Abstract: A pulsed field delivery device for delivery of electroporation treatment to cancerous and pre-cancerous regions of the gastrointestinal tract is described. It has a first expanding body coupled non-conductively to a second expanding body wherein the non-conductive coupling allows elements of the expanding bodies to sit on opposite sides of a tissue across which pulsed electric fields are applied. An elongate shaft has a proximal end which extends exterior of the patient so that a user can advance and withdraw the device when required. The device also comprises an elongate member or sheath which can be advanced over or retracted back off of the distal end of the device providing protection during device movement. The electrodes are arranged to radially expand and to move closer together to pinch diseased tissue being treated.

Abstract: An electroporation apparatus has electroporation probe terminals for linking with electrodes. A foam is injected at the treatment site to displace blood rather than mixing with it, increasing the contact time of a higher concentration of active agent with the tissue and thus resulting in greater efficacy. With foam solutions, a lower concentration of agent can be used to obtain the same therapeutic effect as in their liquid counterpart, reducing the prevalence of side effects associated with higher concentrations. A foam solution compared to an equivalent liquid solution enables more efficient cell electroporation particularly where bipolar pulses have been employed by mitigating an increase in tissue conductivity as would normally be observed with a comparable liquid solution. A more efficient cell permeabilisation would result in better results where electroporation is being delivered alone or as a tool to aid in the uptake of molecules into the cell.

Abstract: An electroporation apparatus has an electroporation probe terminals for linking with electrodes. A foam is injected at the treatment site to displace blood rather than mixing with it, increasing the contact time of a higher concentration of active agent with the tissue and thus resulting in greater efficacy. With foam solutions, a lower concentration of agent can be used to obtain the same therapeutic effect as in their liquid counterpart, reducing the prevalence of side effects associated with higher concentrations. A foam solution compared to an equivalent liquid solution enables more efficient cell electroporation particularly where bipolar pulses have been employed by mitigating an increase in tissue conductivity as would normally be observed with a comparable liquid solution. A more efficient cell permeabilisation would result in better results where electroporation is being delivered alone or as a tool to aid in the uptake of molecules into the cell.

Abstract: An electroporation apparatus has an electroporation probe terminals for linking with electrodes. A foam is injected at the treatment site to displace blood rather than mixing with it, increasing the contact time of a higher concentration of active agent with the tissue and thus resulting in greater efficacy. With foam solutions, a lower concentration of agent can be used to obtain the same therapeutic effect as in their liquid counterpart, reducing the prevalence of side effects associated with higher concentrations. A foam solution compared to an equivalent liquid solution enables more efficient cell electroporation particularly where bipolar pulses have been employed by mitigating an increase in tissue conductivity as would normally be observed with a comparable liquid solution. A more efficient cell permeabilisation would result in better results where electroporation is being delivered alone or as a tool to aid in the uptake of molecules into the cell.

Abstract: An electroporation apparatus has an electroporation probe terminals for linking with electrodes. A foam is injected at the treatment site to displace blood rather than mixing with it, increasing the contact time of a higher concentration of active agent with the tissue and thus resulting in greater efficacy. With foam solutions, a lower concentration of agent can be used to obtain the same therapeutic effect as in their liquid counterpart, reducing the prevalence of side effects associated with higher concentrations. A foam solution compared to an equivalent liquid solution enables more efficient cell electroporation particularly where bipolar pulses have been employed by mitigating an increase in tissue conductivity as would normally be observed with a comparable liquid solution. A more efficient cell permeabilization would result in better results where electroporation is being delivered alone or as a tool to aid in the uptake of molecules into the cell.

Abstract: An electroporation apparatus has an electroporation probe terminals for linking with electrodes. A foam is injected at the treatment site to displace blood rather than mixing with it, increasing the contact time of a higher concentration of active agent with the tissue and thus resulting in greater efficacy. With foam solutions, a lower concentration of agent can be used to obtain the same therapeutic effect as in their liquid counterpart, reducing the prevalence of side effects associated with higher concentrations. A foam solution compared to an equivalent liquid solution enables more efficient cell electroporation particularly where bipolar pulses have been employed by mitigating an increase in tissue conductivity as would normally be observed with a comparable liquid solution. A more efficient cell permeabilization would result in better results where electroporation is being delivered alone or as a tool to aid in the uptake of molecules into the cell.

Abstract: A monitoring method is performed by a digital processor while a subject is asleep or with little movement. The method includes receiving transducer signals for a subject and training a model for characteristics of a subject or subject group. The model is used in generating sleep data according to real-time correspondence and values of transducer signals including subject rib displacement, subject abdomen displacement, subject torso movement, and subject orientation. Combinations of the transducer inputs are used to determine features from which outputs such as an AHI score are determined. A feature matrix is normalized based on dynamically-generated positional epochs bordered by subject movements to new positions and used to provide a normalization matrix.

Abstract: A monitoring method is performed by a digital processor while a subject is asleep or with little movement. The method includes receiving transducer signals for a subject and training a model for characteristics of a subject or subject group. The model is used in generating sleep data according to real-time correspondence and values of transducer signals including subject rib displacement, subject abdomen displacement, subject torso movement, and subject orientation. Combinations of the transducer inputs are used to determine features from which outputs such as an AHI score are determined. A feature matrix is normalized based on dynamically-generated positional epochs bordered by subject movements to new positions and used to provide a normalization matrix.