Abstract: The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

Abstract: The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

Abstract: The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

Abstract: The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

Abstract: The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

Abstract: The present invention relates to a method for synthesizing ramalin, and more particularly to a method for synthesizing ramalin, which comprises allowing 2-hydrazinylphenol to react with L-glutamic acid having a protected carboxyl group at C-1 and a protected amino group at C-2, and a method for preventing decomposition of the ramalin. According to the present invention, ramalin having excellent antioxidant and anti-inflammatory activities can be synthesized in high yield, and thus can be produced in large amounts. In addition, ramalin can be stably maintained for a long period of time, and thus can be easily used for industrial purposes.

Abstract: The present invention relates to the novel use (anti-inflammatory activity) of Ramalin isolated from the Antarctic lichen Ramalina terebrata, and more specifically to a pharmaceutical composition containing Ramalin as an active ingredient. Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. In addition, it inhibits the activation of the inflammatory mediator NF-?B, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. Thus, the composition containing Ramalin can be effectively used to fundamentally treat or prevent inflammatory diseases or immune diseases and to relieve or alleviate the symptoms of the diseases.

Abstract: Disclosed is a method of pretreating lignocellulose-based biomass by extracting lignin from biomass by adding a solvent for dissolving lignin to the lignocellulose-based biomass including lignin, hemicellulose and cellulose, and extracting the cellulose and/or hemicellulose by adding an ionic liquid to the remaining biomass after extracting the lignin.

Abstract: A lithium secondary battery having a winding-type electrode assembly and a case accommodating the electrode assembly, and a method of manufacturing thereof. In the lithium secondary battery, ion-conductive polymer is contained in at least one of a hollow portion of the electrode assembly and an inner space of the case other than the hollow portion. The hollow portion and/or the inner space of the case of the electrode assembly is filled with ion-conductive polymer which can consume the heat generated in the battery and which is changed into a gel-state by an electrolytic solution, to dissipate the heat generated in the battery. Accordingly, the explosion of the battery can be suppressed, thereby preventing the reliability and safety of the battery from lowering.

Abstract: A lithium secondary battery has an electrode assembly including a positive electrode plate having a positive electrode current collector and a positive electrode sheet fixed to at least one surface of the positive electrode current collector and having a positive electrode active material as a main component, a negative electrode plate having a negative electrode current collector and a negative electrode sheet fixed to at least one surface of the negative electrode current collector and having a negative electrode active material as a main component, and a separator interposed between the positive electrode plate and the negative electrode plate. A current controller for cutting off current at a minimum temperature is present on each of the positive and negative electrode plates.

Abstract: An organic electrolytic solution and a lithium secondary battery employing the same are provided. The organic electrolytic solution contains an organic solvent and a lithium salt and the organic solvent includes 20 to 60% by volume of ethylene carbonate, 20 to 70% by volume of dialkyl carbonate and 5 to 30% by volume of a fluorinated toluene compound. The organic electrolytic solution has improved high-temperature exposure characteristic by virtue of the use of a fluorinated toluene compound having a high boiling point in combination with mixed solvents of ethylene carbonate and dialkyl carbonate. The lithium secondary battery employing the organic electrolytic solution is excellent in the high-temperature exposure characteristic, while maintaining good discharge capacity and lifetime characteristics.

Abstract: A lithium secondary battery and a method of manufacturing the battery. In the lithium secondary battery including a positive electrode plate having a positive electrode current collector and a positive electrode sheet having a positive electrode active material fixed to at least one surface of the positive electrode current collector, a negative electrode plate having a negative electrode current collector and a negative electrode sheet having a negative electrode active material fixed to at least one surface of the negative electrode current collector, a separator is interposed between the positive electrode plate and the negative electrode plate, and a coating of a polymer material having a high elongation ratio is present on at least each one outer surface of the positive and negative electrode plates to improve battery safety.

Abstract: A cylindrical secondary battery includes a case, a cathode plate and an anode plate installed in the case, and a separator interposed therebetween, a cap on the case and a cap cover coupled to the cap and having a vent hole, and a one-way valve installed in the vent hole. The one-way valve includes a hollow body portion inserted in the vent hole of the cap cover, gas passing grooves at the outer circumferential surface of the hollow body, an upper flange at the outer circumferential surface of the hollow body, disposed above the cap cover, a lower flange at the outer circumferential surface of the hollow body, disposed under the cap cover, a spring elastically supported between the upper flange and the cap cover, and a fragile portion closing an upper portion of the hollow body.

Abstract: An organic electrolytic solution and a lithium secondary battery employing the same are provided. The organic electrolytic solution contains an organic solvent and a lithium salt and the organic solvent includes 20 to 60% by volume of ethylene carbonate, 20 to 70% by volume of dialkyl carbonate and 5 to 30% by volume of a fluorinated toluene compound. The organic electrolytic solution has improved high-temperature exposure characteristic by adding a fluorinated toluene compound having a high boiling point to mixed solvents of ethylene carbonate and dialkyl carbonate. The lithium secondary battery employing the organic electrolytic solution is excellent in the high-temperature exposure characteristic, while maintaining good discharge capacity and lifetime characteristics.

Abstract: A lithium secondary battery having a winding-type electrode assembly and a case accommodating the electrode assembly, and a method of manufacturing thereof. In the lithium secondary battery, ion-conductive polymer is contained in at least one of a hollow portion of the electrode assembly and an inner space of the case other than the hollow portion. The hollow portion and/or the inner space of the case of the electrode assembly is filled with ion-conductive polymer which can consume the heat generated in the battery and which is changed into a gel-state by an electrolytic solution, to dissipate the heat generated in the battery. Accordingly, the explosion of the battery can be suppressed, thereby preventing the reliability and safety of the battery from lowering.