Abstract: A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at least 12 hours, preferably 24 hours or more and the use of the composition to treat various neurological diseases.

Abstract: According to an embodiment thereof, the method comprises using a pair of reaction vessels, sequentially, to treat the sludge. Both vessels are pressurized, and the first thereof has an aerator for aerating the sludge, and receives sulfuric acid and chlorine thereinto through a port. A dewatering device is provided upstream of the first vessel, and the outlet of the first vessel is coupled to an inlet of the second vessel through another dewatering device. The second vessel defines a final-treatment chamber in which the sludge is exposed to ozone, air and lime. The treatment method, then, comprises the steps namely: introducing the sludge into the first vessel and oxidizing and depressing the pH of the sludge so introduced, and recycling the sludge in the first vessel over a given period of time. Thereafter the sludge is dewatered and conducted to the second vessel wherein it is exposed to air, ozone and lime, as aforesaid, and discharged after a like period of time.

Abstract: According to an embodiment thereof, the apparatus comprises a pair of reaction vessels in which, sequentially, to treat the sludge. Both vessels are pressurized, and the first thereof has an aerator for aerating the sludge, and receives sulfuric acid and chlorine thereinto through a port. A dewatering device is provided upstream of the first vessel, and the outlet of the first vessel is coupled to an inlet of the second vessel through another dewatering device. The second vessel defines a final-treatment chamber in which the sludge is exposed to ozone, air and lime. The treatment method, then, comprises the steps carried out in the apparatus, namely: introducing the sludge into the first vessel and oxidizing and depressing the pH of the sludge so introduced, and recycling the sludge in the first vessel over a given period of time. Thereafter the sludge is dewatered and conducted to the second vessel wherein it is exposed to air, ozone and lime, as aforesaid, and discharged after a like period of time.