Abstract: The present invention promotes the activation of various physiological functions according to the stimulation of the body by superimposing a reference wave microcurrent of a low frequency and a main wave microcurrent of a high frequency into a preset pattern, or by additionally superimposing a multiple superimposed wave microcurrent discretely having a frequency of a larger magnitude sequentially than the main wave microcurrent and applying it to living organisms, and enables that the use and expandability can be increased by providing an additional configuration in which a multifunctional portable housing that can select AC electric stimulation and DC electric stimulation is worn on the wrist of the human body, thereby enabling the application of an electrical stimulation tailored to the body or disease/health condition of a user.

Abstract: The present invention relates to a composition for preventing or treating transplantation rejection or a transplantation rejection disease, comprising a novel compound and a calcineurin inhibitor. A co-administration of the present invention 1) reduces the activity of pathogenic Th1 cells or Th17 cells, 2) increases the activity of Treg cells, 3) has an inhibitory effect against side effects, such as tissue damage, occurring in the sole administration thereof, 4) inhibits various pathogenic pathways, 5) inhibits the cell death of inflammatory cells, and 6) increases the activity of mitochondria, in an in vivo or in vitro allogenic model, a transplantation rejection disease model, a skin transplantation model, and a liver-transplanted patient, and thus inhibits transplantation rejection along with mitigating side effects possibly occurring in the administration of a conventional immunosuppressant alone.

Abstract: The present invention promotes the activation of various physiological functions according to the stimulation of the body by superimposing a reference wave microcurrent of a low frequency and a main wave microcurrent of a high frequency into a preset pattern, or by additionally superimposing a multiple superimposed wave microcurrent discretely having a frequency of a larger magnitude sequentially than the main wave microcurrent and applying it to living organisms, and enables that the use and expandability can be increased by providing an additional configuration in which a multifunctional portable housing that can select AC electric stimulation and DC electric stimulation is worn on the wrist of the human body, thereby enabling the application of an electrical stimulation tailored to the body or disease/health condition of a user.