Patents by Inventor Sean A. Evans

Sean A. Evans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140242182
    Abstract: In one aspect, the disclosure provides formulations that stabilize proteins, wherein the formulations comprise a buffer. In some embodiments, the buffer comprises potassium mono-hydrogen-phosphate and potassium di-hydrogen-phosphate, or the buffer comprises sodium mono-hydrogen-phosphate and sodium di-hydrogen-phosphate. In some embodiments, the protein is a therapeutic protein. In some embodiments, the therapeutic protein is antithrombin.
    Type: Application
    Filed: July 6, 2012
    Publication date: August 28, 2014
    Applicant: rEVO Biologics, Inc
    Inventors: Sean A. Evans, Greg J. Allard, Nicholas C. Masiello
  • Patent number: 4911908
    Abstract: An interferon preparation to be administered topically is provided comprising: (a) a therapeutically effective amount of one or more interferons; (b) a vehicle base compatible with the interferon or interferons being administered; (c) an effective amount of one or more protease inhibitors for the purpose of reducing the rate of decay of the biological activity of the interferon or interferons due to proteolytic agents; and (d) an effective amount of one or more anti-microbial agents. In certain preferred embodiments of the invention, the vehicle base is prepared from a mixture of polyethylene glycols or includes hydroxyethyl cellulose as a thickening agent.
    Type: Grant
    Filed: March 12, 1987
    Date of Patent: March 27, 1990
    Assignee: Interferon Sciences, Inc.
    Inventors: Leonard F. Estis, Sean A. Evans, Douglas Testa
  • Patent number: 4710376
    Abstract: A substantially non-toxic, stable, topical therapeutic composition is provided which comprises:(a) a therapeutically active component which is susceptible to oxidative degradation;(b) an oxidative degradation-inhibitory amount of a redox system containing(1) a water soluble polymer containing a plurality of reducing moieties covalently bound thereto and(2) a water soluble polymer containing a plurality of oxidizing moieties covalently bound thereto; and(c) an aqueous vehicle base compatible with the therapeutically active component.
    Type: Grant
    Filed: February 1, 1985
    Date of Patent: December 1, 1987
    Assignee: Interferon Sciences, Inc.
    Inventors: Sean A. Evans, Eva A. Terpinski, Douglas Testa
  • Patent number: 4680175
    Abstract: An interferon preparation to be administered topically is provided comprising: (a) a therapeutically effective amount of one or more interferons; (b) a vehicle base compatible with the interferon or interferons being administered; (c) an effective amount of one or more protease inhibitors for the purpose of reducing the rate of decay of the biological activity of the interferon or interferons due to proteolytic agents; and (d) an effective amount of one or more anti-microbial agents. In certain preferred embodiments of the invention, the vehicle base is prepared from a mixture of polyethylene glycols or includes hydroxyethyl cellulose as a thickening agent.
    Type: Grant
    Filed: February 7, 1984
    Date of Patent: July 14, 1987
    Assignee: Interferon Sciences, Inc.
    Inventors: Leonard F. Estis, Sean A. Evans, Douglas Testa