and carrying out a torque reserve control allowing more torque to be reserved in the engine, using a combination of the road gradient, the clutch driving state, and the battery SOC, such that the battery SOC is not lowered below a certain amount.

Abstract: A method for controlling an engine variable valve timing of a hybrid electric vehicle, may include providing a cam position setting table of a fuel efficiency prioritized intake/exhaust cam control mode, and a cam position setting table of a normal intake/exhaust cam control mode, the cam position setting table of the fuel efficiency prioritized intake/exhaust cam control mode being differentiated from the cam position setting table of the normal intake/exhaust cam control mode; selecting one of the fuel efficiency prioritized intake/exhaust cam control mode and the normal intake/exhaust cam control mode by a canister loading amount and whether or not diagnosis of an intake cam and diagnosis of an exhaust cam are completed; and determining position control values of the intake and exhaust cams by using the cam position setting table and then controlling positions of the intake cam and the exhaust cam by the determined position control values.

Abstract: A method for preventing over discharge of a battery includes steps of: detecting a gradient of a road on which a vehicle is running by a controller, when a battery is discharged under a state that an engine of the running vehicle is operated, detecting a clutch driving state of an engine clutch, which connects or disconnects the engine and an electric motor, after detecting the road gradient, detecting a SOC (State of Charge) of the battery after detecting the clutch driving state of the engine clutch, and carrying out a torque reserve control allowing more torque to be reserved in the engine, using a combination of the road gradient, the clutch driving state, and the battery SOC, such that the battery SOC is not lowered below a certain amount.

Abstract: A method for diagnosing a leak of a fuel system in a vehicle is provided. The method includes determining whether an engine is actuated and a vehicle is thus driven as a monitoring condition for diagnosing the leak of the fuel system and determining whether an additional monitoring condition for monitoring an outflow of the fuel system is satisfied in response to determining that the engine is actuated and the internal pressure of a fuel tank included in the fuel system is less than a target value. The additional monitoring condition is a condition of preventing misdiagnosis of the leak in the fuel system due to disturbance while the vehicle is driven.