Patents by Inventor Se-In Chang

Se-In Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE
    Publication number: 20150056223
    Abstract: The present invention relates to a pharmaceutical composition for the prevention and treatment of non-alcoholic fatty liver disease (NAFLD), including a conjugate prepared by covalently linking an insulinotropic peptide, a non-peptidyl polymer and an immunoglobulin Fc region. The composition of the present invention maintains the in-vivo activity of the peptide at a relatively high level, and remarkably increases the blood half-life, thereby preventing triglyceride accumulation which is a typical feature of non-alcoholic fatty liver disease. Ultimately, it can be desirably employed for the prevention and treatment of non-alcoholic fatty liver disease.
    Type: Application
    Filed: March 8, 2013
    Publication date: February 26, 2015
    Applicant: HANMI SCIENCE CO., LTD
    Inventors: Se Young Lim, Sung Hee Park, Ryoung Ae Shin, In Young Choi, Se Chang Kwon
  • METHOD OF CULTURING E. COLI CELLS FOR HIGH DENSITY
    Publication number: 20150050692
    Abstract: Disclosed is a method of culturing E. coli cells for high density, comprising a cell growth step and an expression induction step by which a maximum of cell mass can be obtained with the concomitant maximum expression of a recombinant protein. E. coli transformed to produce a recombinant protein of interest can be grown at a high concentration using the culturing method of the present invention. Therefore, the method increases the productivity of cells as well as the production yield of the recombinant protein, and can be widely applied to the effective production of recombinant proteins.
    Type: Application
    Filed: March 12, 2013
    Publication date: February 19, 2015
    Applicant: HANMI SCIENCE CO., LTD.
    Inventors: Yong Ho Huh, Euh Lim Oh, Sung Youb Jung, Se Chang Kwon
  • Vector and expression cell line for mass production of recombinant protein and a process of producing recombinant protein using same
    Patent number: 8957196
    Abstract: Disclosed herein is an inducible high-expression cassette comprising a dihydrofolate reductase (DHFR) promoter from which GC-rich repeat sequences are partially or entirely removed, the cassette capable of more effectively improving a gene amplification system. Also disclosed are an expression vector comprising the inducible expression cassette and optionally a gene encoding a recombinant protein of interest, an animal cell line transformed with the expression vector, and a method of mass producing and purifying a recombinant protein by culturing the transformant. The present invention enables the shortening of the time required to establish a cell line producing a recombinant protein of interest at high levels using a low concentration of a DHFR inhibitor, thereby allowing more effective production of the recombinant protein.
    Type: Grant
    Filed: October 16, 2007
    Date of Patent: February 17, 2015
    Assignee: Hanmi Science Co., Ltd.
    Inventors: In Young Choi, Chang Hwan Kim, Hyun Ji Lee, Seong Hee Park, Se Chang Kwon, Gwan Sun Lee
  • IGG FC FRAGMENT FOR A DRUG CARRIER AND METHOD FOR THE PREPARATION THEREOF
    Publication number: 20150025228
    Abstract: Disclosed is an IgG Fc fragment useful as a drug carrier. A recombinant vector expressing the IgG Fc fragment, a transformant transformed with the recombinant vector, and a method of preparing an IgG Fc fragment are disclosed. When conjugated to a certain drug, the IgG Fc fragment improves the in vivo duration of action of the drug and minimizes the in vivo activity reduction of the drug.
    Type: Application
    Filed: July 9, 2014
    Publication date: January 22, 2015
    Applicant: HANMI SCIENCE CO., LTD.
    Inventors: Sung Youb JUNG, Jin Sun Kim, Geun Hee Yang, Se Chang Kwon, Gwan Sun Lee
  • WINDOW FOR DISPLAY DEVICE AND DISPLAY DEVICE INCLUDING THE WINDOW PANEL
    Publication number: 20140377520
    Abstract: Disclosed are a window for a display device including a window mother substrate for the display device; and a protective film disposed on the window mother substrate for the display device, wherein the protective film includes a multi-layer structure disposed on the window mother substrate for the display device, a first plastic substrate disposed on the multi-layer structure, and a second plastic substrate disposed on the first plastic substrate, and a display device including the same.
    Type: Application
    Filed: January 17, 2014
    Publication date: December 25, 2014
    Applicant: Samsung Display Co., Ltd.
    Inventor: Se-In CHANG
  • SITE-SPECIFIC GLP-2 CONJUGATE USING AN IMMUNOGLOBULIN FRAGMENT
    Publication number: 20140377290
    Abstract: The present invention relates to a glucagon-like peptide-2 (GLP-2) conjugate comprising native GLP-2 or its derivative and an immunoglobulin Fc fragment being covalently linked via a non-peptidyl polymer, wherein the native GLP-2 or its derivative has a thiol group introduced at its C-terminal end, and one end of the non-peptidyl polymer is linked to an amino acid residue of the GLP-2 other than the N-terminal amino group thereof; a method for preparing the GLP-2 conjugate; a pharmaceutical composition comprising the same; and a method for treating or preventing intestinal disease, intestinal injury, or gastrosia by using the same. Since the GLP-2 conjugate of the present invention has a remarkably increased binding affinity to a GLP-2 receptor, it shows a prolonged in vivo half-life and an improved in vivo durability and stability.
    Type: Application
    Filed: December 28, 2012
    Publication date: December 25, 2014
    Applicant: HANMI SCIENCE CO., LTD.
    Inventors: Seung Su Kim, Se Young Lim, Sung Youb Jung, Se Chang Kwon
  • IMMUNOGLOBULIN FC VARIANTS
    Publication number: 20140357843
    Abstract: The present invention relates to immunoglobulin Fc variants having an increased binding affinity for FcRn, which is characterized by including one or more amino acid modifications selected from the group consisting of 307S, 308F, 380S, 380A, 428L, 429K, 430S, 433K and 434S (this numbering is according to the EU index) in the constant region of a native immunoglobulin Fc fragment. Owing to the high binding affinity for FcRn, the immunoglobulin Fc variants according to the present invention show more prolonged in vivo half-life, and thus can be used for the preparation of a long-acting formulation of protein drugs.
    Type: Application
    Filed: December 28, 2012
    Publication date: December 4, 2014
    Applicant: HANMI SCIENCE CO., LTD
    Inventors: Euh Lim Oh, Yong Ho Huh, Sang Youn Hwang, In Young Choi, Sung Youb Jung, Se Chang Kwon
  • Method for preparing a site-specific physiologically active polypeptide conjugate
    Patent number: 8895281
    Abstract: The present invention provides a method for preparing a site-specific physiologically active polypeptide conjugate in a high yield by treating a physiologically active polypeptide with a non-peptidyl polymer in the presence of an alcohol at a specific pH, which can be desirably employed in the development of long acting formulations of various peptide drugs having high in-vivo activity and markedly prolonged in-blood half-life.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: November 25, 2014
    Assignee: Hanmi Science Co., Ltd
    Inventors: Dae Hae Song, Jae Hee Shin, Jae Min Lee, Young Kyung Park, Se Chang Kwon, Gwan Sun Lee
  • Display module
    Patent number: 8891039
    Abstract: A display module includes a display panel configured to display an image and a backlight. The backlight includes a light guide panel configured to guide light to the display panel, a light source element configured to supply light to the light guide panel, and a reflection sheet disposed over the light guide panel, wherein a chromaticity compensation layer is formed in the backlight unit. The chromaticity compensation layer formed in the backlight reduces yellowing.
    Type: Grant
    Filed: August 10, 2011
    Date of Patent: November 18, 2014
    Assignee: Samsung Display Co., Ltd.
    Inventor: Se-In Chang
  • METHOD FOR PREPARING PHYSIOLOGICALLY ACTIVE POLYPEPTIDE COMPLEX
    Publication number: 20140296475
    Abstract: A method for preparing a conjugate of a physiologically active polypeptide and a non-peptide polymer by linking physiologically active polypeptide with non-peptide polymer through a covalent bond using an organic solvent is provided. A method for preparing a physiologically active polypeptide complex by linking the conjugate with a carrier is provided. The complex shows improved in vivo duration and stability of the physiologically active polypeptide. The method can prepare the conjugate at a lower production cost, and the resulting conjugate shows an extension of in vivo activity at a relatively high level and significantly increase in the blood half-life.
    Type: Application
    Filed: November 2, 2012
    Publication date: October 2, 2014
    Applicant: HANMI SCIENCE CO., LTD
    Inventors: Dae Jin Kim, Myung Hyun Jang, Seung Su Kim, Jong Soo Lee, Jae Hyuk Choi, Se Chang Kwon
  • IgG Fc fragment for a drug carrier and method for the preparation thereof
    Patent number: 8846874
    Abstract: Disclosed is an IgG Fc fragment useful as a drug carrier. Also, the present invention discloses a recombinant vector expressing the IgG Fc fragment, a transformant transformed with the recombinant vector, and a method of preparing an IgG Fc fragment, comprising culturing the transformant. When conjugated to a certain drug, the IgG Fc fragment improves the in vivo duration of action of the drug and minimizes the in vivo activity reduction of the drug.
    Type: Grant
    Filed: November 13, 2004
    Date of Patent: September 30, 2014
    Assignee: Hanmi Science Co., Ltd
    Inventors: Sung Youb Jung, Jin Sun Kim, Geun Hee Yang, Se Chang Kwon, Gwan Sun Lee
  • BLOOD COAGULATION FACTOR VII AND VIIA DERIVATIVES, CONJUGATES AND COMPLEXES COMPRISING THE SAME, AND USE THEREOF
    Publication number: 20140271607
    Abstract: A blood coagulation factor VII derivative, a blood coagulation factor VIIa derivative, FacVII and FacVIIa conjugates are prepared by linking a polymer capable of extending the blood half-life to the derivative. FacVII and VIIa complexes each prepared by linking a carrier to the conjugate, genes encoding the FacVII and FacVIIa derivatives, expression vectors comprising the genes, transformants introduced with the expression vectors, a method for preparing the FacVII and FacVIIa derivatives using the transformants, a method for preparing the FacVIIa conjugate and complex, a FacVIIa complex prepared by the method, a pharmaceutical composition for the prevention or treatment of hemophilia comprising the derivative, conjugate, or complex as an active ingredient, and a pharmaceutical composition for blood coagulation comprising the derivative, conjugate, or complex as an active ingredient are described.
    Type: Application
    Filed: October 5, 2012
    Publication date: September 18, 2014
    Inventors: Dae Jin Kim, Byung Sun Lee, Sung Hwan Hong, Yong Ho Huh, Sung Youb Jung, Se Chang Kwon
  • Liquid formulations for long-acting erythropoietin conjugate
    Patent number: 8829163
    Abstract: Disclosed is a liquid formulation which allows long-acting EPO conjugates, that have improved in vivo duration and stability, to be stable when stored for a long period of time. It comprises a stabilizer composition characterized by buffer and mannitol. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting EPO conjugates.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: September 9, 2014
    Assignee: Hanmi Science Co., Ltd
    Inventors: Sung Min Bae, Dae Seong Im, Min Young Kim, Chang Ki Lim, Sung Youb Jung, Se Chang Kwon
  • Method for the mass production of immunoglobulin constant region
    Patent number: 8822650
    Abstract: Disclosed are a recombinant expression vector comprising a nucleotide sequence encoding an E. coli-derived signal sequence and a nucleotide sequence encoding an immunoglobulin constant region, and a transformant transformed with the expression vector. Also, disclosed is a method of mass-producing an immunoglobulin constant region by culturing the transformant and expressing the immunoglobulin constant region in a water-soluble form.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: September 2, 2014
    Assignee: Hanmi Science Co., Ltd
    Inventors: Sung Youb Jung, Jin Sun Kim, Young Jin Park, Ki-Doo Choi, Se Chang Kwon, Gwan Sun Lee
  • COMMON MODE FILTER AND METHOD OF MANUFACTURING THE SAME
    Publication number: 20140240075
    Abstract: Disclosed herein is a common mode filter, including: a magnetic substrate; and a body part formed on the magnetic substrate, wherein the body part is configured of an insulating layer surrounding a coil electrode, an outer electrode terminal connected with an end of the coil electrode, and a magnetic resin composite, the insulating layer is formed on the magnetic substrate, having a margin part M disposed at an edge of the magnetic substrate, and the magnetic resin composite is filled in an empty space of the body part including the margin part M, thereby promoting a consecutive flow of magnetic flux that is generated from the coil electrode.
    Type: Application
    Filed: February 27, 2014
    Publication date: August 28, 2014
    Applicant: Samsung Electro-Mechanics Co., Ltd.
    Inventors: Jin Hyuck YANG, Young Seuck YOO, Sung Kwon WI, Hye Won BANG, Geon Se CHANG, Young Do KWEON, Ju Hwan YANG
  • PHARMACEUTICAL COMPOSITION FOR TREATING CANCER, COMPRISING INTERFERON ALPHA CONJUGATE
    Publication number: 20140219961
    Abstract: A method for preventing or treating a cancer includes administering an anti-cancer pharmaceutical composition including an interferon alpha or a polymer conjugate thereof. The pharmaceutical composition can be co-administered with anti-cancer agents. The interferon alpha conjugate shows a longer in vivo half-life and a more excellent anti-cancer activity than the conventional interferon alpha, and in particular, its co-administration with an anti-cancer agent such as gemcitabine has synergistic inhibitory effects on cancer cell growth and proliferation so as to exhibit a remarkably excellent anti-cancer activity. Further, the anti-cancer pharmaceutical composition has excellent in vivo half-life and anti-cancer activity to greatly reduce administration frequency.
    Type: Application
    Filed: September 5, 2012
    Publication date: August 7, 2014
    Applicants: BEIJING HANMI PHARMACEUTICAL CO., LTD., HANMI SCIENCE CO., LTD.
    Inventors: Sung Youb Jung, Young Eun Woo, Se Young Lim, In Young Choi, Jae Ho Lee, Se Chang Kwon, Sung Hwan Moon, Jiawang Liu
  • CONJUGATE COMPRISING OXYNTOMODULIN AND AN IMMUNOGLOBULIN FRAGMENT, AND USE THEREOF
    Publication number: 20140212440
    Abstract: The present invention relates to a conjugate comprising oxyntomodulin, an immunoglobulin Fc region, and non-peptidyl polymer wherein the conjugate being obtainable by covalently linking oxyntomodulin to immunoglobulin Fc region via non-peptidyl polymer, and a pharmaceutical composition for the prevention or treatment of obesity comprising the conjugates. The conjugate comprising oxyntomodulin and the immunoglobulin Fc of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis without side-effects, unlike native oxyntomodulin, and also shows excellent receptor-activating effects and long-term sustainability, compared to native oxyntomodulin. Thus, it can be widely used in the treatment of obesity with safety and efficacy.
    Type: Application
    Filed: June 15, 2012
    Publication date: July 31, 2014
    Applicant: HANMI SCIENCE CO., LTD
    Inventors: Sung Youb Jung, Dae Jin Kim, Sung Hee Park, Young Eun Woo, In Young Choi, Se Chang Kwon
  • COMMON MODE FILTER AND METHOD OF MANUFACTURING THE SAME
    Publication number: 20140176283
    Abstract: Disclosed herein are a common mode filter for increasing inductance using simpler structure and a method of manufacturing the same, the common mode filter including: a magnetic material substrate; an insulating layer included on an upper portion of the magnetic material substrate and having a coil electrode formed therein; an opening part penetrating through a central portion of the insulating layer; and a magnetic composite formed in the opening part, wherein the opening part has a side wall inclined at a predetermined angle.
    Type: Application
    Filed: December 23, 2013
    Publication date: June 26, 2014
    Applicant: SAMSUNG ELECTRO-MECHANICS CO., LTD.
    Inventors: Ju Hwan YANG, Sung Kwon WI, Jang Su KIM, Geon Se CHANG, Young Do KWEON
  • COMMON MODE FILTER HAVING SIGNAL COMPENSATION FUNCTION
    Publication number: 20140176277
    Abstract: Disclosed herein is a common mode filter having a signal compensating function, including: a magnetic substance substrate included as a base of the common mode filter; a first conductor coil portion that is formed on a surface of the magnetic substance substrate and is included to remove common mode noise generated in a circuit; and a second conductor coil portion that is electrically connected to the first conductor coil portion to be formed on an upper portion of the first conductor coil portion, and is included to compensate for a signal reduction portion of the circuit due to removal of noise by using the first conductor coil portion.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 26, 2014
    Applicant: Samsung Electro-Mechanics Co., Ltd.
    Inventors: Geon Se CHANG, Sung Kwon Wi
  • COMMON MODE FILTER
    Publication number: 20140176279
    Abstract: Disclosed herein is a common mode filter including: a coil part including a conductor coil provided in an insulating part; a plurality of external electrodes provided on the insulating part while being electrically connected to the conductor coil; and a magnetic material part provided in a region between the plurality of external electrodes on the insulating part. By this configuration, impedance characteristics of the common mode filter may be improved.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 26, 2014
    Applicant: SAMSUNG ELECTRO-MECHANICS CO., LTD.
    Inventors: Ju Hwan YANG, Geon Se CHANG, Young Do KWEON, Sung Kwon WI