Patents by Inventor Se-Hwan Paek
Se-Hwan Paek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220241702Abstract: The present invention relates to an affinity isolation system and method using a switch-like binding reaction. An affinity isolation system according to an embodiment of the present invention comprises: a ligand (10); a binder (20) to which the ligand (10) is reversibly bound and which structurally changes with the binding reaction thereof with the ligand (10); a recognition material (30) specifically binding to the structurally changed binder (20); an immobilizing member (40) having a surface onto which any one of the binding pair, the binder (20) and the recognition material (30), is immobilized; and a capturing material (50) conjugating with the other of the binding pair, the binder (20) and the recognition material (30), to form a conjugate (C) and specifically binding to the target (1) in a target subpopulation from a sample solution.Type: ApplicationFiled: January 10, 2020Publication date: August 4, 2022Applicant: SOL BIO CORPORATIONInventor: Se Hwan PAEK
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Patent number: 11154857Abstract: A single-channel, chemical-immunological hybrid biosensor is disclosed. According to an embodiment, the hybrid biosensor includes a reaction strip 100 in the form of a porous membrane through which a sample 1 moves by capillary action. the reaction strip 100 is in the form of a porous membrane through which the sample 1 moves by capillary action. Biomarkers in the sample 1 are independently detected based on a chemical reaction and binding reactions on the reaction strip 100.Type: GrantFiled: April 19, 2019Date of Patent: October 26, 2021Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUSInventor: Se-Hwan Paek
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Patent number: 10889794Abstract: The present invention relates to an apparatus that uses shadow images of cells to continuously measure cell activity at a high processing rate in order to provide cell activity and cell number results. According to one embodiment of the present invention, instead of a highly experienced examiner or technician using a microscope, ELISA reader, etc. having to collect various cell activity measurements and cell numbers, the collection of said information can be automated so as to reduce cost and largely reduce errors in measurements through the development of computer software coupled with hardware using low cost and compact optoelectronic components and simple image processing techniques.Type: GrantFiled: December 27, 2012Date of Patent: January 12, 2021Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUSInventors: Sung-Kyu Seo, Geon-Soo Jin, Un-Hwan Ha, Se-Hwan Paek, Seung-Pil Pack
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Patent number: 10866237Abstract: Disclosed is an ultrahigh-sensitivity two-dimensional chromatography-based biosensor, wherein cross-flow of high driving force across a narrow membrane is applied, thereby enabling the elimination of background noise, efficient supply of a large-sized polymeric or high-molecular-weight signal tracer, sequential material supply for increased reactivity, and simultaneous washing and signal generation when additional signal generation is required, as in an enzyme.Type: GrantFiled: January 26, 2017Date of Patent: December 15, 2020Assignee: Korea University Research and Business FoundationInventor: Se-Hwan Paek
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Patent number: 10799861Abstract: Disclosed is a biochemical-immunological hybrid biosensor. The biochemical-immunological hybrid biosensor includes a reaction strip in the form of a porous membrane through which a sample moves by capillary action. The reaction strip can simultaneously measure heterogeneous multiple biomarkers through both a biochemical analysis and an immunoassay in an independent manner based on membrane chromatography to diagnose a particular disease.Type: GrantFiled: November 22, 2017Date of Patent: October 13, 2020Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUSInventor: Se-Hwan Paek
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Publication number: 20190321818Abstract: A single-channel, chemical-immunological hybrid biosensor is disclosed. According to an embodiment, the hybrid biosensor includes a reaction strip 100 in the form of a porous membrane through which a sample 1 moves by capillary action. the reaction strip 100 is in the form of a porous membrane through which the sample 1 moves by capillary action. Biomarkers in the sample 1 are independently detected based on a chemical reaction and binding reactions on the reaction strip 100.Type: ApplicationFiled: April 19, 2019Publication date: October 24, 2019Inventor: Se-Hwan PAEK
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Patent number: 10191046Abstract: An immunobiosensor is disclosed. The immunobiosensor is based on a membrane lateral flow immuno-chromatographic assay (LF-ICA). The immunobiosensor includes: a metal binding protein 10 whose conformation changes upon reaction with a metal ion 1 in a sample; a sensing antibody 20 reacting with the conformationally changed metal binding protein 10 as an antigen; a signal substance 30 conjugated with the metal binding protein 10 or the sensing antibody 20 to form a signal conjugate 30a or 30b; a signal generator 40 reacting with the signal conjugate 30a or 30b to generate a reaction signal; and a reaction strip 50 in the form of a porous membrane adapted to move the sample and where the antigen-antibody reaction occurs and the reaction signal is generated. Also disclosed is a sensor system including the immunobiosensor.Type: GrantFiled: May 23, 2017Date of Patent: January 29, 2019Assignees: Se-Hwan Paek, KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATIONInventors: Se-Hwan Paek, Ji-Na Park, Sung-Ho Paek
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Patent number: 9983202Abstract: Disclosed is a method of synthesizing a polymeric fluorescent tracer for signal amplification, including (a) subjecting a streptavidin-fluorophore conjugate (SA-FL) and a spacer-attached biotin-conjugated antibody (b-Ab) to reaction at least two times; (b) treating a dual biotin oligomer spacer (db-oN); and (c) performing a homogenization process.Type: GrantFiled: January 23, 2017Date of Patent: May 29, 2018Assignee: Korea University Research and Business FoundationInventors: Se-Hwan Paek, Sung-Min Seo
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Publication number: 20180141041Abstract: Disclosed is a biochemical-immunological hybrid biosensor. The biochemical-immunological hybrid biosensor includes a reaction strip in the form of a porous membrane through which a sample moves by capillary action. The reaction strip can simultaneously measure heterogeneous multiple biomarkers through both a biochemical analysis and an immunoassay in an independent manner based on membrane chromatography to diagnose a particular disease.Type: ApplicationFiled: November 22, 2017Publication date: May 24, 2018Inventor: Se-Hwan PAEK
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Publication number: 20170336405Abstract: An immunobiosensor is disclosed. The immunobiosensor is based on a membrane lateral flow immuno-chromatographic assay (LF-ICA). The immunobiosensor includes: a metal binding protein 10 whose conformation changes upon reaction with a metal ion 1 in a sample; a sensing antibody 20 reacting with the conformationally changed metal binding protein 10 as an antigen; a signal substance 30 conjugated with the metal binding protein 10 or the sensing antibody 20 to form a signal conjugate 30a or 30b; a signal generator 40 reacting with the signal conjugate 30a or 30b to generate a reaction signal; and a reaction strip 50 in the form of a porous membrane adapted to move the sample and where the antigen-antibody reaction occurs and the reaction signal is generated. Also disclosed is a sensor system including the immunobiosensor.Type: ApplicationFiled: May 23, 2017Publication date: November 23, 2017Inventors: Se-Hwan Paek, Ji-Na Park, Sung-Ho Paek
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Publication number: 20170241962Abstract: Disclosed is an ultrahigh-sensitivity two-dimensional chromatography-based biosensor, wherein cross-flow of high driving force across a narrow membrane is applied, thereby enabling the elimination of background noise, efficient supply of a large-sized polymeric or high-molecular-weight signal tracer, sequential material supply for increased reactivity, and simultaneous washing and signal generation when additional signal generation is required, as in an enzyme.Type: ApplicationFiled: January 26, 2017Publication date: August 24, 2017Inventor: Se-hwan Paek
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Publication number: 20160348058Abstract: The present invention relates to an apparatus that uses shadow images of cells to continuously measure cell activity at a high processing rate in order to provide cell activity and cell number results. According to one embodiment of the present invention, instead of a highly experienced examiner or technician using a microscope, ELISA reader, etc. having to collect various cell activity measurements and cell numbers, the collection of said information can be automated so as to reduce cost and largely reduce errors in measurements through the development of computer software coupled with hardware using low cost and compact optoelectronic components and simple image processing techniques.Type: ApplicationFiled: August 11, 2016Publication date: December 1, 2016Inventors: Sung-Kyu SEO, Geon-Soo JIN, Un-Hwan HA, Se-Hwan PAEK, Seung-Pil PACK
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Publication number: 20150050684Abstract: The present invention relates to an apparatus that uses shadow images of cells to continuously measure cell activity at a high processing rate in order to provide cell activity and cell number results. According to one embodiment of the present invention, instead of a highly experienced examiner or technician using a microscope, ELISA reader, etc. having to collect various cell activity measurements and cell numbers, the collection of said information can be automated so as to reduce cost and largely reduce errors in measurements through the development of computer software coupled with hardware using low cost and compact optoelectronic components and simple image processing techniques.Type: ApplicationFiled: December 27, 2012Publication date: February 19, 2015Inventors: Sung-Kyu Seo, Geon-Soo Jin, Un-Hwan Ha, Se-Hwan Paek, Seung-Pil Pack
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Publication number: 20110097740Abstract: Provided is a real-time continuous detection device for detecting an analyte in a sample including: a sample inflow channel; a sample assay site; and a sample outflow channel, wherein the sample assay site includes a reversible capturing recognizing component and a sensor which detects a signal generated from a binding body of the analyte and the reversible capturing recognizing component. According to the real-time continuous detection device, it is possible to measure a change in concentration of the analyte in real time by continuously recycling the reversible capturing recognizing component. The real-time continuous detection device can be used to detect or assay living organism metabolites, a protein, a hormone, a nucleic acid, a cell, a food test material, an environment contaminant, national-defense chemical, biological and radiological test materials, or the like.Type: ApplicationFiled: June 12, 2009Publication date: April 28, 2011Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATIONInventors: Se Hwan Paek, Hyun-Kyu Cho
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Publication number: 20080019866Abstract: The present invention relates to a lab-on-a-chip version of biosensor for an on-the-spot analysis whose analytical performances were remarkably improved, by incorporating commercial membranes, traditionally used for rapid diagnostics, into microfluidic channels engraved on the surface of a plastic chip, as follows: 1) reduction of sample size; 2) realization of variable functions for total analysis; and 3) transfer of medium by capillary action without the assistance of an external force.Type: ApplicationFiled: December 1, 2005Publication date: January 24, 2008Inventors: Se-Hwan Paek, Joo-Eun Kim
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Patent number: 7300802Abstract: The present invention relates to a biosensor for point-of-care testing (POCT) whose detection sensitivity was remarkably improved by introducing to membrane strip chromatographic assay system a successive cross-flow procedure for immune reaction and enzymatic reaction.Type: GrantFiled: April 20, 2004Date of Patent: November 27, 2007Assignee: Biodigit Laboratories Corp.Inventors: Se Hwan Paek, Jung Hwan Cho, Ser Ka Kim
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Publication number: 20040214253Abstract: The present invention relates to a biosensor for point-of-care testing (POCT) whose detection sensitivity was remarkably improved by introducing to membrane strip chromatographic assay system a successive cross-flow procedure for immune reaction and enzymatic reaction.Type: ApplicationFiled: April 20, 2004Publication date: October 28, 2004Inventors: Se Hwan Paek, Jung Hwan Cho, Ser Ka Kim
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Patent number: 6478938Abstract: The present invention is directed to the development of a biosensor based on the immuno-chromatographic method that can provide an assay speed and convenience required for point-of-care (the doctor's office and emergency room) testing or home-version diagnosis. Though certain physical symptoms, such as pregnancy and ovulation, or bacterial infection may be identified by a qualitative analysis for the presence of indicating substances, most analytes for clinical investigation demand their concentrations known in specimens. Therefore, the inventors of the present invention have developed a novel biosensor by combining the immuno-chromatographic method and the electric conductivity detection technology so that on-site quantitative determination at the points of care or at home may be carried out.Type: GrantFiled: June 14, 2000Date of Patent: November 12, 2002Assignee: Bio Digit Laboratories CorporationInventors: Se-Hwan Paek, Joung-Hwan Cho