Abstract: The present invention relates to a composition for preventing or treating diseases caused by mitochondrial dysfunction, containing, as an active ingredient, an isoquinoline derivative compound represented by chemical formula 1, or a pharmaceutically acceptable salt thereof, and does not induce mitochondrial damage, unlike conventional mitochondrial toxins such as CCCP, and specifically and excellently promotes the activity of mitophagy to alleviate mitochondrial disfunction, and thus can be effectively used in the treatment of diseases caused by mitochondrial dysfunction.

Abstract: Disclosed herein is a refrigerator capable of improving a user's convenience by locating a knob for adjusting a temperature of a cooling container above the cooling container. The refrigerator includes: a first storage room; a second storage room positioned below the first storage room; a cooling container positioned in the inside of the first storage room, and forming a cooling space maintained at a temperature that is different from a temperature of the first storage room; and a knob configured to adjust a temperature of the cooling space and positioned above the cooling container.

Abstract: Disclosed herein is a refrigerator capable of improving a user's convenience by locating a knob for adjusting a temperature of a cooling container above the cooling container. The refrigerator includes: a first storage room; a second storage room positioned below the first storage room; a cooling container positioned in the inside of the first storage room, and forming a cooling space maintained at a temperature that is different from a temperature of the first storage room; and a knob configured to adjust a temperature of the cooling space and positioned above the cooling container.