Abstract: The present invention relates to an intracellular expression enhancing genetic element, which enhances the intracellular expression of target protein encoded in RNA therapeutics such as mRNA vaccines and RNA medicines. In more detail, the present invention relates to the RNA molecule which has the genetic element capable of enhancing the intracellular expression of target protein encoded in RNA therapeutics delivered into cells; the plasmid used to synthesize the RNA molecule having the genetic element “E3”; the method for synthesizing RNA molecule having the genetic element “E3” using the plasmid and utilizing the synthesized RNA molecule as RNA therapeutics.

Abstract: The present invention discloses an encoding apparatus using a Discrete Cosine Transform (DCT) scanning, which includes a mode selection means for selecting an optimal mode for intra prediction; an intra prediction means for performing intra prediction onto video inputted based on the mode selected in the mode selection means; a DCT and quantization means for performing DCT and quantization onto residual coefficients of a block outputted from the intra prediction means; and an entropy encoding means for performing entropy encoding onto DCT coefficients acquired from the DCT and quantization by using a scanning mode decided based on pixel similarity of the residual coefficients.

Abstract: The present invention relates to a composition comprising chlorella extract for preventing or treating liver diseases. The composition comprising the chlorella extract according to the present invention may be applied to medical supplies and health supplementary food and the like, and the chlorella extract of the present invention may be usefully used as a composition for preventing or treating liver diseases because it shows inhibitory effect on liver function injury in a liver function injured model.

Abstract: Provided are a system and method for preventing the intrusion of an abnormal GPRS tunneling protocol (GTP) packet. The system includes: a system management unit including a monitoring unit which monitors a state of the system and a mode changing unit which changes an operation mode of the system based on the state of the system; a packet capture unit including a packet management unit which stores information about a GTP packet based on the operation mode of the system and a detection result checking unit which determines whether to drop the GTP packet; and a packet detection unit including a packet parsing unit which parses the information about the GTP packet and a packet analysis unit which analyzes the parsed information about the GTP packet, wherein the operation mode of the system is an intrusion prevention system (IPS) mode or a bypass mode.

Abstract: A porous artificial transplant material to replace autogenous bone with excellent biocompatibility, cytocompatibility and biodegradability is provided. More specifically, a porous scaffold for tissue engineering including chitosan/hydroxyapatite-amylopectin (Chitosan/HAp-AP) and a preparation method thereof are provided. The porous scaffold for tissue engineering has cross linkage among chitosan, hydroxyapatite and amylopectin, which provides advantageous effect including superior cell proliferation and transmission, and excellent thermal stability and mechanical strength. Further, considering excellent biocompatibility and biodegradability which do not harm human body, the porous scaffold can be widely used as an artificial transplant material to replace autogenous bone in biomedical field.

Abstract: The present invention relates to a composition comprising chlorella extract for preventing or treating liver diseases. The composition comprising the chlorella extract according to the present invention may be applied to medical supplies and health supplementary food and the like, and the chlorella extract of the present invention may be usefully used as a composition for preventing or treating liver diseases because it shows inhibitory effect on liver function injury in a liver function injured model.

Abstract: There is provided a new use of a hydroxydihydrobovolide compound having effects on preventing hair loss and growing hairs. Since the hydroxydihydrobovolide compound has effects on increasing survival rates of human hair follicle dermal papilla cells and hair outer root sheath cells and also growing a length of hairs, the compound is of great value as a pharmaceutical composition or cosmetic composition for improving scalp or preventing hair loss. Further, since the hydroxydihydrobovolide compound is isolated and purified from Eucheuma cottonii that is red algae and does not induce cytotoxicity, it is stable in the body and thus can be used as a raw material for functional health food.

Abstract: Devices and methods use an integrated microfluidic system that has the capability of realizing a wide range of accurate dilutions in a logarithmic way through semi-direct dilution of samples inside a chip. The device for dose response analysis is able to contain a first fluid source on a microfluidic chip, wherein the first fluid source comprises a drug, a second fluid source on the microfluidic chip, a mixing area on the microfluidic chip fluidically coupling with the first and the second fluidic source, and a detection area coupling with the mixing area for drug information detection using a detection system.

Abstract: A programmable fluidic device for generating droplets with resolutions of micrometer in size and milliseconds in generation timing is provided. The programmable fluidic device has a valve forming a droplet cutter, which contains a fluid deflectable membrane capable of controlling the flow of a dispensing fluid from a fluidic dispensing channel. The programmable fluidic device is able to perform temporal control over the droplet generation independent from the size control.

Abstract: A method of alleviating or preventing inflammation in an animal is provided. In concrete, the method comprises the step of administering to an animal a composition including an Ecklonia cava extract in an amount effective to suppress SOCS-3 expression in the animal to thereby alleviate or prevent inflammation in the animal.

Abstract: There is provided a pharmaceutical composition for preventing or treating human immunodeficiency virus, and more particularly, to a pharmaceutical composition and health functional food for preventing or treating/improving human immunodeficiency virus, the pharmaceutical composition and health functional food including a new compound with chitooligosaccharides conjugated amino acids or dipeptides as an effective component. The new compound has an excellent anti-HIV effect through an activity of inhibiting a HIV initial infection by interrupting an interaction between host-virus membranes, and also activities of inhibiting reverse transcriptase and protease of HIV. The compound according to the present invention is a conjugate synthesized through conjugating chitooligosaccharides derived from a natural material with amino acids or dipeptides. The compound is stable without cytotoxicity.

Abstract: There is provided a new use of protein hydrolysates and peptide derived from seahorses for preventing or treating a neurodegenerative disease, and more particularly a composition and health functional foods for preventing or treating a neurodegenerative disease including seahorse protein hydrolysates or peptide isolated and purified from the same as an effective component.

Abstract: An IP spoofing detection apparatus is provided. The IP spoofing detection apparatus comprising, a tunnel information extracting unit which extracts a first TEID and a user equipment IP address from a payload of a first GTP packet, and an abnormal packet detecting unit which extracts a second TEID from a header of a second GTP packet, and extracts a source IP address from a payload of the second GTP packet, wherein the abnormal packet detecting unit detects the second GTP packet as an IP spoofing packet if the first TEID and the second TEID are equal to each other, and the user equipment IP address and the source IP address are different from each other.

Abstract: Disclosed is an antihypertensive composition containing as an active ingredient a gelatin extract made from the skins of a skate ray and a peptide isolated from the extract. The present invention is directed to a pharmaceutical composition for a hypertension prevention and therapy containing as an active ingredient a hydrolysate of a gelatin extract isolated from the skins of a skate ray, a method for preparing a hydrolysate of a gelatin extract made from the skins of a skate ray, and the use of a new peptide having an antihypertensive activity isolated and purified from the hydrolysate.

Abstract: Disclosed are a pharmaceutical composition for a sexual function improvement, an erection dysfunction therapy agent containing the urechis unicinctus as an effective component, a health function food for a sexual function improvement and a method for preparing an urechis unicinctus extract with a sexual function improvement activation each of which contains an urechis unicinctus extract which is added as an effective component and yielded by way of a process at a temperature 100˜130° C. at a pressure of 1 Kgf/cm2 for 20˜40 minutes and then with an ultrasonic wave at a frequency 35˜45 KHz for 50˜70 minutes.

Abstract: A novel use of phytosterol isolated from Navicula incerta having effect of preventing or treating liver cancer is provided. Accordingly, a composition for preventing or treating liver cancer including stigmasterol and 5?-hydroxysitostanol isolated from Navicula incerta as an active ingredient is provided. Accordingly, and 5?-hydroxysitostano upregulate expression of genes involved with hepatoma cell apoptosis inducing factors, while downregulating genes involved with hepatoma cell apoptosis inhibiting genes, thereby lead into effective prevention or treatment of liver cancer.

Abstract: A novel use of chrysophanol for skin whitening is provided, in which chrysophanol is included in a cosmetic composition as an effective ingredient for skin whitening. The chrysophanol compound has excellent stability and can also effectively inhibit melanin production via mechanism of inhibiting expression and activity of tyrosinase.

Abstract: The effects on human hair growth of 7?-phloroeckol (1-(3?,5?-dihydroxyphenoxy)-7-(2?,4?,6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin) isolated from E. cava (Ecklonia cava) have been studied in cell systems. The cell-proliferation and anti-apoptotic effects on human human hair follicle dermal papilla cells (HFDPC) and human keratinocytes (human epidermal keratinocytes: HaCaT) were investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and western blot. The 7?-phloroeckol significantly increased HFDPC and HaCaT proliferation. With HFDPC and HaCaT, the amount of PI3K and phosphorylated AKT protein expression increased in a way which was dependent on the extent of 7?-phloroeckol treatment. Also, the levels of MEK½, phosphorylated ERK and c-Fos proteins, which are associated with cell proliferation, increased in a way which was dependent on the extent of 7?-phloroeckol treatment.

Abstract: The present invention relates to a composition for preventing skin aging containing chitooligosaccharides as an active ingredient. The invention provides a cosmetic composition for preventing skin aging caused by UV rays containing chitooligosaccharides of 1-3 kDa, 3-5 kDa or 5-10 kDa molecular weight as an active ingredient.

Abstract: The present invention relates to a HIV-1 inhibiting pharmaceutical composition containing, as an active ingredient, 6,6?-bieckol which is a phloroglucinol polymer compound separated from Ecklonia cava. The Ecklonia cava-derived 6,6?-bieckol according to the present invention inhibits HIV-1 induced cell fusion, the cell lysis effect, and the cytopathogenic effect including virus p24 antibody production, exhibits RT enzyme inhibition activity and HIV-1 infection inhibition activity, and shows no cytotoxicity at the concentration that almost perfectly inhibits HIC-1 replication.